Peripheral corneal inflammatory lesions are a group of conditions with similar signs and symptoms. Limbal and perilimbal injection, corneal neovascularization, corneal infiltrate, and anterior chamber inflammation are all findings commonly seen. The identification of a correct diagnosis begins with a complete history and physical exam along with necessary medical and/or surgical therapies. We report a case of unilateral peripheral corneal foreign body accompanied by injection, corneal neovascularization, and intraocular inflammation.

A nine-year-old boy presented to the general ophthalmologist with a several week history of redness, photophobia and occasional foreign body sensation in the right eye. The patient’s history was significant for playing outside on a windy day a few days prior to symptom development. Upon evaluation, uncorrected visual acuity (UCVA) was 20/25 in the right eye and 20/20 in the left. Slit lamp examination revealed anterior chamber inflammation with a dark brown lesion in the superotemporal cornea of the right eye. B-scan ultrasound was performed and revealed no foreign body. The patient was diagnosed with acute anterior uveitis with peripheral anterior synechiae. He was treated with prednisolone acetate 1% ophthalmic drops four times a day; cyclopentolate 1% ophthalmic drops twice a day and erythromycin ointment.

One week later, the patient noticed some improvement of his symptoms. Visual acuity was unchanged and gonioscopy revealed a pigmented lesion within the temporal corneal stroma, not extending beyond the endothelium. The pigmented area was no longer considered to be a peripheral anterior synechiae, and the differential diagnosis was expanded to include peripheral ulcerative keratitis, phlyctenulosis, and pigmented neoplasm, in addition to corneal foreign body. The patient was referred to a corneal specialist for further evaluation and treatment.

The patient was seen in our clinic two days later. Right UCVA was 20/20-2 and left UCVA was 20/15-2. Slit lamp examination of the right cornea revealed a 1.4 mm by 2 mm lesion at the ten o’clock position just inside the limbus (Figure 1(a)). The lesion had surrounding neovascular pannus and lipid deposition (Figure 1(b)). The anterior chamber was deep and quiet, and the iris was round and reactive. Given the patient’s age, wind exposure and incomplete response to treatment, a foreign body was suspected and evaluation under anesthesia (EUA) was scheduled.

Eight days later, the patient underwent EUA and a foreign body was identified in the peripheral cornea in the area of the pigmented lesion. The foreign body was estimated to extend 90% through the cornea. It was removed without complication and identified by pathology as a fragment of rock (Figure 2(a)). The patient was started

on gatifloxacin 0.5% ophthalmic drops four times a day. Prednisolone acetate 1% was continued four times a day and cyclopentolate was discontinued. At one week post-operatively, the redness and irritation of the right eye had resolved and UCVA was 20/20. A healing corneal wound is visible in the superotemporal cornea (Figure 2(b)).

We present a case of a pigmented peripheral corneal lesion associated with redness, irritation and foreign body sensation in a pediatric patient with history of sandstorm exposure. The diagnosis was confounded by the negative ultrasound. Ultrasound biomicroscopy has greater sensitivity than basic ultrasound for detecting ocular foreign bodies [1] [2] ; however, this could not be performed due to patient’s age and compliance. In this case, the diagnosis was not apparent until the fragment of rock was surgically identified and removed. This case illustrates an unusual presentation of a common ophthalmologic problem. This patient’s corneal lesion on slit-lamp examination appeared similar to several other ocular disorders, with which the patient was diagnosed and briefly treated for, prior to the EUA.

Initially, this patient was diagnosed with peripheral anterior synechiae secondary to acute anterior iritis, which is somewhat uncommon in the pediatric population. Inflammatory causes of anterior uveitis include juvenile idiopathic arthritis (JIA), psoriatic arthritis, and tubulointerstitial nephritis and uveitis syndrome (TINU). Infectious causes such as herpetic uveitis and lyme disease are also important to consider [3] . Figure 3(b) shows a slit-lamp image of an unrelated patient with peripheral anterior synechiae secondary to inflammation, with iris

irregularities, somewhat resembling the peripheral corneal lesion in our patient (Figure 1(a)). Peripheral ulcerative keratitis (PUK) was also entertained as a diagnosis, due to the presence of a peripheral corneal lesion associated with redness, irritation and photophobia. It is extremely rare in children, but classically manifests as peripheral corneal infiltrates that lead to epithelial breakdown and frank ulceration [4] [5] . A slit-lamp image of a true peripheral ulcerative keratitis (Figure 3(a)) showing limbal ulceration, conjunctival injection and pannus, is shown for comparison to our patient’s corneal foreign body slit-lamp image (Figure 1(a)). Both anterior uveitis and PUK were unlikely because of no previous history of systemic or infectious disease.

This patient was ultimately referred to us for a peripheral corneal lesion resembling phlyctenulosis. Phlyctenulosis is typically caused by a delayed (type IV) hypersensitivity reaction to staphylococcal blepharitis or tuberculosis (TB) [6] . Patients often have a history of chronic blepharitis and/or recurrent chalazia or TB exposure [7] . Corneal phlyctenules appear as white nodules at the limbus with surrounding dilated conjunctival blood vessels. Severe forms may present more centrally with accompanied corneal neovascularization. Figure 3(c) shows an example of a patient with phlyctenulosis to exemplify the similarities between this presentation and our patient’s corneal lesion. This patient had no history of blepharitis or risk factors for TB exposure, which makes phlyctenulosis a less likely cause of the corneal lesion in our patient.

In the end, the patient was found to have a corneal foreign body, likely acquired due to flying debris in the sandstorm. Corneal foreign body is consistent with this patient’s history of foreign body sensation, redness and irritation, and the examination findings of a pigmented corneal lesion. It is also consistent with the patient demographics, as 47% of emergency eye consults in children involve injuries that increase the risk for foreign body [8] . The foreign body was removed and the patient has recovered nicely. This case provides an interesting differential diagnosis of similarly appearing peripheral corneal lesions in a pediatric patient.