<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">ABB</journal-id><journal-title-group><journal-title>Advances in Bioscience and Biotechnology</journal-title></journal-title-group><issn pub-type="epub">2156-8456</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/abb.2014.513114</article-id><article-id pub-id-type="publisher-id">ABB-51324</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject></subj-group></article-categories><title-group><article-title>
 
 
  Modeling of Imperfect Data in Medical Sciences by Markov Chain with Numerical Computation
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>ahmoud</surname><given-names>Afshari</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Anoshirvan</surname><given-names>Ghaffaripour</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff2"><addr-line>Department of Statistics, College of Science, Yasouj University, Yasuj, Iran</addr-line></aff><aff id="aff1"><addr-line>Department of Statistics, College of Science, Persian Gulf University, Bushehr, Iran</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>afshar@pgu.ac.ir(AA)</email>;</corresp></author-notes><pub-date pub-type="epub"><day>07</day><month>11</month><year>2014</year></pub-date><volume>05</volume><issue>13</issue><fpage>1003</fpage><lpage>1008</lpage><history><date date-type="received"><day>24</day>	<month>August</month>	<year>2014</year></date><date date-type="rev-recd"><day>7</day>	<month>October</month>	<year>2014</year>	</date><date date-type="accepted"><day>1</day>	<month>November</month>	<year>2014</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  In this paper we consider sequences of observations that irregularly space at infrequent time in-tervals. We will discuss about one of the most important issues of stochastic processes, named Markov chains. We would reconstruct the collected imperfect data as a Markov chain and obtain an algorithm for finding maximum likelihood estimate of transition matrix. This approach is known as 
  <em>EM</em> algorithm, which includes main optimum advantages among other approaches, and consists of two phases: phase (maximization of target function). Continue the phase 
  <em>E</em> and 
  <em>M</em> to achieve the sequence convergence of matrix. Its limit is the optimal estimator. This algorithm, in contrast with other optimum algorithms which could be used for this purpose, is practicable in maximum likelihood estimate, and unlike to the methods which involve mathematical, is executable by computer. At the end we will survey the theoretical outcomes with numerical computation by using 
  <em>R</em> software.
 
</p></abstract><kwd-group><kwd>Markov Chain</kwd><kwd> Matrix Transition</kwd><kwd> Maximum Likelihood</kwd><kwd> &lt;i&gt;EM&lt;/i&gt; Algorithm</kwd><kwd> Missing Data</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Today, we humans are faced with many of the random variables and processes. One of the most important issues is the random process of Markov chain. Markov chain is often used to describe how the system changes over time. If we are able to model the system sufficiently to form a Markov chain model, we can then evaluate its various theoretical results through system analysis. In this article, the Matrix transition of Markov chain needed for imperfect observation within a given time is obtained through <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x11.png" xlink:type="simple"/></inline-formula> algorithm.</p><p>The <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x12.png" xlink:type="simple"/></inline-formula> algorithm has two stages: <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x13.png" xlink:type="simple"/></inline-formula>stage and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x14.png" xlink:type="simple"/></inline-formula> stage. This algorithm basically works in this way: We first take into consideration the initial value for the parameter which in this case is the transition matrix.</p><p>The full set of data (<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x15.png" xlink:type="simple"/></inline-formula>) is then reconstructed from missing data by estimation of these parameters in <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x16.png" xlink:type="simple"/></inline-formula> stage. In the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x17.png" xlink:type="simple"/></inline-formula> stage, the maximum likelihood of reconstructed data is maximized to get a new estimation of the parameter. Then, based on this new estimation, the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x18.png" xlink:type="simple"/></inline-formula> stage is repeated and we get the second estimation in the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x19.png" xlink:type="simple"/></inline-formula> stage. Finally, we continue this process as far as to get convergence estimates.</p><p>Dempstr [<xref ref-type="bibr" rid="scirp.51324-ref1">1</xref>] , Raj [<xref ref-type="bibr" rid="scirp.51324-ref2">2</xref>] , Johnson et al. [<xref ref-type="bibr" rid="scirp.51324-ref3">3</xref>] have obtained the value of maximum likelihood of the transition matrix for a sequence of observations.</p><p>Among the researchers who examined the issues of statistical inference of Markov chains and published articles in this area are Melichson [<xref ref-type="bibr" rid="scirp.51324-ref4">4</xref>] , Capee [<xref ref-type="bibr" rid="scirp.51324-ref5">5</xref>] , Chip [<xref ref-type="bibr" rid="scirp.51324-ref6">6</xref>] and Robert [<xref ref-type="bibr" rid="scirp.51324-ref7">7</xref>] .</p></sec><sec id="s2"><title>2. Modeling of Missing Data Based on Markov Chain</title><p>Following observations in <xref ref-type="table" rid="table1">Table 1</xref> are series of real data obtained about a kind of disease related to 3 patients at different times during 6 months in a hospital. We have missed some of the data because the patients have not attended the hospital in some cases. Number 1 indicates that the patient’s condition is satisfactory and number 2 shows the patients are in a very bad condition. The asterisk indicates that in a particular time point, the data has not been observed.</p><p>First, the patient’s condition is reported as: 1) Next month, no data are is available. Two months later the condition of that patient is reported as; 2) One month later his condition is reported as (1) again, and so on. We call such a set of data incomplete and it is shown as<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x20.png" xlink:type="simple"/></inline-formula>.</p><p>The incomplete data are collected against complete data (<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x21.png" xlink:type="simple"/></inline-formula>) which are gathered in all intervals between the first and the last observation.</p><p>Such a system can be modeled as a Markov chain with <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x22.png" xlink:type="simple"/></inline-formula> condition space and transition matrix P.</p><p>Generally, we will have <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula> if we consider <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula> as the number of condition change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula> at the time interval<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula>. <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula>as the transition probability from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula> condition at t time, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula>as the number of condition change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula> in a time unit for the whole <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula> data , and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula> as the element of matrix<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula>, i.e. condition change probability <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula> a stage from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x38.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x38.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x39.png" xlink:type="simple"/></inline-formula> condition. Having this fact in mind that with the incomplete data <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x38.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x39.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x40.png" xlink:type="simple"/></inline-formula> and the nonzero suitable initial transition matrix, there will be different complete data <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x38.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x39.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x41.png" xlink:type="simple"/></inline-formula> with their own probabilities, we estimate the transition matrix by the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x23.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x24.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x25.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x26.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x27.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x28.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x29.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x31.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x33.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x35.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x36.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x37.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x38.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x39.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x40.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x41.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x42.png" xlink:type="simple"/></inline-formula> algorithm as follows:</p><p>1—First, we change the specified incomplete data (<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x43.png" xlink:type="simple"/></inline-formula>) to complete data (<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x43.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x44.png" xlink:type="simple"/></inline-formula>) by considering a suitable amount for those intervals we have no observation and data. In other words, we reconstruct the complete data (<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x43.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x44.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x45.png" xlink:type="simple"/></inline-formula>) from the incomplete data.</p><p>2—We consider an initial value for an arbitrary non-zero element of the transfer matrix as<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x46.png" xlink:type="simple"/></inline-formula>.</p><p>3—We compute maximum likelihood of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x47.png" xlink:type="simple"/></inline-formula> observations with the initial transmission matrix <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x47.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x48.png" xlink:type="simple"/></inline-formula> as follows:</p><table-wrap id="table1" ><label><xref ref-type="table" rid="table1">Table 1</xref></label><caption><title> Missing data for patient</title></caption><table><tbody><thead><tr><th align="center" valign="middle" >Month</th><th align="center" valign="middle" >First patient</th><th align="center" valign="middle" >Second patient</th><th align="center" valign="middle" >Third patient</th></tr></thead><tr><td align="center" valign="middle"  colspan="2"  >0 1 1 * 2 2 3 1 4 * 5 * 6 1</td><td align="center" valign="middle" >1 * * 1 1 * *</td><td align="center" valign="middle" >1 2 * 1 * 2 *</td></tr></tbody></table></table-wrap><disp-formula id="scirp.51324-formula533"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x49.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.51324-formula534"><label>(1)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x50.png"  xlink:type="simple"/></disp-formula><p>4—We calculate the relative maximum (1) and show it as<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x51.png" xlink:type="simple"/></inline-formula>.</p><p>5—We repeat the steps 3 and 4 so much that the obtained matrix sequence <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x52.png" xlink:type="simple"/></inline-formula> gets to convergence <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x52.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x53.png" xlink:type="simple"/></inline-formula> matrix, in other words, our optimal estimate is<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x52.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x53.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x54.png" xlink:type="simple"/></inline-formula>.</p><p>The <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x55.png" xlink:type="simple"/></inline-formula> calculation and unique maximum <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x55.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x56.png" xlink:type="simple"/></inline-formula> are stated through the following theorem.</p><p>Theorem 1: Suppose that the matrix transition of the imperfect data in <xref ref-type="table" rid="table1">Table 1</xref> is<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x57.png" xlink:type="simple"/></inline-formula>, then</p><disp-formula id="scirp.51324-formula535"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x58.png"  xlink:type="simple"/></disp-formula><p>Proof: We assume the system at the time <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula> is in the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula> condition and at the next time interval it is in the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula> condition. The probability that a change occurs between conditions <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x63.png" xlink:type="simple"/></inline-formula> is done in the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x64.png" xlink:type="simple"/></inline-formula> time interval is computed according to the <xref ref-type="fig" rid="fig1">Figure 1</xref> provided that the system gets to n condition at <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x65.png" xlink:type="simple"/></inline-formula> from the starting point condition <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x66.png" xlink:type="simple"/></inline-formula> at<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x59.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x60.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x61.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x62.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x64.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x65.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x66.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x67.png" xlink:type="simple"/></inline-formula>.</p><p>First the system starting from m condition changes to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x68.png" xlink:type="simple"/></inline-formula> condition with the probability of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x69.png" xlink:type="simple"/></inline-formula> at the time unit of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x70.png" xlink:type="simple"/></inline-formula>. Then the system is likely to change to n condition at <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x70.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x71.png" xlink:type="simple"/></inline-formula> with the probability of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x70.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x71.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x72.png" xlink:type="simple"/></inline-formula>.</p><p>Suppose that we define <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x73.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x73.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x74.png" xlink:type="simple"/></inline-formula> as follows:</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x75.png" xlink:type="simple"/></inline-formula>: Cases in which changes from i to j condition occurs at<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x76.png" xlink:type="simple"/></inline-formula>.</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x77.png" xlink:type="simple"/></inline-formula>: Cases in which system starting from m condition at <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x77.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x78.png" xlink:type="simple"/></inline-formula> gets to n condition at<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x77.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x78.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x79.png" xlink:type="simple"/></inline-formula>.</p><p>Then we have:</p><disp-formula id="scirp.51324-formula536"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x80.png"  xlink:type="simple"/></disp-formula><p>It is clear that the probability of the number of condition changes between the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x81.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x82.png" xlink:type="simple"/></inline-formula> conditions along with a change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x83.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x84.png" xlink:type="simple"/></inline-formula> condition at the t time interval is equal to:<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x81.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x82.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x83.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x84.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x85.png" xlink:type="simple"/></inline-formula>.</p><p>So, the expected number of such condition changes in all time intervals is: <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula>because <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula> conditions repeatedly occurs at t intervals. Therefore, the expected number of transitions from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x89.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x89.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x90.png" xlink:type="simple"/></inline-formula> condition on the condition of observed data <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x89.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x90.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x91.png" xlink:type="simple"/></inline-formula> and Matrix transition <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x89.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x90.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x91.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x92.png" xlink:type="simple"/></inline-formula> accumulating on all observed data is obtained as follows:<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x86.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x87.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x88.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x89.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x90.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x91.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x92.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x93.png" xlink:type="simple"/></inline-formula>.</p><p>Theorem 2: Suppose that the matrix transition of the imperfect data in <xref ref-type="table" rid="table1">Table 1</xref> is<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x94.png" xlink:type="simple"/></inline-formula>, then there is a unique relative maximum with its entry is as follows:</p><fig id="fig1"  position="float"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> System gets to n condition</title></caption><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/3-7300968x95.png"/></fig><p>Proof:</p><disp-formula id="scirp.51324-formula537"><label>(2)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x97.png"  xlink:type="simple"/></disp-formula><p>Equation (2) has been obtained because the sum of entries in each line is one.</p><disp-formula id="scirp.51324-formula538"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x98.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.51324-formula539"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x99.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.51324-formula540"><label>(3)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x100.png"  xlink:type="simple"/></disp-formula><p>Adding Equation (3) on<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x101.png" xlink:type="simple"/></inline-formula>, we have:</p><disp-formula id="scirp.51324-formula541"><label>(4)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x102.png"  xlink:type="simple"/></disp-formula><p>By replacing Equation (4) in Equation (3), the proof is completed.</p><p>Remark: the fourth stage in algorithm is computed and algorithm is completed as the following:</p><p>1) We compute<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x103.png" xlink:type="simple"/></inline-formula>.</p><p>2) We compute matrix transition of first stage through this formula:</p><disp-formula id="scirp.51324-formula542"><graphic  xlink:href="http://html.scirp.org/file/3-7300968x104.png"  xlink:type="simple"/></disp-formula><p>The obtained <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x105.png" xlink:type="simple"/></inline-formula>s for all <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x105.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x106.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x105.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x106.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x107.png" xlink:type="simple"/></inline-formula> forms another matrix in the form of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x105.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x106.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x107.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x108.png" xlink:type="simple"/></inline-formula> for the next iteration.</p></sec><sec id="s3"><title>3. Numerical Computation</title><p>In this section, all the theories mentioned are surveyed on the <xref ref-type="table" rid="table1">Table 1</xref> through a program written in <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x109.png" xlink:type="simple"/></inline-formula> software.</p><p>For actual observations we have <xref ref-type="table" rid="table2">Table 2</xref> which is number of change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x110.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x111.png" xlink:type="simple"/></inline-formula> at the time interval<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x110.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x111.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x112.png" xlink:type="simple"/></inline-formula>.</p><p>Conducting computer program written on the bases of the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x113.png" xlink:type="simple"/></inline-formula> algorithm to estimate the matrix transition of the system and the original transition<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x114.png" xlink:type="simple"/></inline-formula>, we will have the following outputs:</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x115.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x118.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x121.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x124.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x127.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.51324-formula543"><label>(5)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x128.png"  xlink:type="simple"/></disp-formula><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x129.png" xlink:type="simple"/></inline-formula>Algorithm with another initial matrix will be:</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x130.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x133.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x136.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x139.png" xlink:type="simple"/></inline-formula>, ,</p><p><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x142.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.51324-formula544"><label>(6)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/3-7300968x143.png"  xlink:type="simple"/></disp-formula><p>As it is seen, the results (5) and (6) are the same in either way.</p></sec><sec id="s4"><title>4. Conclusions</title><p>In using the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x144.png" xlink:type="simple"/></inline-formula> algorithm, we are practically faced with some issues which should be focused to accelerate our work and save time.</p><p>1) If the initial transition matrix<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x145.png" xlink:type="simple"/></inline-formula>, which is arbitrarily chosen, is of a zero entry or the number of transitions from one condition to another one is zero in a unit of time, the corresponding entries of all produced matrices are zero, too. The initial matrix entries must be non-zero to avoid such condition.</p><p>2) Increase in the number of time units between successive observations increases the power of transition matrix. If the number of the observed condition changes is relatively low, the time interval between observations is high. Accordingly, with respect to time needed for computation, it is not economical to integrate all these to-</p><table-wrap id="table2" ><label><xref ref-type="table" rid="table2">Table 2</xref></label><caption><title> Condition change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x146.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x146.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x147.png" xlink:type="simple"/></inline-formula> at the time interval <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x146.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x147.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x148.png" xlink:type="simple"/></inline-formula> for missing data</title></caption><table><tbody><thead><tr><th align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x149.png" xlink:type="simple"/></inline-formula>: number of condition change from <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x150.png" xlink:type="simple"/></inline-formula> to <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x151.png" xlink:type="simple"/></inline-formula> at the time <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x152.png" xlink:type="simple"/></inline-formula></th></tr></thead><tr><td align="center" valign="middle" >Time 1 2 3 4 5 6</td></tr><tr><td align="center" valign="middle" ><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x153.png" xlink:type="simple"/></inline-formula> 1 * 4 1 * 1 <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x154.png" xlink:type="simple"/></inline-formula> 1 2 * * 1 * <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x155.png" xlink:type="simple"/></inline-formula> 1 4 * 1 * * <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x156.png" xlink:type="simple"/></inline-formula> * * * * * *</td></tr></tbody></table></table-wrap><p>gether in the analysis. Actually it is better to keep the maximum time interval at the level in which the probability of condition change is ignored. If the maximum time interval is too large, the increase in the time unit can be effective.</p><p>3) If the maximum time intervals are relatively low, the computation time of each stage is short, although different performances may be necessary before achieving convergence.</p><p>4) In practical computation, we have accepted that when the maximum difference between successive entries of transition matrix is smaller than a predetermined value, e.g.<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x157.png" xlink:type="simple"/></inline-formula>. In other words, convergence is achieved when for all values of i, j, and the given value for r, we have:<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x157.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/3-7300968x158.png" xlink:type="simple"/></inline-formula>.</p></sec><sec id="s5"><title>Acknowledgements</title><p>The support of Research Committee of Persian Gulf University is greatly acknowledged.</p></sec><sec id="s6"><title>NOTES</title></sec></body><back><ref-list><title>References</title><ref id="scirp.51324-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Dempstr, A.P., Larid, N.M. and Rubin, D.B. (1997) Maximum Likelihood from Incomplete Data via the EM Algorithm. 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