<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">OJS</journal-id><journal-title-group><journal-title>Open Journal of Statistics</journal-title></journal-title-group><issn pub-type="epub">2161-718X</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/ojs.2014.410076</article-id><article-id pub-id-type="publisher-id">OJS-51467</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Physics&amp;Mathematics</subject></subj-group></article-categories><title-group><article-title>
 
 
  Cusp Catastrophe Polynomial Model: Power and Sample Size Estimation
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>ing-Geng</surname><given-names>Chen</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Xinguang</surname><given-names>Chen</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Feng</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Wan</surname><given-names>Tang</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Yuhlong</surname><given-names>Lio</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Yuanyuan</surname><given-names>Guo</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib></contrib-group><aff id="aff5"><addr-line>School of Public Health, Wuhan University, Wuhan, China</addr-line></aff><aff id="aff1"><addr-line>Center of Research, School of Nursing, University of Rochester Medical Center, Rochester, NY, USA</addr-line></aff><aff id="aff3"><addr-line>Institute of Data Sciences, University of Rochester, Rochester, NY, USA</addr-line></aff><aff id="aff6"><addr-line>AD-CARE, Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA</addr-line></aff><aff id="aff4"><addr-line>Department of Epidemiology, University of Florida, Gainesville, FL, USA</addr-line></aff><aff id="aff2"><addr-line>Department of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>din_chen@urmc.rochester.edu(IC)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>18</day><month>11</month><year>2014</year></pub-date><volume>04</volume><issue>10</issue><fpage>803</fpage><lpage>813</lpage><history><date date-type="received"><day>6</day>	<month>October</month>	<year>2014</year></date><date date-type="rev-recd"><day>26</day>	<month>October</month>	<year>2014</year>	</date><date date-type="accepted"><day>8</day>	<month>November</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  Guastello’s polynomial regression method for solving cusp catastrophe model has been widely applied to analyze nonlinear behavior outcomes. However, no statistical power analysis for this modeling approach has been reported probably due to the complex nature of the cusp catastrophe model. Since statistical power analysis is essential for research design, we propose a novel method in this paper to fill in the gap. The method is simulation-based and can be used to calculate statistical power and sample size when Guastello’s polynomial regression method is used to do cusp catastrophe modeling analysis. With this novel approach, a power curve is produced first to depict the relationship between statistical power and samples size under different model specifications. This power curve is then used to determine sample size required for specified statistical power. We verify the method first through four scenarios generated through Monte Carlo simulations, and followed by an application of the method with real published data in modeling early sexual initiation among young adolescents. Findings of our study suggest that this simulation-based power analysis method can be used to estimate sample size and statistical power for Guastello’s polynomial regression method in cusp catastrophe modeling.
 
</p></abstract><kwd-group><kwd>Cusp Catastrophe Model</kwd><kwd> Polynomial Regression Method</kwd><kwd> Statistical Power Analysis</kwd><kwd> Sample Size Determination</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Popularized in the 1970 ’ s by Thom [<xref ref-type="bibr" rid="scirp.51467-ref1">1</xref>] , Thom and Fowler [<xref ref-type="bibr" rid="scirp.51467-ref2">2</xref>] , Cobb and Ragade [<xref ref-type="bibr" rid="scirp.51467-ref3">3</xref>] , Cobb and Watson [<xref ref-type="bibr" rid="scirp.51467-ref4">4</xref>] , and Cobb and Zack [<xref ref-type="bibr" rid="scirp.51467-ref5">5</xref>] , catastrophe theory was proposed to understand a complicated set of behaviors including both gradual and continuous changes and sudden and discrete or catastrophical changes. Computationally, there are two directions to implement this theoretical catastrophe theory. One direction is operationalized by Guastello [<xref ref-type="bibr" rid="scirp.51467-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref7">7</xref>] with the implementation into a polynomial regression approach and another direction by a stochastic cusp catastrophe model from Cobb and his colleagues [<xref ref-type="bibr" rid="scirp.51467-ref5">5</xref>] with implementation in an R package in [<xref ref-type="bibr" rid="scirp.51467-ref8">8</xref>] . And this paper is to discuss the first direction on polynomial cusp catastrophe regression model due to its relative simplicity and ease for implementation as simple regression approach. This model has been used extensively in research. Typical examples include modeling of accident process [<xref ref-type="bibr" rid="scirp.51467-ref7">7</xref>] , adolescent alcohol use [<xref ref-type="bibr" rid="scirp.51467-ref9">9</xref>] , changes in adolescent substance use [<xref ref-type="bibr" rid="scirp.51467-ref10">10</xref>] , binge drinking among college students [<xref ref-type="bibr" rid="scirp.51467-ref11">11</xref>] , sexual initiation among young adolescents [<xref ref-type="bibr" rid="scirp.51467-ref12">12</xref>] , nursing turnover [<xref ref-type="bibr" rid="scirp.51467-ref13">13</xref>] , and effect of HIV prevention among adolescents [<xref ref-type="bibr" rid="scirp.51467-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref14">14</xref>] .</p><p>Even though this polynomial regression method has been widely applied in behavioral studies to investigate the existence of cusp catastrophe, to the best of our knowledge, no reported research has addressed the determination of sample size and statistical power for this analytical approach. Statistical power analysis is an essential part for researchers to efficiently plan and design a research project as pointed out in [<xref ref-type="bibr" rid="scirp.51467-ref15">15</xref>] - [<xref ref-type="bibr" rid="scirp.51467-ref17">17</xref>] . To assist and enhance application of the polynomial regression method in behavioral research, this paper is aimed to fill this method gap by reporting the Monte-Carlo simulation-based method we develope to conduct power analysis and to determine sample size.</p><p>The structure of the paper is as follows. We start with a brief review of the cusp catastrophe model (Section 2), followed by reporting our development of the novel simulation-based approach to calculate the statistical power (Section 3). This approach is then verified through Monte Carlo simulations and is further illustrated with data derived from published study (Section 4). Conclusions and discussions are given at the end of the paper (Section 5).</p></sec><sec id="s2"><title>2. Cusp Catastrophe Model</title><sec id="s2_1"><title>2.1. Overview</title><p>The cusp catastrophe model is proposed to model system outcomes which can incorporate the linear model with extension to nonlinear model along with discontinuous transitions in equilibrium states as control variables vary. According to the catastrophe systems theory [<xref ref-type="bibr" rid="scirp.51467-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref18">18</xref>] - [<xref ref-type="bibr" rid="scirp.51467-ref20">20</xref>] , the dynamics for a cusp system outcome is expressed by the time derivative of its state variable (often called behavioral variable within the context of catastrophe theory) to the potential function: <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x5.png" xlink:type="simple"/></inline-formula>The first derivative of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x6.png" xlink:type="simple"/></inline-formula> will consist of the equilibrium plane of the cusp catastrophe:</p><disp-formula id="scirp.51467-formula2"><label>(1)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x7.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x8.png" xlink:type="simple"/></inline-formula> is called asymmetry or normal control variable and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x9.png" xlink:type="simple"/></inline-formula> is called bifurcation or splitting control variable. In the model, the two control variables <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x10.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x11.png" xlink:type="simple"/></inline-formula> co-vary to determine the behavior outcome variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x12.png" xlink:type="simple"/></inline-formula>. <xref ref-type="fig" rid="fig1">Figure 1</xref> depicts the equilibrium plane which reflects the response surface of the outcome measure <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x13.png" xlink:type="simple"/></inline-formula> at various combinations of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x14.png" xlink:type="simple"/></inline-formula> and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x15.png" xlink:type="simple"/></inline-formula>. It can be seen from the figure that the dynamic changes in a behavior measure <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x16.png" xlink:type="simple"/></inline-formula> has two stable regions (attractors), the lower area in the front left and the upper areas in the front right. Beyond these two regions, behavior <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x17.png" xlink:type="simple"/></inline-formula> becomes unstable. This characteristic can be further revealed by projecting the unstable region to the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x18.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x19.png" xlink:type="simple"/></inline-formula> control plane as a cusp region. The cusp region is characterized by two lines, line O-Q (the ascending threshold) and line O-R (the descending threshold) of the equilibrium surface. In this region, the outcome measure becomes highly unstable, and sudden change or jumping in behavior status will occur, because a very small change in <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x20.png" xlink:type="simple"/></inline-formula> or <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x20.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x21.png" xlink:type="simple"/></inline-formula> or both will lead <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x20.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x21.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x22.png" xlink:type="simple"/></inline-formula> to cross either the threshold line O-Q or O-R.</p><p>Furthermore, the paths A, B, and C in <xref ref-type="fig" rid="fig1">Figure 1</xref> depict three typical but different pathways of change in the</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> Cusp catastrophe model for outcome measures <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x24.png" xlink:type="simple"/></inline-formula> in the equilibrium plane with asymmetry control variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x25.png" xlink:type="simple"/></inline-formula> and bifurcation control variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x26.png" xlink:type="simple"/></inline-formula>. (Annotated by the authors with the original graph produced by Grasman’s R package “cusp”)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-1240370x23.png"/></fig><p>outcome measure<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula>. Path A shows that in any situations where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula>, there is a smooth relation between outcome measure <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula> and the asymmetry variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula>; path B shows that in any situations where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x31.png" xlink:type="simple"/></inline-formula>, if the asymmetry variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x32.png" xlink:type="simple"/></inline-formula> increases to reach and pass the ascending threshold link O-Q, outcome measure <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x33.png" xlink:type="simple"/></inline-formula> will increase suddenly from the low stable region to the upper stable region of the equilibrium plane; and Path C shows a sudden drop in outcome measure <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x34.png" xlink:type="simple"/></inline-formula> as <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x35.png" xlink:type="simple"/></inline-formula> declines to reach and pass the descending threshold line O-R .</p><p>From the affirmative description, it is clearly that a cusp model differs from a linear model in that: 1) A cusp model allows the forward and backward progression follows different paths in the outcome measure and both processes can be modeled simultaneously (see Paths B and C in <xref ref-type="fig" rid="fig1">Figure 1</xref>) while a linear model only permits one type of relationship; 2) A cusp model covers both a discrete component and a continuous component of a behavior change while a linear model covers on continuous process (Path A). In this case a linear model can be considered as a special case of the cusp model; 3) A cusp model consists of two stable regions and two thresholds for sudden and discrete changes. Therefore, the application of the cusp modeling will advance the linear approach and better assist researchers to describe the behavior data while evidence obtained from such analysis, in turn, can be used to advance theories and models to better explain a behavior.</p></sec><sec id="s2_2"><title>2.2. Guastello’s Cusp Catastrophe Polynomial Regression Model</title><p>To operationalize the cusp catastrophe model for behavior research, Guastello [<xref ref-type="bibr" rid="scirp.51467-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref7">7</xref>] developed the polynomial regression approach to implement the concept of cusp model. Since the first publication of this method, it has been widely used in analyzing real data as we described in the Introduction. In this study, we referred the method as Gastello’s polynomial cusp regression. According to Gustello, this approach is derived by inserting regression <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x36.png" xlink:type="simple"/></inline-formula> coefficients into the Equation (1), with change scores <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x37.png" xlink:type="simple"/></inline-formula> (the differences in the measurement scores of a behavior assessed at time 1 and time 2) as a numerical approximation of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x38.png" xlink:type="simple"/></inline-formula>:</p><disp-formula id="scirp.51467-formula3"><label>(2)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x39.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula> is the intercept and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula> is the normally distributed error term. Two additional term <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x42.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x42.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x43.png" xlink:type="simple"/></inline-formula> are added to capture potential deviations of the data from the equilibrium plane. When conducting modeling analysis, a cusp is indicated ONLY if the estimated <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x42.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x43.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x44.png" xlink:type="simple"/></inline-formula> for the cubic term, plus <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x42.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x43.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x44.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x45.png" xlink:type="simple"/></inline-formula> (for the interaction term) or <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x42.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x43.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x44.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x45.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x46.png" xlink:type="simple"/></inline-formula> (for control variable x) in Equation (2) are statistically significant.</p><p>To demonstrate the efficiency of the polynomial regression approach in describing behavioral changes that are cusp, Guastelly [<xref ref-type="bibr" rid="scirp.51467-ref7">7</xref>] recommended a comparative approach. In this approach, two types, four alternative linear models can be constructed and used in modeling the same variables:</p><p>1) Change scores linear models</p><disp-formula id="scirp.51467-formula4"><label>(3)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x47.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.51467-formula5"><label>(4)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x48.png"  xlink:type="simple"/></disp-formula><p>2) Pre-and post-linear models</p><disp-formula id="scirp.51467-formula6"><label>(5)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x49.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.51467-formula7"><label>(6)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/1-1240370x50.png"  xlink:type="simple"/></disp-formula><p>These alternative linear models add another analytical strategy to strength the polynomial regression method. A better data-model fitting (or a larger<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x51.png" xlink:type="simple"/></inline-formula>) of the cusp model (2) than the alternative linear models (3) through (6) is often used as additional evidence supporting the hypothesis that the dynamics of a study behavior follows the cusp catastrophe. Fitting Guastello’s cusp regression model and the four alternative models can all be conducted with commonly available statistical software, including SAS, SPSS, STATA and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x51.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x52.png" xlink:type="simple"/></inline-formula>. More recent discussions and applications of the cusp catastrophe modeling methods can be found in [<xref ref-type="bibr" rid="scirp.51467-ref21">21</xref>] .</p></sec></sec><sec id="s3"><title>3. Simulation-Based Power Analysis Approach for Guastello’s Cusp Regression</title><sec id="s3_1"><title>3.1. A Brief Introduction to Statistical Power</title><p>In statistics, power is defined as the probability of correctly rejecting the null hypothesis. Stated in common language, power is the fraction of the times that the specified null-hypothesis value will be rejected from statistical tests. Operationally based on this definition, if we specify an alternative hypothesis<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula>, a desired type-I error rate<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula>, and a desired power<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula>, then we can calculate the required sample size<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x56.png" xlink:type="simple"/></inline-formula>. Alternatively, we can calculate the statistical power <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x56.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x57.png" xlink:type="simple"/></inline-formula> as a function of sample size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x56.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x57.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x58.png" xlink:type="simple"/></inline-formula> under a specified alternative hypothesis <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x56.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x57.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x58.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x59.png" xlink:type="simple"/></inline-formula> and a desired type-I error rate<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x54.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x56.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x57.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x58.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x60.png" xlink:type="simple"/></inline-formula>. There are extensive literatures on sample size calculation as well as statistical power analysis, see the seminal books from [<xref ref-type="bibr" rid="scirp.51467-ref15">15</xref>] - [<xref ref-type="bibr" rid="scirp.51467-ref17">17</xref>] for power analysis for behavioral sciences.</p><p>As detailed in Chapter 7 in [<xref ref-type="bibr" rid="scirp.51467-ref17">17</xref>] , five factors related to research design interplay with each other to determine the statistical power and sample size for a simple t-test: 1) the rate of type-I error<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula>; 2) the desired statistical power<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula>, 3) the expected treatment effect size of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula>, 4) the standard error <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula> for the expected effect size, and 5) the sample size<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula>. The mathematical formula can then be derived as<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula>. Therefore, to determine the required sample size<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x67.png" xlink:type="simple"/></inline-formula>, we would need to provide data for four of the five design characteristics. Typically, the type-I error <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x67.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x68.png" xlink:type="simple"/></inline-formula> is set at 0.05 and the desired power <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x67.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x69.png" xlink:type="simple"/></inline-formula> is chosen to be 0.85 (or 0.80). The other two will be treatment effect size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x67.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x70.png" xlink:type="simple"/></inline-formula> and its standard error<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x67.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x70.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x71.png" xlink:type="simple"/></inline-formula>. Depending on actual research questions, different values are often selected for these two characteristics.</p><p>Extending the same concept described above for Guastello’s polynomial cusp regression, we would need to specify the corresponding parameter effect size for all <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula> in Equation (2), the standard deviation of the error term<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x73.png" xlink:type="simple"/></inline-formula>. In addition, we need to specify the distribution of the two control variables, the asymmetry <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x73.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x74.png" xlink:type="simple"/></inline-formula> and the bifurcation<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x73.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x75.png" xlink:type="simple"/></inline-formula>; and the distribution of the outcome variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x73.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x76.png" xlink:type="simple"/></inline-formula> at time 1 (i.e.<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x72.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x73.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x76.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x77.png" xlink:type="simple"/></inline-formula>). With these parameters and variables being specified, the required sample size for a significant Cuastello’s cusp regression model can be determined and statistical power can be analyzed.</p></sec><sec id="s3_2"><title>3.2. Simulation-Based Approach for Power Analysis and Sample Size Determination</title><p>Power analysis and sample size determination can be developed for specific purpose. Typically, it is developed to detect treatment effect as in clinical trials or to detect the effect of specific risk factor as in regression. Similar development can be done to Guastello’s cusp regression model for specific repressor in asymmetry variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x78.png" xlink:type="simple"/></inline-formula> or the bifurcation variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x78.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x79.png" xlink:type="simple"/></inline-formula> if they are linked to multiple regressors or even to the overall goodness- of-fit index of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x78.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x79.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x80.png" xlink:type="simple"/></inline-formula>. However, we aim to tackle a more complicated problem to determine whether we can detect a significant overall cusp model. The complexity of cusp catastrophe model makes it rather challenging, if not impossible to derive an analytical formula to determine the statistical power for Guastello’s cusp regression. To deal with this difficult, we propose a Monte-Carlo simulation-based approach. In this method the statistical power is calculated as the fraction of the times that the specified null-hypothesis of “no cusp” is rejected at the given level of type I error. Stated in another way, if there is a cusp, the statistical power will be, among 100 simulations, how many times can we detect the cusp given the sample size and type I error? The detailed steps of the simulation-based approach are outlined as follows:</p><p>1) Simulate data with sample size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula> (i.e. the number of observations for Guastello’s cusp regression modeling) for the asymmetry variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula>, bifurcation variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x83.png" xlink:type="simple"/></inline-formula> and outcome variable at time 1 (i.e.<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x84.png" xlink:type="simple"/></inline-formula>). Data are generated under required specifications for desired study, such as normal distribution with specific means and standard deviations. Guastello’s cusp regression requires that all variables be standardized before data analysis and modeling. In this case, the standard normal distribution can be used to generate data for<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x84.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x85.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x84.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x85.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x86.png" xlink:type="simple"/></inline-formula>and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x84.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x85.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x87.png" xlink:type="simple"/></inline-formula>;</p><p>2) Specify model parameter effect size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x88.png" xlink:type="simple"/></inline-formula> and the standard deviation <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x89.png" xlink:type="simple"/></inline-formula> of the error term of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x89.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x90.png" xlink:type="simple"/></inline-formula> (Equation (2)) obtained from prior knowledge;</p><p>3) Calculate <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x91.png" xlink:type="simple"/></inline-formula> using the data obtained in the previous two Steps. Also generate<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x91.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x92.png" xlink:type="simple"/></inline-formula>;</p><p>4) Fit the Guastello’s cusp regression model (Equation (2)) with least squares method using the data generated for<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula>, and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula>. After model fitting, a significant test is conducted to determine whether the data fit Guastello’s cusp regression model satisfactorily according to the decision rules proposed by Guastello (1982): 1) the estimated <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula> for the cubic term and 2) <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x98.png" xlink:type="simple"/></inline-formula>(for the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x99.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x99.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x100.png" xlink:type="simple"/></inline-formula> interaction term) or <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x99.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x100.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x101.png" xlink:type="simple"/></inline-formula> (for control variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x93.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x94.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x95.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x96.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x97.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x99.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x100.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x101.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x102.png" xlink:type="simple"/></inline-formula>) must be are statistically significant;</p><p>5) Repeat Steps 1 to 4 a large number of times (typically 1000) and calculate the proportion of simulations which satisfy the Guastello’s decision rules. This proportion then provides an estimate of the statistical power for the pre-specified sample size and the study specifications given in Steps 1 and 2;</p><p>6) With the above established five steps for power assessment, sample size is then determined to reach a pre-specified level of statistical power. This is carried out by running Steps 1 to 5 with a range of sample sizes <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x103.png" xlink:type="simple"/></inline-formula> first to obtain the corresponding values of statistical power. Then a statistical power curve is constructed for these ranges of sample sizes. With this power curve, the sample size is determined through back-calculation for a pre-specified power, such as power = 0.85.</p><p>The simulation-based approach described above is implemented in free <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x104.png" xlink:type="simple"/></inline-formula> package and the computer program is available up request from the authors.</p></sec></sec><sec id="s4"><title>4. Simulation Study and Real Example</title><sec id="s4_1"><title>4.1. Monte-Carlo Simulation Analysis</title><sec id="s4_1_1"><title>4.1.1 . Rationale</title><p>To verify the novel approach proposed in Section 3, we simulated four scenarios with <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x105.png" xlink:type="simple"/></inline-formula> observations for each using Guastello’s cusp polynomial regression model (2). The four scenarios represent four cases of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x105.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x106.png" xlink:type="simple"/></inline-formula> with different measurement errors (i.e.<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x105.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x106.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x107.png" xlink:type="simple"/></inline-formula>, 2, 3, and 4). We hypothesized that data with smaller measurement errors will fit the cusp model better than the data with larger errors if the Guastello’s cusp polynomial regression method is used to detect cusp catastrophic changes. Consequently, a larger sample size would be needed to detect a cusp for data with greater measurement errors.</p></sec><sec id="s4_1_2"><title>4.1.2 . Data Generation</title><p>Data are generated with the asymmetry variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula>, bifurcation variable <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula> and outcome variable at time 1 (i.e.<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x110.png" xlink:type="simple"/></inline-formula>) being set as standard normal distribution. The parameter effect size vector is set as <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x111.png" xlink:type="simple"/></inline-formula>. To illustrate the impact of measurement errors on sample sizes, we generate the error term <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x111.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x112.png" xlink:type="simple"/></inline-formula> following the normal distribution as <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x111.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x113.png" xlink:type="simple"/></inline-formula> with increasing measurement error standard deviation of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x108.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x109.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x111.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x114.png" xlink:type="simple"/></inline-formula>, 2, 3, and 4 for each of the four scenarios.</p><p>With the generated<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula>and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula> along with the input values of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula> and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula>is generated using the Guastello’s polynomial regression model. This is achieved by plugging in all values of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x122.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x122.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x123.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x122.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x123.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x124.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x122.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x123.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x124.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x125.png" xlink:type="simple"/></inline-formula>and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x117.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x118.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x119.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x120.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x121.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x122.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x123.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x124.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x125.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x126.png" xlink:type="simple"/></inline-formula> into the following equation:</p><disp-formula id="scirp.51467-formula8"><graphic  xlink:href="http://html.scirp.org/file/1-1240370x127.png"  xlink:type="simple"/></disp-formula><p><xref ref-type="fig" rid="fig2">Figure 2</xref> illustrates one realization of the data generation with <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula> in a pair plot. It can be seen from the figure that the distributions for<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula>and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula> are random (the upper left 3 by 3 plots). Furthermore, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula>is linearly related to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula> as seen from the upper right plot. The second plot on the right-side illustrates the linear relationship between <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x135.png" xlink:type="simple"/></inline-formula> under fixed <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x135.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x136.png" xlink:type="simple"/></inline-formula> and the third plot on the right-side illustrates the cubic relationship between <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x135.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x136.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x137.png" xlink:type="simple"/></inline-formula> and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x135.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x136.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x137.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x138.png" xlink:type="simple"/></inline-formula>. For<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x128.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x129.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x130.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x131.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x132.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x133.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x134.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x135.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x136.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x137.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x138.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x139.png" xlink:type="simple"/></inline-formula>, 3, and 4 (data not shown in figure), the corresponding pair plots would have larger variations.</p></sec><sec id="s4_1_3"><title>4.1.3 . Simulation Analysis</title><p>Four data sets for the four scenarios (e.g., <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula>, 2, 3, and 4) are simulated first. The simulated data are then fitted with Guastello’s cusp regression model using least squares method. The summary statistics of the analyses are given in <xref ref-type="table" rid="table1">Table 1</xref>. It can be seen from the table that for the Scenario where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula>, all the parameters of the polynomial regression model are statistically highly significant <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula> with<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula>, indicating adequate data-cusp model fitting and F-statistic = 60.71 indicating highly significance of the polynomial regression model. The estimated<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x144.png" xlink:type="simple"/></inline-formula>, slightly greater than the true<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x144.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x145.png" xlink:type="simple"/></inline-formula>. Since<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x144.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x145.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x146.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x144.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x145.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x146.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x147.png" xlink:type="simple"/></inline-formula>and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x140.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x141.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x142.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x143.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x144.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x145.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x146.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x147.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x148.png" xlink:type="simple"/></inline-formula> are all highly significant, we conclude that the Guastello’s polynomial regression method is sufficient to detect the specified cusp.</p><p>Results of other three scenarios in <xref ref-type="table" rid="table1">Table 1</xref> indicate that as <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula> increases, the goodness of data-model fitting declines. In the scenario where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula>, the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x151.png" xlink:type="simple"/></inline-formula> drops to 0.454, F-statistic drops to 15.61 (still significant), and the estimated<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x151.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x152.png" xlink:type="simple"/></inline-formula>, close to the true<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x151.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x152.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x153.png" xlink:type="simple"/></inline-formula>. In this case, both <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x151.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x152.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x153.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x154.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x149.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x150.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x151.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x152.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x153.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x154.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x155.png" xlink:type="simple"/></inline-formula> remain significant, indicating</p><fig id="fig2"  position="float"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> Example of simulated data when <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula> where the distributions of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x160.png" xlink:type="simple"/></inline-formula>are standard normal (the upper left 3 by 3 plots) and the relationships between <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x160.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x161.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x160.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x161.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x162.png" xlink:type="simple"/></inline-formula> (as linear), to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x160.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x161.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x162.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x163.png" xlink:type="simple"/></inline-formula> (as linear) and to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x158.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x159.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x160.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x161.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x162.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x163.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x164.png" xlink:type="simple"/></inline-formula> (as cubic)</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-1240370x156.png"/></fig><p>the existence of a cusp. With regard to Scenario 3 where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula>, the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula> further drops to 0.278 and F-statistic to 7.227. The estimated<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula>, again close to its true<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x168.png" xlink:type="simple"/></inline-formula>. In this case, only <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x168.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x169.png" xlink:type="simple"/></inline-formula> is highly significant and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x168.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x169.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x170.png" xlink:type="simple"/></inline-formula> marginally significant, indicating that a cusp is likely. In Scenario 4 where<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x168.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x169.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x170.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x171.png" xlink:type="simple"/></inline-formula>, none of the estimated parameters required to support the cusp is statistically significant. Therefore, we could not be able to determine if the data contain a cusp. A power analysis is needed to assess if the sample size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x165.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x166.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x167.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x168.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x169.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x170.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x171.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x172.png" xlink:type="simple"/></inline-formula> is adequate.</p></sec><sec id="s4_1_4"><title>4.1.4 . Sample Size Estimation</title><p>To demonstrate the proposed novel simulation method, we estimate sample sizes needed for each of the four scenarios to achieve 85% statistical power employing this method and the estimated parameter <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x173.png" xlink:type="simple"/></inline-formula> and the estimated <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x173.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x174.png" xlink:type="simple"/></inline-formula> from <xref ref-type="table" rid="table1">Table 1</xref> in the previous step. <xref ref-type="fig" rid="fig3">Figure 3</xref> summarizes the results. Data in <xref ref-type="fig" rid="fig3">Figure 3</xref> indicate that with 85% statistical power to detect the underlying cusp, the required sample sizes for Scenarios 1 through 4 are 36, 101, 195 and 293, respectively. The required sample size varies proportionately with measurement errors. This result adds more evidence supporting the validity of the simulation-based approach we proposed for power analysis.</p></sec><sec id="s4_1_5"><title>4.1.5 . Reverse-Verification</title><p>If the novel simulation-based approach is valid, the sample size estimates for each of the four scenarios described in previous section will allow approximately 85% chance to detect the underlying cusp. Therefore, we took a reverse approach to compute statistical power by applying the calculated sample size as input for each of the four scenarios. Results in <xref ref-type="fig" rid="fig3">Figure 3</xref> indicated that for Scenario 1, a sample size of 36 observations will be adequate to detect the cusp with 85% statistical power.</p><fig id="fig3"  position="float"><label><xref ref-type="fig" rid="fig3">Figure 3</xref></label><caption><title> Statistical power curves corresponding to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x176.png" xlink:type="simple"/></inline-formula> in plot a), <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x176.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x177.png" xlink:type="simple"/></inline-formula>in plot b), <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x176.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x177.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x178.png" xlink:type="simple"/></inline-formula>in plot c) and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x176.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x177.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x178.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x179.png" xlink:type="simple"/></inline-formula> in plot d). The arrows illustrate the sample size determination from power of 0.85 to calculate the sample size required</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-1240370x175.png"/></fig><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> Parameter estimates, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x180.png" xlink:type="simple"/></inline-formula>, Estimated <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x180.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x181.png" xlink:type="simple"/></inline-formula> and F-Statistic from four simulations with<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x180.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x181.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x182.png" xlink:type="simple"/></inline-formula>, 2, 3 and 4. The rows bolded are corresponding to the cusp determination</title></caption><table><tbody><thead><tr><th align="center" valign="middle" ></th><th align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x183.png" xlink:type="simple"/></inline-formula></th><th align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x184.png" xlink:type="simple"/></inline-formula></th><th align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x185.png" xlink:type="simple"/></inline-formula></th><th align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x186.png" xlink:type="simple"/></inline-formula></th></tr></thead><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x187.png" xlink:type="simple"/></inline-formula>(Intercept)<sub> </sub></td><td align="center" valign="middle" >0.487<sup>***</sup></td><td align="center" valign="middle" >0.473.</td><td align="center" valign="middle" >0.459</td><td align="center" valign="middle" >0.446</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x188.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.540<sup>***</sup></td><td align="center" valign="middle" >0.581<sup>***</sup></td><td align="center" valign="middle" >0.621<sup>***</sup></td><td align="center" valign="middle" >0.661<sup>***</sup></td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x189.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.456<sup>***</sup></td><td align="center" valign="middle" >0.411<sup>*</sup></td><td align="center" valign="middle" >0.367</td><td align="center" valign="middle" >0.323</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x190.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.360<sup>**</sup></td><td align="center" valign="middle" >0.221</td><td align="center" valign="middle" >0.081</td><td align="center" valign="middle" >−0.058</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x191.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.563<sup>***</sup></td><td align="center" valign="middle" >0.626<sup>**</sup></td><td align="center" valign="middle" >0.689<sup>*</sup></td><td align="center" valign="middle" >0.753</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x192.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.468<sup>***</sup></td><td align="center" valign="middle" >0.435.</td><td align="center" valign="middle" >0.403</td><td align="center" valign="middle" >0.371</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x193.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >0.763</td><td align="center" valign="middle" >0.454</td><td align="center" valign="middle" >0.278</td><td align="center" valign="middle" >0.1856</td></tr><tr><td align="center" valign="middle" >Estimated <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x194.png" xlink:type="simple"/></inline-formula></td><td align="center" valign="middle" >1.053</td><td align="center" valign="middle" >2.107</td><td align="center" valign="middle" >3.160</td><td align="center" valign="middle" >4.214</td></tr><tr><td align="center" valign="middle" >F-Statistic with df = (5, 94)</td><td align="center" valign="middle" >60.71<sup>***</sup></td><td align="center" valign="middle" >15.61<sup>***</sup></td><td align="center" valign="middle" >7.227<sup>***</sup></td><td align="center" valign="middle" >4.286<sup>*</sup></td></tr></tbody></table></table-wrap><p>Significant codes: <sup>***</sup> p-value &lt; 0.00001, <sup>**</sup>p-value &lt; 0.001, <sup>*</sup>p-value &lt; 0.01, “.”(p-value &lt; 0.05).</p><p>To demonstrate this result, we make use Monte-Carlo procedure and randomly sample 36 observations from the simulate data <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula> used for Scenario 1<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x196.png" xlink:type="simple"/></inline-formula>. We then fit the data to the Guastello’s cusp regression model. We use the same criteria (significant<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x196.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x197.png" xlink:type="simple"/></inline-formula>, plus either <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x196.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x197.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x198.png" xlink:type="simple"/></inline-formula> or<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x196.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x197.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x198.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x199.png" xlink:type="simple"/></inline-formula>) to assess the detection of a cusp. Among 1000 repeats of the Monte-Carlo simulations with sample size<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x195.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x196.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x197.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x198.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x199.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x200.png" xlink:type="simple"/></inline-formula>, we found 833 times (83.3%) significant. This result indicates that the power analysis of the simulation method we proposed is close to 85%. In another word, the method we proposed is slightly conservative, which is good for research design. The template is designed so that author affiliations are not repeated each time for multiple authors of the same affiliation. Please keep your affiliations as succinct as possible (for example, do NOT post your job titles, positions, academic degrees, zip codes, names of building/street/district/province/state, etc.). This template was designed for two affiliations.</p></sec></sec><sec id="s4_2"><title>4.2. Verification with Published Data</title><p>The best approach to demonstrate the validity of the simulation approach would be to test it with observed data. To use our approach, we need two sets of data from any reported study: parameter estimates as effect size <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x201.png" xlink:type="simple"/></inline-formula> and estimated mean error of model fitting<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x201.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x202.png" xlink:type="simple"/></inline-formula>. However, we experienced difficulties in finding such data from all the studies we accessed in the published literature database. For example, all <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x201.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x202.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x203.png" xlink:type="simple"/></inline-formula> coefficients were reported by all studies but <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x201.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x202.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x203.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x204.png" xlink:type="simple"/></inline-formula> was not; furthermore, data-model fitting error fitting <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x201.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x202.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x203.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x204.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x205.png" xlink:type="simple"/></inline-formula> was never reported in any of the published studies using Guastelle’s cusp polynomial regression method. Fortunately, one author of this paper [<xref ref-type="bibr" rid="scirp.51467-ref12">12</xref>] published a study that modeled early sexual initiation among young adolescents using this polynomial regression approach.</p><p>Briefly, in Chen’s study participants were 469 virgins in the control group for a randomized controlled trial to assess the effect of an HIV behavioral prevention intervention program [<xref ref-type="bibr" rid="scirp.51467-ref22">22</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref23">23</xref>] . The participants in grade 6 in the Bahamian public schools were randomly assigned to receive either intervention or control conditions. They were followed every 6 months up to 24 months at the time when the analysis was conducted. A participant was categorized as having initiated sex if he or she had the first penile-vagina sexual intercourse during the follow-up period. In addition to sexual initiation, the likelihood to initiate sex was also assessed using a 5-point rating scale with 1 = very unlikely to have sex in the next 6 months and 5 = very likely to have sex. A sexual progression index (SPI) was thus created as the dependent variable for modeling analysis was defined as the first time. SPI = 1 for participants who never had sex and reported very unlikely to have sex; SPI = 2 for participants who never had sex but unsure if they are going to have sex in the next 6 months; SPI = 3 for participants who never had sex but reported very like to have sex in the next 6 months; and SPI = 4 for participants who initiated sex. In addition to SPI, age was used as the asymmetry variable<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x206.png" xlink:type="simple"/></inline-formula>, and self-efficacy not to have sex (scale score based on 5 items) was used as the bifurcation<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x206.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x207.png" xlink:type="simple"/></inline-formula>.</p><p>To verify the simulation-based method, the parameter effect size estimates were obtained from the paper with<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x208.png" xlink:type="simple"/></inline-formula>, and the data-model fitting error <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x208.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x209.png" xlink:type="simple"/></inline-formula> was obtained by accessing to the original computing records. With these estimates, the simulation-based approach in Section 3.2 is applied. <xref ref-type="fig" rid="fig4">Figure 4</xref> presents the sample size-power curve. From the figure it can be seen that the estimated sample size is 153 to achieve 85% power. This sample size is much smaller than the sample <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x208.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x209.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x210.png" xlink:type="simple"/></inline-formula> in the original study.</p></sec></sec><sec id="s5"><title>5. Discussions</title><p>In the case where analytical solution to power analysis and sample size determination is difficult, simulation represents an ideal alternative as recommended in [<xref ref-type="bibr" rid="scirp.51467-ref16">16</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref17">17</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref24">24</xref>] . In this paper, we reported a novel simulation- based approach we developed to estimate the statistical power and to compute sample size for Gustello’s polynomial cusp catastrophe model. The method was developed based on statistical power theory and our understanding of Guastello’s cusp polynomial regression modeling approach. The computing method is programmed using the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x211.png" xlink:type="simple"/></inline-formula> software. Results from 1000 repeats of Monte Carlo simulation and empirical data analysis suggest that the method we proposed is valid and can be used in practice to conduct power analysis and to estimate sample size for Guastello polynomial cusp modeling method.</p><p>With this approach, researchers can compute statistical power and estimate sample size if they plan to conduct cusp modeling analysis using Gustallo’s polynomial regression method. A detailed introduction to the method can be found in [<xref ref-type="bibr" rid="scirp.51467-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref21">21</xref>] . Data needed for our methods included parameter effect size estimates for the intercept and five model parameters <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x212.png" xlink:type="simple"/></inline-formula> and a data-model fitting error <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x212.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x213.png" xlink:type="simple"/></inline-formula> or its estimate. With the specification of these data, power can be computed for any given sample sizes. In addition to computer power, the commonly used sample size-power curve can be generated to provide a visual presentation between sample size and statistical power. With such power curve, sample size can be estimated for specified power in design and analysis data from cusp catastrophe model.</p><p>To make the presentation easier, we confined this novel simulation approach to the situation of one regressor for each control variable in the cusp model. This approach can be easily adopted and extended to multiple regressors for each of the asymmetric <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x214.png" xlink:type="simple"/></inline-formula> and bifurcation <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x214.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x215.png" xlink:type="simple"/></inline-formula> variables where the Guastello’s cusp polynomial regression model would need to be extended.</p><fig id="fig4"  position="float"><label><xref ref-type="fig" rid="fig4">Figure 4</xref></label><caption><title> Power curve for Chen et al. (2010). The estimated sample size for power of 0.85 is 153</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/1-1240370x216.png"/></fig><p>More and more data suggest the utility of cusp modeling approach in characterizing a number of human behaviors, particularly health risk behaviors, such as tobacco smoking, alcohol consumption, hardcore drug use, dating violence, and unprotected sex [<xref ref-type="bibr" rid="scirp.51467-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref11">11</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref14">14</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref21">21</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref25">25</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref26">26</xref>] . The methods we reported in this paper provide a useful tool for researchers to more effectively design their research to investigate these risk behaviors and to assess intervention programs for risk reduction.</p><p>By conducting this study, we also note that previous studies published in the literature do not report adequate information for power analysis. We highly recommend that journal editors ask authors to report all parameter estimates, including<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x217.png" xlink:type="simple"/></inline-formula>, and data-model fitting error (mean square of error). In addition to power analysis and sample size estimation, such data are also useful for readers to statistically assess appropriateness of the reported results.</p><p>There are a number of strengths with the method we present in this study. The principle and the computing process are not difficult to follow; the data used for the computing can be obtained; the computing software is written with<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/1-1240370x218.png" xlink:type="simple"/></inline-formula>, available from the authors by request for collaboration; and the computing does not require much time (several seconds to half minutes). We are encouraged on the results from this research and work on extending the results into stochastic catastrophe model in [<xref ref-type="bibr" rid="scirp.51467-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.51467-ref19">19</xref>] . Despite many advantages, further application of the method in practice is needed.</p></sec><sec id="s6"><title>Acknowledgements</title><p>This research was support in part by two NIH grants, one from the National Institute On Drug Abuse (NIDA, R01 DA022730, PI: Chen X) and another from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD, R01HD075635, PIs: Chen X and Chen D).</p></sec></body><back><ref-list><title>References</title><ref id="scirp.51467-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Thom, R. (1975) Structural Stability and Morphogenesis. Benjamin-Addison-Wesley, New York.</mixed-citation></ref><ref id="scirp.51467-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Thom, R. and Fowler, D.H. (1975) Structural Stability and Morphogenesis: An Outline of a General Theory of Models. W. A. Benjamin, Michigan.</mixed-citation></ref><ref id="scirp.51467-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Cobb, L. and Ragade, R.K. (1978) Applications of Catastrophe Theory in the Behavioral and Life Sciences. Behavioral Science, 23, 291-419. http://dx.doi.org/10.1002/bs.3830230511</mixed-citation></ref><ref id="scirp.51467-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Cobb, L. and Watson, B. (1980) Statistical Catastrophe Theory: An Overview. Mathematical Modelling, 1, 311-317.  
http://dx.doi.org/10.1016/0270-0255(80)90041-X</mixed-citation></ref><ref id="scirp.51467-ref5"><label>5</label><mixed-citation publication-type="other" xlink:type="simple">Cobb, L. and Zacks, S. (1985) Applications of Catastrophe Theory for Statistical Modeling in the Biosciences. Journal of the American Statistical Association, 80, 793-802. http://dx.doi.org/10.1080/01621459.1985.10478184</mixed-citation></ref><ref id="scirp.51467-ref6"><label>6</label><mixed-citation publication-type="other" xlink:type="simple">Guastello, S.J. (1982). Moderator Regression and the Cusp Catastrophe: Application of Two-Stage Personnel Selection, Training, Therapy and Program Evaluation. Behavioral Science, 27, 259-272. http://dx.doi.org/10.1002/bs.3830270305</mixed-citation></ref><ref id="scirp.51467-ref7"><label>7</label><mixed-citation publication-type="other" xlink:type="simple">Guastello, S.J. (1989) Catastrophe Modeling of the Accident Processes: Evaluation of an Accident Reduction Program Using the Occupational Hazards Survey. Accident Analysis and Prevention, 21, 61-77. 
http://dx.doi.org/10.1016/0001-4575(89)90049-3</mixed-citation></ref><ref id="scirp.51467-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Grasman, R.P., van der Mass, H.L. and Wagenmakers, E. (2009) Fitting the Cusp Catastrophe in R: A Cusp Package Primer. Journal of Statistical Software, 32, 1-27.</mixed-citation></ref><ref id="scirp.51467-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Clair, S. (1998) A Cusp Catastrophe Model for Adolescent Alcohol Use: An Empirical Test. Nonlinear Dynamics, Psychology, and Life Sciences, 2, 217-241. http://dx.doi.org/10.1023/A:1022376002167</mixed-citation></ref><ref id="scirp.51467-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Mazanov, J. and Byrne, D.G. (2006) A Cusp Catastrophe Model Analysis of Changes in Adolescent Substance Use: Assessment of Behavioural Intention as a Bifurcation Variable. Nonlinear Dynamics, Psychology, and Life Sciences, 10, 445-470.</mixed-citation></ref><ref id="scirp.51467-ref11"><label>11</label><mixed-citation publication-type="other" xlink:type="simple">Guastello, S.J., Aruka, Y., Doyle, M. and Smerz, K.E. (2008) Cross-Cultural Generalizability of a Cusp Catastrophe Model for Binge Drinking among College Students. Nonlinear Dynamics, Psychology and Life Sciences, 12, 397-407.</mixed-citation></ref><ref id="scirp.51467-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Chen, X., Lunn, S., Harris, C., Li, X., Deveaux, L., Marshall, S., et al. (2010) Modeling Early Sexual Initiation among Young Adolescents Using Quantum and Continuous Behavior Change Methods: Implications for HIV Prevention. Nonlinear Dynamics, Psychology and Life Sciences, 14, 491-509.</mixed-citation></ref><ref id="scirp.51467-ref13"><label>13</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Wagner</surname><given-names> C.M. </given-names></name>,<etal>et al</etal>. (<year>2010</year>)<article-title>Predicting Nursing Turnover with Catastrophe Theory</article-title><source> Journal of Advanced Nursing</source><volume> 66</volume>,<fpage> 2071</fpage>-<lpage>2084</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.51467-ref14"><label>14</label><mixed-citation publication-type="other" xlink:type="simple">Chen, X., Lunn, S., Deveaus, L., Li, X., Brathwaite, N., Cottrell, L. and Stanton, B. (2008) A Cluster Randomized Controlled Trial of an Adolescent HIV Prevention Program among Bahamian Youth: Effect at 12 Months Post-Intervention. AIDS and Behavior, 13, 495-508.</mixed-citation></ref><ref id="scirp.51467-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Cohen, J. (1988) Statistical Power Analysis for the Behavioral Sciences. 2nd Edition, Lawrence Berbaum Associates, Hillsdale.</mixed-citation></ref><ref id="scirp.51467-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Chow, S., Shao, J. and Wang, H. (2008) Sample Size Calculations in Clinical Research. 2nd Edition, Chapman and Hall/CRC, Boca Raton.</mixed-citation></ref><ref id="scirp.51467-ref17"><label>17</label><mixed-citation publication-type="other" xlink:type="simple">Chen, D.G. and Peace, K.E. (2011) Clinical Trial Data Analysis Using R. Chapman and Hall/CRC, Boca Raton.</mixed-citation></ref><ref id="scirp.51467-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Saunders, P.T. (1980) An Introduction to Catastrophe Theory. Cambridge University Press, Cambridge. 
http://dx.doi.org/10.1017/CBO9781139171533</mixed-citation></ref><ref id="scirp.51467-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Hartelman, A.I. (1997) Stochastic Catastrophe Theory. University of Amsterdam, Amsterdam.</mixed-citation></ref><ref id="scirp.51467-ref20"><label>20</label><mixed-citation publication-type="other" xlink:type="simple">Iacus, S.M. (2008) Simulation and Inference for Stochastic Differential Equations with R Examples. Springer, Berlin.  
http://dx.doi.org/10.1007/978-0-387-75839-8</mixed-citation></ref><ref id="scirp.51467-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Guastello, S.J. and Gregson, A.M. (2011) Nonlinear Dynamic Systems Analysis for the Behavioral Sciences Using Real Data. CPC Press, Boca Raton.</mixed-citation></ref><ref id="scirp.51467-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Gong, J., Stanton, B., Lunn, S., Devearus, L., Li, X., Marshall, S., Brathwaite, N.V., Cottrell, L., Harris, C. and Chen, X. (2009) Effects through 24 Months of an HIV/AIDS Prevention Intervention Program Based on Protection Motivation Theory among Preadolescents in the Bahamas. Pediatrics, 123, 917-928.  
http://dx.doi.org/10.1542/peds.2008-2363</mixed-citation></ref><ref id="scirp.51467-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Chen, X., Stanton, S., Chen, D.G. and Li, X. (2013) Is Intention to Use Condom a Linear Process? Cusp Modeling and Evaluation of an HIV Prevention Intervention Trial. Nonlinear Dynamics, Psychology and Life Sciences, 17, 385-403.</mixed-citation></ref><ref id="scirp.51467-ref24"><label>24</label><mixed-citation publication-type="other" xlink:type="simple">Bolker, B. (2008) Ecological Models and Data in R. Princeton University Press, Princeton.</mixed-citation></ref><ref id="scirp.51467-ref25"><label>25</label><mixed-citation publication-type="other" xlink:type="simple">Mazanov, J. and Byrne, D.G. (2008) Modeling Change in Adolescent Smoking Behavior: Stability of Predictors across Analytic Models. British Journal of Health Psychology, 13, 361-379. http://dx.doi.org/10.1348/135910707X202490</mixed-citation></ref><ref id="scirp.51467-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">West, R. and Sohal, T. (2006) “Catastrophic” Pathways to Smoking Cessation: Findings from National Survey. British Medical Journal, 332, 458-460. http://dx.doi.org/10.1136/bmj.38723.573866.AE</mixed-citation></ref></ref-list></back></article>