<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">PST</journal-id><journal-title-group><journal-title>Pain Studies and Treatment</journal-title></journal-title-group><issn pub-type="epub">2329-3268</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/pst.2015.32002</article-id><article-id pub-id-type="publisher-id">PST-57283</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Non-Operative Management of Hip Osteoarthritis
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>ay</surname><given-names>Marks</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Health and Behavior Studies, Program in Health Education, Teachers College and School of Health and Behavioral Sciences, Columbia University, New York, NY, USA</addr-line></aff><author-notes><corresp id="cor1">* E-mail:<email>rm226@columbia.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>19</day><month>06</month><year>2015</year></pub-date><volume>03</volume><issue>02</issue><fpage>7</fpage><lpage>22</lpage><history><date date-type="received"><day>26</day>	<month>May</month>	<year>2015</year></date><date date-type="rev-recd"><day>accepted</day>	<month>15</month>	<year>June</year>	</date><date date-type="accepted"><day>19</day>	<month>June</month>	<year>2015</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  This paper reviews several non-operative and non-pharmacologic management strategies advocated for alleviating the pain and disability experienced by people with hip osteoarthritis. It analyzes whether painful debilitating hip osteoarthritis, which has no effective cure and is often progressive, may be affected positively by non-operative interventions designed to control osteoarthritis pain. Finally, it provides an integrated plan of management for ameliorating hip osteoarthritis pain and disability in light of this knowledge.
 
</p></abstract><kwd-group><kwd>Hip Osteoarthritis</kwd><kwd> Intervention</kwd><kwd> Pain</kwd><kwd> Rehabilitation</kwd><kwd> Treatment</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>Osteoarthritis, the most common rheumatic disease [<xref ref-type="bibr" rid="scirp.57283-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref2">2</xref>] , is a chronic non-fatal condition with significant social and economic ramifications [<xref ref-type="bibr" rid="scirp.57283-ref1">1</xref>] . Highly prevalent among adults over the age of 75 [<xref ref-type="bibr" rid="scirp.57283-ref3">3</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] , the disease, which principally affects the articular cartilage lining of one or more synovial joints [<xref ref-type="bibr" rid="scirp.57283-ref8">8</xref>] , often causes unrelenting pain of the hand, knee, hip, foot, acromioclavicular and spinal joints [<xref ref-type="bibr" rid="scirp.57283-ref4">4</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref11">11</xref>] . When symptomatic, osteoar- thritis can consequently be extremely debilitating and can severely impair an individual’s ability to function physically without compromise, effort and excessive physical stress [<xref ref-type="bibr" rid="scirp.57283-ref6">6</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref10">10</xref>] . Recent estimates suggest that between 9 and 12 percent of elderly Americans with this condition will experience a decrement in their ability to function at the desired level in the context of their major activities of daily living. Of these individuals, approximately half or 1.5 million people will become totally disabled [<xref ref-type="bibr" rid="scirp.57283-ref6">6</xref>] .</p><p>Despite its significant impact, there is, as yet, no cure for osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref10">10</xref>] . While useful in restoring func- tion and ameliorating pain in severe cases of the disease, osteoarthritis may not be amenable to artificial joint- replacement surgery in all cases. Efforts to reduce pain accompanying the disease using analgesic medication and/or non-steroidal anti-inflammatory drugs (NSAIDS) [<xref ref-type="bibr" rid="scirp.57283-ref1">1</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref11">11</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref13">13</xref>] , frequently prove ineffective [<xref ref-type="bibr" rid="scirp.57283-ref4">4</xref>] , have adverse effects on articular cartilage metabolism [<xref ref-type="bibr" rid="scirp.57283-ref14">14</xref>] , or a variety of systemic toxic side-effects [<xref ref-type="bibr" rid="scirp.57283-ref15">15</xref>] . Further, since no drug reverses or delays the progression of osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref16">16</xref>] , their long-term efficacy has been challenged [<xref ref-type="bibr" rid="scirp.57283-ref17">17</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref20">20</xref>] . Fortunately, an array of adjunctive methods other than medications, or surgery, have the potential to reduce the pain and disability associated with osteoarthritis, with virtually no side effects [<xref ref-type="bibr" rid="scirp.57283-ref18">18</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref27">27</xref>] .</p><p>The objective of this paper is to outline the chief characteristics of osteoarthritic joint disease and some pertinent advances in our understanding of the effects of joint mechanics on joint physiology, and to consider how hip osteoarthritis might be managed effectively by a combination of physical and psychoeducational or behavioral therapeutic approaches. The paper describes the chief pathological and clinical features of osteoarthritis, some risk factors for joint destruction, and some conservative non-pharmacological therapies that might ameliorate osteoarthritic pain and disability. Although directed towards a conservative prescription for the management of hip osteoarthritis, one of the most important causes of pain and physical disability in the community [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref11">11</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref28">28</xref>] , the therapeutic rationale outlined should be applicable to other joint sites commonly affected by osteoarthritis, and described elsewhere such as the thumb, fingers, and hands [<xref ref-type="bibr" rid="scirp.57283-ref29">29</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref32">32</xref>] .<sup> </sup></p></sec><sec id="s2"><title>2. Clinical Pathology of Osteoarthritis</title><p>The chief features of osteoarthritic joint change, regardless of joint site, include the presence of focal or complete lesions of the articular cartilage lining the joint. As well, various degrees of bone remodelling within and around the bone adjacent to the articular cartilage lining is common. Other pathological features of the disease may include varying degrees of joint capsular and synovial membrane thickening, joint inflammation, ligament and tendon damage, and muscle pathology and atrophy [<xref ref-type="bibr" rid="scirp.57283-ref12">12</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref33">33</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref37">37</xref>] . There may also be deleterious disease- associated changes in the arteriol and venous circulation of the osteoarthritic joint capsular tissues and bone, plus abnormalities in the excitability of the nerve endings located in and around the joint tissues [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref38">38</xref>] .<sup> </sup></p><p>A joint disease of multiple dimensions, which may manifest differently from joint to joint [<xref ref-type="bibr" rid="scirp.57283-ref39">39</xref>] , and from one individual to another, the hallmark symptomatic feature of osteoarthritic destruction is pain with joint use. Other signs and symptoms associated with osteoarthritic joint damage include pain and joint stiffness after rest, diminished or excessive joint range of motion, joint tenderness, joint crepitus on motion, variable degrees of joint inflammation, and joint swelling [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref40">40</xref>] . There may also be a decline in joint stability and overall function, plus evidence of irreversible joint deformity and malalignment, plus decreased muscular strength, endurance and aerobic capacity [<xref ref-type="bibr" rid="scirp.57283-ref41">41</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref44">44</xref>] . Anxiety, depression, and impaired psychosocial functioning including a negative self-image are also frequent outcomes of osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref45">45</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref46">46</xref>] . Also common are impairments of general health, independence and less than optimal vitality [<xref ref-type="bibr" rid="scirp.57283-ref47">47</xref>] . Osteoarthritis is also frequently associated with hypertension and cardiovascular disease comorbidities [<xref ref-type="bibr" rid="scirp.57283-ref43">43</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref48">48</xref>] , which may further impair functional capacity. Although not usually fatal, the signs and symptoms of osteoarthritis may become progressively more severe with advancing disease. The disease may consequently reduce the ability of an individual to carry out his or her normal activities of daily living [<xref ref-type="bibr" rid="scirp.57283-ref49">49</xref>] and may limit work capacity and wage earnings quite considerably [<xref ref-type="bibr" rid="scirp.57283-ref50">50</xref>] . In the geriatric years, the disease may compromise quality of life [<xref ref-type="bibr" rid="scirp.57283-ref47">47</xref>] and the ability to live independently and carry out self-care activities [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] .</p><p>Fortunately, although the abnormal cell-matrix interactions of osteoarthritic cartilage usually result in an overall loss of its compressive stiffness and elasticity [<xref ref-type="bibr" rid="scirp.57283-ref51">51</xref>] , recent evidence suggests that as with cartilage cells exposed to cultures devoid of extracellular matrix, cartilage cells in areas of matrix damage divide and may migrate to form cell groups or clones [<xref ref-type="bibr" rid="scirp.57283-ref49">49</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref50">50</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref52">52</xref>] as part of an attempted reparative process [<xref ref-type="bibr" rid="scirp.57283-ref53">53</xref>] . In particular, because mechanical stimuli are essential for the growth and maintenance of cartilage and aberrant mechanical loading can lead to cartilage damage, careful mechanical manipulation of the cell micro-environment may foster tissue reconstitution and reduce matrix damage attributable to degradative enzymes by damaged cartilage cells [<xref ref-type="bibr" rid="scirp.57283-ref27">27</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref53">53</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref54">54</xref>] . This is supported by numerous loading studies ranging from immobilization to excessive weight bearing [<xref ref-type="bibr" rid="scirp.57283-ref54">54</xref>] and others that imply impaired muscle function might foster cartilage damage or render the bone beneath this tissue noncompliant [<xref ref-type="bibr" rid="scirp.57283-ref21">21</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref55">55</xref>] .<sup> </sup></p></sec><sec id="s3"><title>3. What Causes Osteoarthritis?</title><p>Although frequently a primary disorder with no known cause, the onset of osteoarthritis is believed to be strongly influenced by age, genetic, hormonal, metabolic and immunological factors [<xref ref-type="bibr" rid="scirp.57283-ref8">8</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref56">56</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref57">57</xref>] . In addition, biomechanical factors such as, obesity, congenital deformities, impaired muscle function [<xref ref-type="bibr" rid="scirp.57283-ref21">21</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref55">55</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref58">58</xref>] , aberrant joint loading [<xref ref-type="bibr" rid="scirp.57283-ref54">54</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref59">59</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref60">60</xref>] and trauma [<xref ref-type="bibr" rid="scirp.57283-ref61">61</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref63">63</xref>] are also thought to be important etiologic factors. Contributing indirectly to osteoarthritic joint destruction processes may be comorbid conditions that reduce or limit participation in regular activities, and debase joint circulation [<xref ref-type="bibr" rid="scirp.57283-ref48">48</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref43">43</xref>] . Fear, anxiety or depressive reactions to stressful life events [<xref ref-type="bibr" rid="scirp.57283-ref4">4</xref>] , may also impact upon physical activity levels and movement patterns which foster the disease process. Regardless of systemic or biomechanical mechanisms, behavioral and psychosocial variables can frequently predict the impact of osteoarthritis more strongly than can the extent of damage apparent in the joint [<xref ref-type="bibr" rid="scirp.57283-ref28">28</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref58">58</xref>] . To the extent that the cartilage microenvironment is influenced by the individual’s surroundings, the contributory effects of the social and work environment on the disease onset should not be ignored or underestimated.</p></sec><sec id="s4"><title>4. Therapeutic Strategies</title><p>Given the multiplicity of determinants that may underlie the development of osteoarthritic joint disease, and the considerable potential for cartilage repair that may exist, non-pharmacological and non-operative interventions that carefully consider all possible pathogenic mechanisms may have the potential for reversing the disease process [<xref ref-type="bibr" rid="scirp.57283-ref64">64</xref>] . Even if this does not occur, they may possibly be quite impactful for reducing or minimizing functional limitations and disability, and pain, the health issues of most concern to patients [<xref ref-type="bibr" rid="scirp.57283-ref65">65</xref>] .</p><p>In particular, since osteoarthritis disease progression is greatly influenced by joint loading mechanisms [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] , eliminating the most detrimental forces falling on the joint surface is indicated. As well, improving the ability of the surrounding joint tissues to absorb, distribute and respond to harmful mechanical loading forces more physiologically, is likely to preserve optimal function and longevity of intact articular cartilage tissue, as well as the bone interfaces of affected joints, irrespective of causative mechanism [<xref ref-type="bibr" rid="scirp.57283-ref3">3</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] . Encouraging movements that facilitate joint nutrition might also be expected to promote some degree of cartilage repair or reversal of cartilage catabolism, while relieving pain and enhancing quality of life, especially during the early stages of the disease process [<xref ref-type="bibr" rid="scirp.57283-ref59">59</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref60">60</xref>] .</p><p>Interventions that impact favorably upon joint biomechanics and joint nutrition in this respect include the application of appropriate joint protection strategies, exercise regimens, dietary changes as indicated, and the application of a variety of physical modalities such as electrical muscle stimulation.</p><p>Given the chronic nature of the disease, which necessitates having patients assume responsibility for their joint protection strategies and adherence with their treatment programs to maximize function and prevent disability [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] , the present review will focus largely on therapies that the individual patient can and should be able to implement independently on a regular basis. Adjunctive therapies which are more passive and may require a therapist for their administration have been described elsewhere and include acupuncture, electroacupuncture, interferential current, laser therapy, manual therapies, shortwave diathermy, ultrasound, infrared radiation, pulsed electromagnetic fields and therapeutic touch [<xref ref-type="bibr" rid="scirp.57283-ref27">27</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref67">67</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref78">78</xref>] .</p></sec><sec id="s5"><title>5. Hip Osteoarthritis</title><p>At the hip, despite its generally favourable prognosis [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] , osteoarthritis of one or both joints, often causes considerable pain in the groin, anterior thigh, buttock and knee regions. In addition, stiffness after rest is common, and as the disease progresses, pain may be present at night, at rest, or following the adoption of a single static postural position for a lengthy period. Joint range of motion commonly decreases over time, and disability may increase, including many functional activities of daily living, such as getting up from a chair may be disturbed. Putting on socks and shoes, walking any distance on level ground, ascending and descending stairs in a reciprocating manner, and getting in and out of a car may all be increasingly challenging as well [<xref ref-type="bibr" rid="scirp.57283-ref79">79</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] . Independent foot care, various components of dressing, toileting and bathing, and sexual problems are expected to mirror the disease progression [<xref ref-type="bibr" rid="scirp.57283-ref81">81</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref82">82</xref>] .</p><p>Other features include associated decrements in walking speed coupled by increases in energy expenditure [<xref ref-type="bibr" rid="scirp.57283-ref83">83</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref84">84</xref>] , muscle weakness and muscle pathology [<xref ref-type="bibr" rid="scirp.57283-ref85">85</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref86">86</xref>] . The presence of abnormal muscle function [<xref ref-type="bibr" rid="scirp.57283-ref21">21</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref87">87</xref>] and recruitment patterns in this condition can also impair balance and postural control when ambulating, causing recurrent falls [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] . If left untreated, isolated areas of muscle spasm may contribute to the progression of this arthropathy, especially if the joint is loaded repetitively [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] , as in occupations such as farming [<xref ref-type="bibr" rid="scirp.57283-ref28">28</xref>] . The degree of handicap associated with hip osteoarthritis is correlated with the prevailing degree of disability and pain along with the social circumstances of the affected individual [<xref ref-type="bibr" rid="scirp.57283-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref88">88</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref89">89</xref>] .</p></sec><sec id="s6"><title>6. Hip Osteoarthritis Management</title><p>Although no specific therapy to halt the progression of hip osteoarthritis has been identified, repeated impact loads, microtrauma and/or abnormal static force concentrations on the articular surface of one or both hips that can cause the condition or contribute to its severity, can be mimimized by (1) reducing excessive joint loading, both static and dynamic; (2) diminishing any modifiable contributing factors to abnormal joint loading such as capsular contractures, muscle weakness, and muscle spasm, and anxiety and depression; (3) improving postural control and the individual’s ability to functional physically, socially, economically and vocationally without fatigue, and at all stages a combination of psycho-educational and physical intervention treatment approaches are appropriate [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] .</p><p>As with osteoarthritis at other joints, the specific combination of pyschoeducational and physical treatment approaches selected to manage the pain and disability of hip osteoarthritis should be based upon, an adequate assessment of the individual’s overall physical condition, the stage of the disease, the individual’s age, and an understanding of the individual’s personal goals. Work, recreational and social activities, as well as family relationships and other factors that might affect the prognosis of the disease, such as level of social support, should also be assessed. The disciplines involved in the individual patient’s management program should include physical therapists, occupational therapists, nurses and physiatrists as well as health educators. In recommending the most suitable types of therapies for the individual patient, the practitioner should consider the availability of resources for their recommendations, as well as the practicality and accessibility of the prescribed management requirements, including, personnel and equipment, as well as their known efficacy.</p></sec><sec id="s7"><title>7. Psychoeducational Interventions</title><p>Psychoeducational interventions, including both traditional educational or teaching activities and psychologically mediated interventions, are common forms of intervention applied alone, or in combination to help people with hip osteoarthritis to function more ably. This form of intervention aims at improving the life quality, psychological disposition, and individual autonomy of the client in the face of adverse events, and most commonly involves education directed towards self-management of the condition and/or cognitive-behavior therapy approaches [<xref ref-type="bibr" rid="scirp.57283-ref90">90</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] . Both approaches emphasize the learning of new skills and the voluntary adoption of appropriate behaviors that may foster more optimal disease self-management. While often focused on the application of information and problem solving, most self-management programs are quite comprehensive and also include training in relaxation and coping skills, and the rehearsal of these skills in the home and work environment [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref93">93</xref>] . Cognitive-behavioral therapy usually emphasizes pain control by heightening the individual’s understanding of the potentially deleterious interaction of negative emotions and cognitions with the physical aspects of pain. Clients are shown how to apply cognitive restructuring, diversion or relaxation skills to their every day lives [<xref ref-type="bibr" rid="scirp.57283-ref94">94</xref>] . Bradley and Alberts [<xref ref-type="bibr" rid="scirp.57283-ref92">92</xref>] concluded that cognitive-behavioral therapies and the Arthritis Self- Management Program [<xref ref-type="bibr" rid="scirp.57283-ref95">95</xref>] represented well-established treatments for ameliorating pain among patients with osteoarthritis, including hip osteoarthritis. There is also support for the effectiveness of direct social or psychological support as a potent psychobehavioral mediator that may benefit the person with hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref97">97</xref>] .<sup> </sup></p><sec id="s7_1"><title>7.1. Education<sup> </sup></title><p>For people with hip osteoarthritis, education about their condition, and their role in its management, is a vital first step [<xref ref-type="bibr" rid="scirp.57283-ref98">98</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref99">99</xref>] towards lessening their level of functional disability [<xref ref-type="bibr" rid="scirp.57283-ref100">100</xref>] and decreasing their pain [<xref ref-type="bibr" rid="scirp.57283-ref2">2</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref10">10</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref79">79</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref90">90</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref94">94</xref>] . Individuals with hip osteoarthritis receiving self-care education are also expected to visit physicians less often than those who do not, and to have lower drug intakes and drug toxicity [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref101">101</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref103">103</xref>] . They may experience an overall improvement in life quality [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] when compared to those receiving no form of education [<xref ref-type="bibr" rid="scirp.57283-ref90">90</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref94">94</xref>] . As well, adherence to recommendations may be greatly improved by education which enables more appropriate appraisals of the disease and that facilitates the patients’ coping, decision making and problem solving abilities [<xref ref-type="bibr" rid="scirp.57283-ref79">79</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] . In addition, enhancing patient confidence in their ability to succeed in implementing a self-management program in the face of disease unpredictability is of great potential benefit [<xref ref-type="bibr" rid="scirp.57283-ref100">100</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref104">104</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref105">105</xref>] .</p><p>A thoughtful educational program using the most up-to-date information may also allay anxiety and improve an individual’s attitude towards the disease and its management quite markedly [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref106">106</xref>] . Providing realistic information about the natural history of the disease and its generally relatively good prognosis are especially important [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] . However, while most traditional educational approaches that have been developed all seem to yield equivalent results [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] , tailored and personalized health education interventions, along with those that incorporate behavioral approaches, appear to be more efficacious than generic educational strategies alone, in maximizing the effectiveness of salient health messages for this group [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref104">104</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref107">107</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref108">108</xref>] . Specifically, active involvement of the patient in their own self-management program through the provision of tailored information and resources can foster the individual patient’s self-efficacy for carrying out the prescriptive interventions, which is crucial for securing optimal outcoms [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref104">104</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref108">108</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref110">110</xref>] . This behavioral approach is supported by Gecht et al. [<xref ref-type="bibr" rid="scirp.57283-ref111">111</xref>] who examined the exercise beliefs and participation in exercise activities of people with arthritis and found that the subject’s belief in the benefits of exercise and their self-efficacy for exercise were highly correlated.</p><p>It is also supported by the favourable outcomes reported by previous reviewers of arthritis self-management educational programs [<xref ref-type="bibr" rid="scirp.57283-ref21">21</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref90">90</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref94">94</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref95">95</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref101">101</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref103">103</xref>] . This is important because the disease is often very unpredictable [<xref ref-type="bibr" rid="scirp.57283-ref112">112</xref>] , and demands strict adherence to the prescribed self-management programs. For those with low literacy readable materials [<xref ref-type="bibr" rid="scirp.57283-ref113">113</xref>] , plus personalized booster sessions, relapse prevention interventions, and some form of ongoing personal contact and targeted feedback by an esteemed health professional is recommended [<xref ref-type="bibr" rid="scirp.57283-ref113">113</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref114">114</xref>] . The provision of ongoing professional contact plus regular reassessments can help to foster patient co-operation and prescribed program adherence as suggested by findings of Hopman-Rock and Westhoff [<xref ref-type="bibr" rid="scirp.57283-ref115">115</xref>] .</p><p>Also important for fostering adherence is the use of patient-provider contracts, enlisting family support, and having patients’ record details of their daily progress on a consistent basis [<xref ref-type="bibr" rid="scirp.57283-ref107">107</xref>] . As well, mutual decision making concerning goals of the management program is advocated [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] . A careful initial assessment of the individual patient’s health status, concerns, personal values and resources, as well as additional information about the patient’s daily routine, home environment, level of family support, and work status can enable the practitioner to provide a program of activities that can optimally reduce pain and promote maximal function [<xref ref-type="bibr" rid="scirp.57283-ref100">100</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref116">116</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref118">118</xref>] .</p><p>There is also evidence that receiving personalized professional advice on an ongoing basis according to need, community access to customized mass-produced self-help kits, video or audiotapes, printed matter [<xref ref-type="bibr" rid="scirp.57283-ref119">119</xref>] , and educational interventions delivered in group settings has a favorable impact on an individual’s self-management ability [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref97">97</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref104">104</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref107">107</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref114">114</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref120">120</xref>] . Alternately, having external forms of support, such as regular or periodic telephone access to health-care workers, dietary or sexual counsellors to discuss questions and concerns about the disease [<xref ref-type="bibr" rid="scirp.57283-ref118">118</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref121">121</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref123">123</xref>] , as well as having informational leaflets about community resources, can heighten a patient’s confidence about their ability to manage their disease.</p><p>Clearly, however, hip osteoarthritis patients may vary considerably in their ability and motivation as well as their preparedness to undertake self-management efforts [<xref ref-type="bibr" rid="scirp.57283-ref119">119</xref>] . The identification of arthritis subgroups and interventions that are specifically tailored to accommodate like needs are, however, predicted to enhance participation in, and responsiveness to, pain-coping skills training, exercise interventions, and other formal self-mana- gement training programs [<xref ref-type="bibr" rid="scirp.57283-ref124">124</xref>] . Moreover, to promote exercise behaviors, it may be necessary to acknowledge gender differences among men and women with osteoarthritis and to make recommendations accordingly [<xref ref-type="bibr" rid="scirp.57283-ref125">125</xref>] .</p></sec><sec id="s7_2"><title>7.2. Cognitively Mediated Interventions</title><p>Cognitive-behavioral therapies using the principle of behavior modification to alter negative cognitive processes [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref126">126</xref>] are found to produce clinically beneficial outcomes among people with osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref67">67</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref91">91</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref126">126</xref>] , especially if spouse-assisted [<xref ref-type="bibr" rid="scirp.57283-ref127">127</xref>] . Recent findings by Hampson et al. [<xref ref-type="bibr" rid="scirp.57283-ref128">128</xref>] also suggest fostering appropriate appraisals about the intensity of the condition can enable individuals with hip joint osteoarthritis to carry out active, rather than passive, coping strategies, which are predictive of depression, and poorer disease outcomes.</p><p>Cognitive strategies that can be directed to enhance optimal muscle function, as well as strategies that promote relaxation in general, while not extensively examined with respect to the hip joint per se, may prove beneficial for decreasing pain, improving mood and function [<xref ref-type="bibr" rid="scirp.57283-ref26">26</xref>] . Research by King et al. [<xref ref-type="bibr" rid="scirp.57283-ref26">26</xref>] and Rice [<xref ref-type="bibr" rid="scirp.57283-ref129">129</xref>] suggested biofeedback and relaxation techniques can potentially help to reduce the pain experience of walking re- education in those with both early and disabling hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref130">130</xref>] .</p><p>The use of voluntary muscle relaxation techniques along with deep breathing exercises to offset any excessive muscle tension may be equally useful in treating acutely painful hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref93">93</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref102">102</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref131">131</xref>] . In particular, Zimmerman [<xref ref-type="bibr" rid="scirp.57283-ref23">23</xref>] suggested that training patients to voluntarily relax and to consciously adjust any abnormal postural or motion habits might be a useful adjunctive measure for people with chronically painful hip osteoarthritis, because the disease chronicity often results in reactive muscle spasm, poor posture, abnormal joint motion, and further muscle spasm and pain. Zischke [<xref ref-type="bibr" rid="scirp.57283-ref132">132</xref>] supported this viewpoint by demonstrating significantly improved physical and emotional function in those subjects with osteoarthritis who used relaxation strategies as part of their physical treatment programs. This form of intervention is often overlooked though, even in current reports [<xref ref-type="bibr" rid="scirp.57283-ref118">118</xref>] , but may be very helpful. Simpson and Dickenson [<xref ref-type="bibr" rid="scirp.57283-ref133">133</xref>] point out emotional upsets frequently result in an exacerbation of those osteoarthritic symptoms, which can further impair function [<xref ref-type="bibr" rid="scirp.57283-ref134">134</xref>] .</p></sec></sec><sec id="s8"><title>8. Physical Interventions</title><sec id="s8_1"><title>8.1. Joint Rest</title><p>While a joint clearly needs regular loading to help maintain its integrity [<xref ref-type="bibr" rid="scirp.57283-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref88">88</xref>] , and complete bed rest, with the exception of periods of severe pain, may cause complications [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] , and is not advisable [<xref ref-type="bibr" rid="scirp.57283-ref135">135</xref>] , efforts to protect an osteoarthritic joint from excessive loading by temporarily unloading it with judicious rests has been advocated [<xref ref-type="bibr" rid="scirp.57283-ref59">59</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref60">60</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref106">106</xref>] . This is especially true if muscles controlling the affected joint fatigue easily, or are in spasm, or if the individual is experiencing inflammation or an acute flare up of the disease. Thus, although elderly arthritic patients automatically tend to rest more on a “worse day”, it may be prudent to advise patients with this condition that specific rest periods of 20 - 60 minutes duration may be of benefit, especially if they have been sleeping poorly and have considerable pain with weight bearing activities [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref135">135</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref136">136</xref>] .</p><p>Such rest periods allow the cartilage to rehydrate and an individual with hip osteoarthritis may benefit from positioning themselves in prone or in supine with a pillow under the affected buttock and a 10 - 20 lb weight supported by a sling from the knee to reduce the tendency towards hip flexion contractures [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] . It is possible that traction applied to the affected leg during rest periods may prove beneficial [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] . Although there is little scientific evidence that rest or joint unloading might be effective in preserving or improving the mobility and work capacity of persons with osteoarthritis, relief of pain is usually said to be proportional to the amount of protection from weight bearing [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] . Also, because muscles around a painful joint are thought to fatigue more readily than muscles of a healthy painfree joint, and can work more effectively if they are not fatigued, protection from weight bearing appear to influence the work capacity of individuals with hip osteoarthritis, as well as shock absorption during activities that involve impact loading [<xref ref-type="bibr" rid="scirp.57283-ref116">116</xref>] .</p><p>Treadwell and Mankin [<xref ref-type="bibr" rid="scirp.57283-ref60">60</xref>] also believe that rest can reduce or minimize joint inflammation and protect an inflamed osteoarthritic joint from further damage. Work by Palmoski et al. [<xref ref-type="bibr" rid="scirp.57283-ref137">137</xref>] in animal models lends some support to this belief. For all these reasons, Simpson and Dickenson [<xref ref-type="bibr" rid="scirp.57283-ref133">133</xref>] recommend that local joint rest by splinting to unload the joints or by the use of adaptive devices and aids. They also advise appropriate planning of activities and avoidance of prolonged or repetitive activities.</p></sec><sec id="s8_2"><title>8.2. Assistive Devices and Orthoses</title><p>It has been widely reported that people with hip osteoarthritis who have unsteady gait or advanced disease, may improve their functional capacity and acquire some protection from untoward mechanical perturbations of the affected joint through the use of crutches, canes, walkers, splints or braces [<xref ref-type="bibr" rid="scirp.57283-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref82">82</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref88">88</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref102">102</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref106">106</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref138">138</xref>] . It is further believed that footwear designed to absorb shock, shoes that give good support, shoes that have thin non-slip soles, or the use of corrective foot orthotics such as a heel lift in one shoe―if leg lengths are unequal―may prove beneficial, while dress aids, such as a long shoe horn or stocking stretcher, may help to facilitate those daily activities that require bending and reaching [<xref ref-type="bibr" rid="scirp.57283-ref81">81</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref88">88</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref102">102</xref>] .</p></sec><sec id="s8_3"><title>8.3. Ergonomic and Environmental Adaptations</title><p>A number of adaptations to the home environment such as changing the bedroom location or the type of flooring may further relieve some unwarranted hip joint stresses that could otherwise hasten hip joint damage [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] . Joint protection during functional activities may also be enhanced by the use of raised toilet seats, grab bars next to toilets and in tubs or shower facilities. Arm rests on chairs and higher chairs [<xref ref-type="bibr" rid="scirp.57283-ref81">81</xref>] may also prove beneficial for people with end stage hip osteoarthritis who are not candidates for surgery. Mobility and independence are specifically enhanced by means of a motorized scooter [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] or wheelchair [<xref ref-type="bibr" rid="scirp.57283-ref138">138</xref>] . Similarly, careful assessment and the appropriate modification(s) of an individual’s work situation, work schedule and/or recreational activities all impact favorably upon the outcome of their hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref139">139</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref140">140</xref>] .</p></sec><sec id="s8_4"><title>8.4. Appropriate Joint Use</title><p>To further limit osteoarthritic hip joint pain attributable to mechanical factors, people with hip osteoarthritis should be advised to avoid prolonged static activities, contact sports, repetitive high impact loading or over-ex- ercising. They should also try to carry out activities as ease and comfortable as possible, and avoid rapid walking [<xref ref-type="bibr" rid="scirp.57283-ref88">88</xref>] , sitting with the hip in marked abduction [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] , or needless stair climbing.</p><p>Hip joint stresses may also be lessened by limiting the weight of loads carried [<xref ref-type="bibr" rid="scirp.57283-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref7">7</xref>] , by splitting heavy loads and carrying them separately in each hand, or by carrying loads on the same side as an affected osteoarthritic hip. Exercising in a gravity-reduced environment, such as water or on a bicycle, avoiding stairs, and walking at speeds that do not produce pain is also advised [<xref ref-type="bibr" rid="scirp.57283-ref141">141</xref>] .</p></sec><sec id="s8_5"><title>8.5. Weight Control</title><p>The maintenance of an optimal body weight or the implementation of a weight reduction program for overweight or obese patients may reduce unwarranted stresses on an osteoarthritic hip joint [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] . While long-term maintenance of weight loss is rarely retained [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] a loss of weight in those who are obese is strongly advocated because this may not only help to decrease pain, but may also improve hip joint rotary mobility which is affected by the magnitude of one’s body mass index [<xref ref-type="bibr" rid="scirp.57283-ref142">142</xref>] . Another potential problem related to obesity that could be improved by having a lower body fat content is the rate at which important shock absorbing muscles of the lower limb fatigue absorb peak ground reaction forces that could otherwise destroy articular cartilage [<xref ref-type="bibr" rid="scirp.57283-ref143">143</xref>] , or cause greater axial loading than the hip joint can accommodate [<xref ref-type="bibr" rid="scirp.57283-ref144">144</xref>] . Interventions to obviate poor nutritional practices and promote activities that do not damage joints, especially in early life, along with weight-loss programs in adult life, may be especially important in efforts to prevent the disability of hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref145">145</xref>] . Alternately, while restricted food consumption has not been shown to minimize the development of human hip osteoarthritis, a five-year longitudinal study on the hip joints of dogs [<xref ref-type="bibr" rid="scirp.57283-ref146">146</xref>] recently indicated a greater frequency and severity of osteoarthritis in the ad libitum-fed group of dogs, compared to dogs whose feeding was restricted. This finding, although limited in its generalizability, should not be ignored.</p></sec><sec id="s8_6"><title>8.6. Exercise</title><p>Findings from several recent clinical trials have shown that in addition to rest and joint protection strategies for ameliorating osteoarthritic pain and disability, short periods of exercise designed to reduce or prevent muscle weakness and atrophy, maintain joint range of motion, and improve endurance is valuable [<xref ref-type="bibr" rid="scirp.57283-ref5">5</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref96">96</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref147">147</xref>] . While the implementation of exercises should not be stressful or injurious to the joints, especially in overweight or hypermobile individuals [<xref ref-type="bibr" rid="scirp.57283-ref34">34</xref>] , the once or twice daily performance of 3 - 6 carefully performed active hip range of motion exercises that preserves at least 20˚ - 30˚ of hip flexion, full extension and abduction is necessary for facilitating gait [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] . In addition to promoting or maintaining joint range of motion actively, passive stretching of the capsule [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] , muscles and joint [<xref ref-type="bibr" rid="scirp.57283-ref24">24</xref>] has been shown to restore joint range of motion in hip osteoarthritis. An additional finding of note was that the stretch on the tightened adductor longus muscle led to muscle hypertrophy and to an increased muscle glycogen content, increasing substantially the work capacity of the individual. Careful stretching exercises carried out on a bed, in a warm pool to increase range of motion, exercises done on a firm board sprinkled with powder to decrease friction and with the use of a foot support that rolls on casters and continuous passive motion exercises may be of further benefit [<xref ref-type="bibr" rid="scirp.57283-ref25">25</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref148">148</xref>] . The inactivation of myofascial trigger points in the hip area followed by home stretching exercises [<xref ref-type="bibr" rid="scirp.57283-ref149">149</xref>] may also be helpful in relieving the stress concentration of contractures which might affect cartilage adversely and cause pain and impaired joint metabolism and stiffness [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] . Stretching exercises that improve joint range of motion also improve the ability of muscle to contract more rapidly and absorb unexpected impacts more effectively [<xref ref-type="bibr" rid="scirp.57283-ref22">22</xref>] .</p><p>Since joint stiffness, pain, disability and muscle weakness are related in patients with hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref150">150</xref>] , a sensible approach to reducing hip joint pain and promoting hip function should also include a series of carefully graded non-weight bearing isometric strengthening exercises carried out on a daily basis to improve hip abductor and hip extensor muscle strength [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] and endurance [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] . Once muscle spasm and any evidence of joint inflammation have subsided, these exercises might be progressed to painfree isotonic exercises with 2 - 5 lb. weights performed thrice weekly.</p><p>Well designed non-weight bearing or partial weight bearing low-impact walking and conditioning exercises performed within the limits of pain and motion on a stationary bicycle, or in a warm pool (temperature 30˚C - 34˚C) [<xref ref-type="bibr" rid="scirp.57283-ref151">151</xref>] , plus dancing, golfing, Tai-Chi, yoga and swimming exercises in water [<xref ref-type="bibr" rid="scirp.57283-ref62">62</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref80">80</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref102">102</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref141">141</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref151">151</xref>] - [<xref ref-type="bibr" rid="scirp.57283-ref155">155</xref>] , have all been shown to promote functioning in those with no signs of acute inflammation. Additionally, to foster maximal functional ability, and prevent unexpected falls and fall injuries [<xref ref-type="bibr" rid="scirp.57283-ref156">156</xref>] , optimizing the flexibility and strength of all muscle groups needed for good posture, walking, rising to standing and lifting, including upper and body segment rotary movements is equally helpful [<xref ref-type="bibr" rid="scirp.57283-ref116">116</xref>] . The re-education of postural control and balance is critical [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] because falls, which can cause further traumatic hip joint damage, are so common in people with hip osteoarthritis [<xref ref-type="bibr" rid="scirp.57283-ref9">9</xref>] .</p><p>Conversely, unsupervised participation in non-medical health spas and fitness programs, high velocity land or water activities should be discouraged, as should high impact or contact sporting activities. Participation in carefully graded and supervised exercise programs specifically designed for people with arthritis, or hobbies that are adapted to an individuals’ condition and do not aggravate symptoms or increase hip contact pressures unduly, should be encouraged.</p><p>Unfortunately, with few exceptions, there is little evidence to support the valuable role of exercise in hip osteoarthritis. What evidence does exist suggests that less improvement will occur with hip osteoarthritis than with knee osteoarthritis in response to exercise alone [<xref ref-type="bibr" rid="scirp.57283-ref157">157</xref>] .</p></sec></sec><sec id="s9"><title>9. Physical Modalities</title><p>In addition to the use of joint sparing techniques, adaptive devices, ergonomic adaptations and exercises designed to lessen pain, the emphasis on pain reduction in osteoarthritis and its independent association with locomotor disability [<xref ref-type="bibr" rid="scirp.57283-ref158">158</xref>] has led to the widespread use of a number of pain-relieving therapeutic modalities. Some of these modalities have not been shown to be more effective than placebo [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref159">159</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref160">160</xref>] . However, to relieve pain transiently and to aid muscle relaxation particularly during an acute flare of the disease, and to treat associated inflammatory conditions such as bursitis or tendonitis, the benefits of ice therapy or transcutaneous electrical stimulation [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] cannot be discounted in the absence of any related empirical studies.</p><p>In mild sub-acute or chronic disease phases, such modalities, including hydrotherapy to facilitate therapeutic exercise and ambulation [<xref ref-type="bibr" rid="scirp.57283-ref161">161</xref>] , plus shortwave diathermy and ultrasound applications, which are less effective for relieving pain than for increasing tissue temperature of deep articular structures, may help to facilitate joint mobilization and stretching procedures needed to maintain or increase hip joint range of motion [<xref ref-type="bibr" rid="scirp.57283-ref66">66</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref161">161</xref>] . However, in the absence of well-designed controlled trials, the selection of any modality may have to be made empirically on an individual basis and in accordance with any safety risk [<xref ref-type="bibr" rid="scirp.57283-ref161">161</xref>] .</p></sec><sec id="s10"><title>10. Conclusions</title><p>Osteoarthritis, the most common form of arthritis, causes immeasurable suffering and pain in the older population. Generally, considered a progressive disease of one or more joints with multiple origins, efforts to minimize the rate of progression and severity using pharmacologic and/or surgical approaches are not always successful.</p><p>Management strategies designed with a view of optimizing joint physiology and joint integrity that take into consideration all potential contributing factors and pathological implications of the prevailing structural damage and dysfunction of the individual case can, however, be effective in relieving pain, restoring function and enhancing a patients’ ability to live independently, even in the face of ongoing joint destruction processes [<xref ref-type="bibr" rid="scirp.57283-ref138">138</xref>] [<xref ref-type="bibr" rid="scirp.57283-ref154">154</xref>] . Careful diagnostic assessments and well planned conservative management programs for the individual patient are found to markedly improve quality of life when compared to the absence of any well-designed self- management treatment program [<xref ref-type="bibr" rid="scirp.57283-ref36">36</xref>] . This suggests that the inordinate costs and magnitude of osteoarthritic disability could be markedly reduced by careful intervention, especially by well tailored and targeted secondary preventive strategies.</p><p>To be optimally effective, such strategies should be implemented at the earliest possible point in time and be continued throughout the life course of the patient, as required. A team approach with the patient playing an active role in their own self-care is highly recommended, as is a multi-component therapeutic program. Precautions to avoid unrealistic treatment goals that can lead to frustration, depression, misunderstanding, and inappropriate withdrawal from activities and family and consideration of the patient’s social, emotional and psychological needs, are also essential for the achievement of optimal outcomes. Also, because excessive loading of a painfree but affected osteoarthritic joint can potentially cause further joint damage if the protective pain reflex is inhibited [<xref ref-type="bibr" rid="scirp.57283-ref17">17</xref>] , or if a sensory deficit prevails [<xref ref-type="bibr" rid="scirp.57283-ref14">14</xref>] , it may be necessary to caution patients not to increase their activities of daily living unduly over any treatment period. Patients may also need to avoid carrying out rapid impact loading activities, even if they do experience pain relief, as this could negate potential treatment benefits. Finally, as at other joints, at the hip, it is recommended that both the physical and the psychological status of the patient be assessed periodically to determine dosage and menu of recommendations, and emphasis should be placed on improving self-management skills and adherence to programmatic recommendations.</p></sec></body><back><ref-list><title>References</title><ref id="scirp.57283-ref1"><label>1</label><mixed-citation publication-type="book" xlink:type="simple">Moskowitz, R.W. and Goldberg, V.M. (1988) Osteoarthritis. In Schumacher Jr., H.R., Ed., Primer on the Rheumatic Diseases, Arthritis Foundation, Atlanta, 171-176.</mixed-citation></ref><ref id="scirp.57283-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Mankin, H.J. and Treadwell, B.V. (1986) Osteoarthritis: A 1986 Update. Bulletin of the Rheumatic Diseases, 36, 173- 182.</mixed-citation></ref><ref id="scirp.57283-ref3"><label>3</label><mixed-citation publication-type="other" xlink:type="simple">Lawrence, R.C., Hochberg, M.C., Kelsey, J.L., McDuffie, F.C., Medsger Jr., T.A., Felts, W.R. and Shulman, L.E. (1989) Estimates of the Prevalence of Selected Arthritic and Musculoskeletal Diseases in the United States. Journal of Rheumatology, 16, 427-441.</mixed-citation></ref><ref id="scirp.57283-ref4"><label>4</label><mixed-citation publication-type="other" xlink:type="simple">Simon, L.S. (2000) Osteoarthritis: A Review. Clinical Cornerstone, 2, 26-37. 
http://dx.doi.org/10.1016/S1098-3597(99)90012-1</mixed-citation></ref><ref id="scirp.57283-ref5"><label>5</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Sack</surname><given-names> K.E. </given-names></name>,<etal>et al</etal>. (<year>1995</year>)<article-title>Osteoarthritis. A Continuing Challenge</article-title><source> Western Journal of Medicine</source><volume> 163</volume>,<fpage> 579</fpage>-<lpage>586</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref6"><label>6</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Yelin</surname><given-names> E. </given-names></name>,<etal>et al</etal>. (<year>1989</year>)<article-title>Impact of Musculoskeletal Conditions on the Elderly</article-title><source> Geriatric Medicine Today</source><volume> 8</volume>,<fpage> 103</fpage>-<lpage>118</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref7"><label>7</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Rudd</surname><given-names> E. </given-names></name>,<etal>et al</etal>. (<year>1985</year>)<article-title>Physiatric Management of Osteoarthritis</article-title><source> Clinics in the Rheumatic Diseases</source><volume> 11</volume>,<fpage> 433</fpage>-<lpage>445</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref8"><label>8</label><mixed-citation publication-type="other" xlink:type="simple">Rehman, Q. and Lane, N.E. (1999) Getting Control of Osteoarthritis Pain. An Update on Treatment Options. Postgraduate Medicine, 106, 127-134. http://dx.doi.org/10.3810/pgm.1999.10.1.707</mixed-citation></ref><ref id="scirp.57283-ref9"><label>9</label><mixed-citation publication-type="other" xlink:type="simple">Ling, S.M. and Bathon, J.M. (1998) Osteoarthritis in Older Adults. Journal of the American Society of Geriatrics, 46, 216-225. http://dx.doi.org/10.1111/j.1532-5415.1998.tb02543.x</mixed-citation></ref><ref id="scirp.57283-ref10"><label>10</label><mixed-citation publication-type="other" xlink:type="simple">Abyad, A. and Boyer, J.T. (1992) Arthritis and Aging. Current Opinion in Rheumatology, 4, 153-159. 
http://dx.doi.org/10.1097/00002281-199204000-00004</mixed-citation></ref><ref id="scirp.57283-ref11"><label>11</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>MacFarlane</surname><given-names> D. </given-names></name>,<etal>et al</etal>. (<year>1992</year>)<article-title>Osteoarthritis</article-title><source> The Practitioner</source><volume> 236</volume>,<fpage> 1061</fpage>-<lpage>1065</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref12"><label>12</label><mixed-citation publication-type="other" xlink:type="simple">Dieppe, P. (1990) Some Recent Approaches to Arthritis Research. Seminars in Arthritis and Rheumatism, 20, 2-11. 
http://dx.doi.org/10.1016/0049-0172(90)90043-F</mixed-citation></ref><ref id="scirp.57283-ref13"><label>13</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Schnitzer</surname><given-names> T.J. </given-names></name>,<etal>et al</etal>. (<year>1993</year>)<article-title>Osteoarthritis Treatment Update: Minimizing Pain While Limiting Patient Risk</article-title><source> Postgraduate Medicine</source><volume> 93</volume>,<fpage> 89</fpage>-<lpage>95</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref14"><label>14</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Felson</surname><given-names> D.T. </given-names></name>,<etal>et al</etal>. (<year>1993</year>)<article-title>The Course of Osteoarthritis and Factors That Affect It</article-title><source> Rheumatic Disease Clinics of North America</source><volume> 19</volume>,<fpage> 607</fpage>-<lpage>615</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref15"><label>15</label><mixed-citation publication-type="other" xlink:type="simple">Griffin, M.R., Brandt, K.D., Liang, M.H., Pincus, T. and Ray, W.A. (1995) Practical Management of Osteoarthritis. Integration of Pharmacologic and Nonpharmacologic Measures. Archives of Family Medicine, 4, 1049-1055. 
http://dx.doi.org/10.1001/archfami.4.12.1049</mixed-citation></ref><ref id="scirp.57283-ref16"><label>16</label><mixed-citation publication-type="other" xlink:type="simple">Brooks, P.M. and Day, R.O. (1991) Nonsteroidal Antiinflammatory Drugs: Differences and Similarities. New England Journal of Medicine, 324, 1716-1725. http://dx.doi.org/10.1056/NEJM199106133242407</mixed-citation></ref><ref id="scirp.57283-ref17"><label>17</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Tsang</surname><given-names> I.K. </given-names></name>,<etal>et al</etal>. (<year>1995</year>)<article-title>Update on Osteoarthritis</article-title><source> Canadian Family Physician</source><volume> 36</volume>,<fpage> 539</fpage>-<lpage>541</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref18"><label>18</label><mixed-citation publication-type="other" xlink:type="simple">Grimmer, K. (1992) A Controlled Double Blind Study Comparing the Effects of Strong Burst Mode TENS and High Rate TENS on Painful Osteoarthritic Knees. Australian Journal of Physiotherapy, 38, 49-56. 
http://dx.doi.org/10.1016/S0004-9514(14)60551-1</mixed-citation></ref><ref id="scirp.57283-ref19"><label>19</label><mixed-citation publication-type="other" xlink:type="simple">Lewis, B., Lewis, D. and Cumming, G. (1994) The Comparative Analgesic Efficacy of Transcutaneous Electrical Nerve Stimulation and a Non-Steroidal Anti-Inflammatory Drug for Painful Osteoarthritis. British Journal of Rheumatology, 33, 455-460. http://dx.doi.org/10.1093/rheumatology/33.5.455</mixed-citation></ref><ref id="scirp.57283-ref20"><label>20</label><mixed-citation publication-type="other" xlink:type="simple">Smith, C.R., Lewith, G.T. and Machin, D. (1983) TNS and Osteo-Arthritic Pain: Preliminary Study to Establish a Controlled Method of Assessing Transcutaneous Nerve Stimulation as a Treatment for the Pain Caused by Osteoarthrosis of the Knee. Physiotherapy, 69, 266-268.</mixed-citation></ref><ref id="scirp.57283-ref21"><label>21</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R. (1993) Muscles as a Pathogenic Factor in Osteoarthritis. Physiotherapy Canada, 79, 13-18. 
http://dx.doi.org/10.1016/S0031-9406(10)60533-0</mixed-citation></ref><ref id="scirp.57283-ref22"><label>22</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R. (1992) Peripheral Articular Mechanisms in Pain Production in Osteoarthritis. Australian Journal of Physiotherapy, 38, 289-298. http://dx.doi.org/10.1016/S0004-9514(14)60572-9</mixed-citation></ref><ref id="scirp.57283-ref23"><label>23</label><mixed-citation publication-type="other" xlink:type="simple">Zimmerman, M. (1989) Pain Mechanisms and Mediators in Osteoarthritis. Seminars in Arthritis and Rheumatism, 18, 22-29. http://dx.doi.org/10.1016/0049-0172(89)90012-7</mixed-citation></ref><ref id="scirp.57283-ref24"><label>24</label><mixed-citation publication-type="other" xlink:type="simple">Leivseth, G., Torstensson, J. and Reikeras, O. (1989) Effect of Passive Muscle Stretching in Osteoarthritis of the Hip. Clinical Science, 76, 113-117.</mixed-citation></ref><ref id="scirp.57283-ref25"><label>25</label><mixed-citation publication-type="other" xlink:type="simple">Langeland, N. (1972) Conservative Treatment with Active Exercises in Osteoarthritis of the Hip. Acta Orthopedica Scandinavica, 43, 118-125. http://dx.doi.org/10.3109/17453677208991250</mixed-citation></ref><ref id="scirp.57283-ref26"><label>26</label><mixed-citation publication-type="other" xlink:type="simple">King, A.C., Ahles, T.A., Martin, J.E. and White, R. (1984) EMG Biofeedback Controlled Exercise in Chronic Arthritic Knee Pain. Archives of Physical Medicine and Rehabilitation, 65, 341-343.</mixed-citation></ref><ref id="scirp.57283-ref27"><label>27</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Marks</surname><given-names> R. </given-names></name>,<etal>et al</etal>. (<year>1992</year>)<article-title>Physical Modalities and Articular Cartilage Repair</article-title><source> New Zealand Journal of Physiotherapy</source><volume> 20</volume>,<fpage> 17</fpage>-<lpage> 20</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref28"><label>28</label><mixed-citation publication-type="other" xlink:type="simple">Dieppe, P. (1993) Management of Osteoarthritis of the Hip and Knee Joints. Current Opinion in Rheumatology, 5, 487- 493. http://dx.doi.org/10.1097/00002281-199305040-00014</mixed-citation></ref><ref id="scirp.57283-ref29"><label>29</label><mixed-citation publication-type="other" xlink:type="simple">Estes, J.P., Bochenek, C. and Fasler, P. (2000) Osteoarthritis of the Fingers. Journal of Hand Therapy, 3, 108-123. 
http://dx.doi.org/10.1016/S0894-1130(00)80035-6</mixed-citation></ref><ref id="scirp.57283-ref30"><label>30</label><mixed-citation publication-type="other" xlink:type="simple">Burkholder, J.F. (2000) Osteoarthritis of the Hand: A Modifiable Disease. Journal of Hand Therapy, 13, 79-89. 
http://dx.doi.org/10.1016/S0894-1130(00)80032-0</mixed-citation></ref><ref id="scirp.57283-ref31"><label>31</label><mixed-citation publication-type="other" xlink:type="simple">Poole, J.U. and Pellegrini, V.D. (2000) Arthritis of the Thumb Basal Joint Complex. Journal of Hand Therapy, 13, 91- 100. http://dx.doi.org/10.1016/S0894-1130(00)80034-4</mixed-citation></ref><ref id="scirp.57283-ref32"><label>32</label><mixed-citation publication-type="other" xlink:type="simple">Lockard, M.A. (2000) Exercise for the Patient with Upper Quadrant Osteoarthritis. Journal of Hand Therapy, 13, 175-183. http://dx.doi.org/10.1016/S0894-1130(00)80040-X</mixed-citation></ref><ref id="scirp.57283-ref33"><label>33</label><mixed-citation publication-type="other" xlink:type="simple">Burr, B. and Schaffler, M.B. (1997) The Involvement of the Subchondral Mineralized Tissues in Osteoarthrosis: Quantitative Microscopic Evidence. Microscopy Research Technology, 15, 343-357. 
http://dx.doi.org/10.1002/(SICI)1097-0029(19970515)37:4&lt;343::AID-JEMT9&gt;3.0.CO;2-L</mixed-citation></ref><ref id="scirp.57283-ref34"><label>34</label><mixed-citation publication-type="other" xlink:type="simple">Altman, R.D. and Gray, R. (1995) Inflammation in Osteoarthritis. Clinics in the Rheumatic Diseases, 11, 353-365.</mixed-citation></ref><ref id="scirp.57283-ref35"><label>35</label><mixed-citation publication-type="other" xlink:type="simple">Brandt, K.D. (1997) Putting Some Muscle into Osteoarthritis. Annals of Internal Medicine, 127, 154-156. 
http://dx.doi.org/10.7326/0003-4819-127-2-199707150-00011</mixed-citation></ref><ref id="scirp.57283-ref36"><label>36</label><mixed-citation publication-type="other" xlink:type="simple">Threlkeld, J. and Currier, D.P. (1988) Osteoarthritis. Effects on Synovial Tissues. Physical Therapy, 68, 364-370.</mixed-citation></ref><ref id="scirp.57283-ref37"><label>37</label><mixed-citation publication-type="other" xlink:type="simple">Glasberg, M.R., Glasberg, J.R. and Jones, R.E. (1986) Muscle Pathology in Total Knee Replacement for Severe Osteoarthritis. Henry Ford Hospital Medical Journal, 34, 37-40.</mixed-citation></ref><ref id="scirp.57283-ref38"><label>38</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R., Quinney, H.A. and Wessel, J. (1993) Proprioceptive Sensibility in Women with Normal and Osteoarthritic Knee Joints. Clinical Rheumatology, 12, 170-175. http://dx.doi.org/10.1007/BF02231522</mixed-citation></ref><ref id="scirp.57283-ref39"><label>39</label><mixed-citation publication-type="other" xlink:type="simple">Acheson, R.M. and Oration, H. (1981) Epidemiology and the Arthritides. Annals of the Rheumatic Diseases, 4, 325- 334.</mixed-citation></ref><ref id="scirp.57283-ref40"><label>40</label><mixed-citation publication-type="other" xlink:type="simple">Thompson, J.A., Jennings, M.B. and Hodge, W. (1992) Orthotic Therapy in the Management of Osteoarthritis. Journal of the American Podiatric Medical Association, 82, 136-139. http://dx.doi.org/10.7547/87507315-82-3-136</mixed-citation></ref><ref id="scirp.57283-ref41"><label>41</label><mixed-citation publication-type="other" xlink:type="simple">White, S.H., Ludkowski, P.F. and Goodfellow, J.W. (1991) Anteromedial Osteoarthritis of the Knee. Journal of Bone and Joint Surgery, 73, 582-586.</mixed-citation></ref><ref id="scirp.57283-ref42"><label>42</label><mixed-citation publication-type="other" xlink:type="simple">Minor, M.A., Webel, R.R., Kay, D.R., Hewett, J.E. and Anderson, S.K. (1989) Efficacy of Physical Conditioning Exercise in Patients with Rheumatoid Arthritis and Osteoarthritis. Arthritis and Rheumatism, 32, 1396-1405. 
http://dx.doi.org/10.1002/anr.1780321108</mixed-citation></ref><ref id="scirp.57283-ref43"><label>43</label><mixed-citation publication-type="other" xlink:type="simple">Philbin, E.F., Groff, G.D., Ries, M.D. and Miller, T.E. (1995) Cardiovascular Fitness and Health in Patients with End-Stage Osteoarthritis. Arthritis and Rheumatism, 38, 799-805. http://dx.doi.org/10.1002/art.1780380613</mixed-citation></ref><ref id="scirp.57283-ref44"><label>44</label><mixed-citation publication-type="other" xlink:type="simple">Beals, C.A., Lampman, R.M., Banwell, B.F., Braunstein, E.M., Albers, J.W. and Castor, C.W. (1985) Measurement of Exercise Tolerance in Patients with Rheumatoid and Osteoarthritis. Journal of Rheumatology, 2, 458-461.</mixed-citation></ref><ref id="scirp.57283-ref45"><label>45</label><mixed-citation publication-type="other" xlink:type="simple">Dieppe, P., Cushnaghan, J., Tucker, M., Browning, S. and Shepstone, L. (2000) The Bristol “OA500 Study”: Progression and Impact of the Disease after 8 Years. Osteoarthritis and Cartilage, 8, 63-68. 
http://dx.doi.org/10.1053/joca.1999.0272</mixed-citation></ref><ref id="scirp.57283-ref46"><label>46</label><mixed-citation publication-type="other" xlink:type="simple">Krick, J.P., Sobal, J. and De Forge, B.R. (1986) Psychosocial Aspects of the Multidisciplinary Assessment of Osteoarthritis. Clinical Therapeutics, 9, 43-52.</mixed-citation></ref><ref id="scirp.57283-ref47"><label>47</label><mixed-citation publication-type="other" xlink:type="simple">Briggs, A., Scott, E. and Steele, K. (1999) Impact of Osteoarthritis and Analgesic Treatment on Quality of Life of an Elderly Population. Annals of Pharmacotherapy, 33, 1154-1159. http://dx.doi.org/10.1345/aph.18411</mixed-citation></ref><ref id="scirp.57283-ref48"><label>48</label><mixed-citation publication-type="other" xlink:type="simple">Lawrence, J.S. (1975) Hypertension in Relation to Musculoskeletal Disorders. Annals of the Rheumatic Diseases, 34, 451-456. http://dx.doi.org/10.1136/ard.34.5.451</mixed-citation></ref><ref id="scirp.57283-ref49"><label>49</label><mixed-citation publication-type="other" xlink:type="simple">Yelin, E., Lubeck, D., Holman, H. and Epstein, W. (1987) The Impact of Rheumatoid Arthritis and Osteoarthritis: The Activities of Patients with Rheumatoid Arthritis and Osteoarthritis Compared to Controls. Journal of Rheumatology, 14, 710-716.</mixed-citation></ref><ref id="scirp.57283-ref50"><label>50</label><mixed-citation publication-type="other" xlink:type="simple">Buckwalter, J.A., Martin, J. and Mankin, H.J. (2000) Synovial Joint Degeneration and the Syndrome of Osteoarthritis. Instructional Course Lectures, 49, 481-489.</mixed-citation></ref><ref id="scirp.57283-ref51"><label>51</label><mixed-citation publication-type="other" xlink:type="simple">Kuettner, K.E. (1992) Biochemistry of Articular Cartilage in Health and Disease. Clinical Biochemistry, 25, 155-163. 
http://dx.doi.org/10.1016/0009-9120(92)90224-G</mixed-citation></ref><ref id="scirp.57283-ref52"><label>52</label><mixed-citation publication-type="other" xlink:type="simple">Borghetti, P., Della Salda, L., De Angleis, E., Maltarello, M.C., Petronini, P.G., Cabassi, E., et al. (1995) Adaptive Cellular Response to Osmotic Stress in Pig Articular Chondrocytes. Tissue and Cell, 27, 173-183. 
http://dx.doi.org/10.1016/S0040-8166(95)80020-4</mixed-citation></ref><ref id="scirp.57283-ref53"><label>53</label><mixed-citation publication-type="other" xlink:type="simple">Brocklehurst, R., Bayliss, M.T., Maroudas, A., Coysh, H.L., Freeman, M.A., Revell, P.A. and Ali, S.Y. (1984) The Composition of Normal and Osteoarthritic Articular Cartilage from Human Knee Joints. With Special Reference to Unicompartmental Replacement and Osteotomy of the Knee. Journal of Bone and Joint Surgery, 66, 95-106.</mixed-citation></ref><ref id="scirp.57283-ref54"><label>54</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Marks</surname><given-names> R. </given-names></name>,<etal>et al</etal>. (<year>1991</year>)<article-title>Effect of Altered Functional Demand on the Structure and Functional Properties of Articular Cartilage</article-title><source> New Zealand Journal Physiotherapy</source><volume> 19</volume>,<fpage> 31</fpage>-<lpage>34</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref55"><label>55</label><mixed-citation publication-type="other" xlink:type="simple">Jones, G.M. and Watt, D.G.D. (1971) Muscular Control of Landing from Unexpected Falls in Man. Journal of Physiology, 219, 729-737. http://dx.doi.org/10.1113/jphysiol.1971.sp009685</mixed-citation></ref><ref id="scirp.57283-ref56"><label>56</label><mixed-citation publication-type="other" xlink:type="simple">Kim, K.K.T., Shahid, M. and Sharif, M. (1996) Recent Advances in Osteoarthritis. Singapore Medical Journal, 37, 189-193.</mixed-citation></ref><ref id="scirp.57283-ref57"><label>57</label><mixed-citation publication-type="other" xlink:type="simple">Cvijetiae, S., Campbell, L., Cooper, C., Kirwan, J. and Potocki, K. (2000) Radiographic Osteoarthritis in the Elderly Population of Zagreb: Distribution, Correlates, and the Pattern of Joint Involvement. Clinical Science, 41, 58-63.</mixed-citation></ref><ref id="scirp.57283-ref58"><label>58</label><mixed-citation publication-type="other" xlink:type="simple">McAlindon, T.E. (1999) The Knee. Ballieres Clinical Rheumatology, 13, 329-344. 
http://dx.doi.org/10.1053/berh.1999.0023</mixed-citation></ref><ref id="scirp.57283-ref59"><label>59</label><mixed-citation publication-type="other" xlink:type="simple">Bland, J.H. (1983) The Reversibility of Osteoarthritis: A Review. American Journal of Medicine, 74, 16-26. 
http://dx.doi.org/10.1016/0002-9343(83)90524-7</mixed-citation></ref><ref id="scirp.57283-ref60"><label>60</label><mixed-citation publication-type="other" xlink:type="simple">Treadwell, B.V. and Mankin, H.J. (1986) The Synthetic Processes of Articular Cartilage. Clinical Orthopaedic and Related Research, 213, 50-61. http://dx.doi.org/10.1097/00003086-198612000-00007</mixed-citation></ref><ref id="scirp.57283-ref61"><label>61</label><mixed-citation publication-type="other" xlink:type="simple">Brooks, P.M. and Marsh, L.M. (1995) New Insights into Osteoarthritis. Medical Journal of Australia, 63, 367-369.</mixed-citation></ref><ref id="scirp.57283-ref62"><label>62</label><mixed-citation publication-type="book" xlink:type="simple">Gerber, L.H. and Hicks, J.E. (1992) Rehabilitation in the Management of Patients with Osteoarthritis. In: Goldberg, V.M., Mankin, H.J., Moskowitz, R.W. and Howell, D.S., Eds., Osteoarthritis, Diagnosis and Medical/Surgical Management, 2nd Edition, W.B. Saunders Company, Philadelphia, 433.</mixed-citation></ref><ref id="scirp.57283-ref63"><label>63</label><mixed-citation publication-type="other" xlink:type="simple">Gelber, A.C., Hochberg, M.C., Mead, L.A., Wang, N.Y., Wigley, F.M. and Klag, M.J. (2000) Joint Injury in Young Adults and Risk for Subsequent Knee and Hip Osteoarthritis. Annals of Internal Medicine, 133, 321-328. 
http://dx.doi.org/10.7326/0003-4819-133-5-200009050-00007</mixed-citation></ref><ref id="scirp.57283-ref64"><label>64</label><mixed-citation publication-type="other" xlink:type="simple">Perry, G.H., Smith, M.J.P. and Whiteside, C.G. (1972) Spontaneous Recovery of the Joint Space in Degenerative Hip Disease. Annals of the Rheumatic Diseases, 31, 440-448. http://dx.doi.org/10.1136/ard.31.6.440</mixed-citation></ref><ref id="scirp.57283-ref65"><label>65</label><mixed-citation publication-type="other" xlink:type="simple">Liang, M.H. and Jette, A.M. (1981) Measuring Functional Ability in Chronic Arthritis. Arthritis and Rheumatism, 24, 80-86. http://dx.doi.org/10.1002/art.1780240113</mixed-citation></ref><ref id="scirp.57283-ref66"><label>66</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Moritz</surname><given-names> U. </given-names></name>,<etal>et al</etal>. (<year>1980</year>)<article-title>Physical Therapy and Rehabilitation</article-title><source> Scandanavian Journal of Rheumatology</source><volume> 43</volume>,<fpage> 49</fpage>-<lpage>55</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref67"><label>67</label><mixed-citation publication-type="other" xlink:type="simple">Juhn, M.S. (2000) Manual Physical Therapy and Exercise Helpful for Knee Osteoarthritis. Physician and Sports Medicine, 28, 24.</mixed-citation></ref><ref id="scirp.57283-ref68"><label>68</label><mixed-citation publication-type="other" xlink:type="simple">Berman, B.M., Swyers, J.P. and Ezzo, J. (2000) The Evidence for Acupuncture as a Treatment for Rheumatological Conditions. Rheumatic Disease Clinics of North America, 26, 103-115. 
http://dx.doi.org/10.1016/S0889-857X(05)70124-1</mixed-citation></ref><ref id="scirp.57283-ref69"><label>69</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R. and De Palma, F. (1999) Effect of Laser Therapy in Osteoarthritis. Research Physiotherapy International, 4, 141-157. http://dx.doi.org/10.1002/pri.159</mixed-citation></ref><ref id="scirp.57283-ref70"><label>70</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R., Ghassemi, M., Duarte, R. and Van Nguyen, J.P. (1999) A Review of the Literature on Shortwave Diathermy as Applied to Osteo-Arthritis of the Knee. Physiotherapy, 85, 304-316. 
http://dx.doi.org/10.1016/S0031-9406(05)67134-9</mixed-citation></ref><ref id="scirp.57283-ref71"><label>71</label><mixed-citation publication-type="other" xlink:type="simple">Marks, R., Ghanagarajah, S. and Ghassemi, M. (2000) Ultrasound for Treating Arthritis. A Systematic Review. Physio- therapy, 86, 452-463. http://dx.doi.org/10.1016/S0031-9406(05)60807-3</mixed-citation></ref><ref id="scirp.57283-ref72"><label>72</label><mixed-citation publication-type="other" xlink:type="simple">Stelian, J., Gil, I., Habot, B., Rosenthal, M., Abramovici, I., Kutok, N. and Khahil, A. (1992) Improvement of Pain and Disability in Elderly Patients with Degenerative Osteoarthritis of the Knee Treated with Narrow-Band Light Therapy. Journal of the American Geriatric Society, 40, 23-26. http://dx.doi.org/10.1111/j.1532-5415.1992.tb01824.x</mixed-citation></ref><ref id="scirp.57283-ref73"><label>73</label><mixed-citation publication-type="other" xlink:type="simple">Favaro, L., Frisoni, M., Baffoni, L. and Ferri, E.S. (1994) Successful Treatment of Hand Erosive Osteoarthritis by Infrared Radiation. Europa Medicophysica, 30, 45-48.</mixed-citation></ref><ref id="scirp.57283-ref74"><label>74</label><mixed-citation publication-type="other" xlink:type="simple">Trock, D.H., Bollet, A.J., Dyer, R.H., Fielding, L.P., Miner, W.K. and Markoll, R. (1993) A Double-Blind Trial of the Clinical Effects of Pulsed Electromagnetic Fields in Osteoarthritis. Journal of Rheumatology, 20, 456-460.</mixed-citation></ref><ref id="scirp.57283-ref75"><label>75</label><mixed-citation publication-type="other" xlink:type="simple">Loudon, J.K. (1999) Case Report: Manual Therapy Management of Hip Osteoarthritis. Journal of Manual &amp; Manipulative Therapy, 7, 203-208. http://dx.doi.org/10.1179/106698199790811528</mixed-citation></ref><ref id="scirp.57283-ref76"><label>76</label><mixed-citation publication-type="other" xlink:type="simple">Oosterveld, F.G. and Rasker, J.J. (1994) Effects of Local Heat and Cold Treatment on Surface and Articular Temperature of Arthritic Knees. Arthritis and Rheumatism, 37, 1578-1582. http://dx.doi.org/10.1002/art.1780371104</mixed-citation></ref><ref id="scirp.57283-ref77"><label>77</label><mixed-citation publication-type="other" xlink:type="simple">Brosseau, L., Welch, V., Wells, G., Tugwell, P., de Bie, R., Gam, A., et al. (2000) Low Level Laser Therapy for Osteoarthritis and Rheumatoid Arthritis: A Meta-Analysis. Journal of Rheumatology, 27, 1961-1969.</mixed-citation></ref><ref id="scirp.57283-ref78"><label>78</label><mixed-citation publication-type="other" xlink:type="simple">Gordon, A., Merenstein, J.H., D’Amico, F. and Hudgens, D. (1998) The Effects of Therapeutic Touch on Patients with Osteoarthritis of the Knee. Journal of Family Practice, 47, 271-277.</mixed-citation></ref><ref id="scirp.57283-ref79"><label>79</label><mixed-citation publication-type="other" xlink:type="simple">Robertsson, O., Wingstrand, H. and &amp;Ouml;nnerf&amp;auml;lt, R. (1995) Intracapsular Pressure and Pain in Coxarthrosis. Journal of Arthroplasty, 10, 632-635. http://dx.doi.org/10.1016/S0883-5403(05)80207-4</mixed-citation></ref><ref id="scirp.57283-ref80"><label>80</label><mixed-citation publication-type="other" xlink:type="simple">Hochberg, M.C., Altman, R.D., Brandt, K.D., Clark, B.M., Dieppe, P.A., Griffin, M.R., et al. (1995) Guidelines for the Medical Management of Osteoarthritis Part I. Osteoarthritis of the Hip. Arthritis and Rheumatism, 38, 1535-1540. 
http://dx.doi.org/10.1002/art.1780381103</mixed-citation></ref><ref id="scirp.57283-ref81"><label>81</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>O’ Connel</surname><given-names> P. </given-names></name>,<etal>et al</etal>. (<year>1994</year>)<article-title>Conservative Management of Osteoarthritis of the Hip</article-title><source> Irish Medical Journal</source><volume> 87</volume>,<fpage> 170</fpage>-<lpage>174</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref82"><label>82</label><mixed-citation publication-type="other" xlink:type="simple">Bunning, R.D. and Materson, R.S. (1991) A Rational Program of Exercise for Patients with Osteoarthritis. Seminars in Arthritis and Rheumatism, 21, 33-43. http://dx.doi.org/10.1016/0049-0172(91)90038-2</mixed-citation></ref><ref id="scirp.57283-ref83"><label>83</label><mixed-citation publication-type="other" xlink:type="simple">Steultjens, M.P.M., Dekker, J., van Baar, M.E., Oostendorp, R.A.B. and Bijlsma, J.W.J. (2000) Range of Motion and Disability in Patients with Osteoarthritis of the Knee or Hip. Rheumatology, 39, 955-961. 
http://dx.doi.org/10.1093/rheumatology/39.9.955</mixed-citation></ref><ref id="scirp.57283-ref84"><label>84</label><mixed-citation publication-type="other" xlink:type="simple">Waters, R.L., Perry, J., Conaty, P., Lunsford, B. and O’Meara, P. (1987) The Energy Cost of Walking with Arthritis of the Hip and Knee. Clinical Orthopaedics and Related Research, 214, 278-284.</mixed-citation></ref><ref id="scirp.57283-ref85"><label>85</label><mixed-citation publication-type="other" xlink:type="simple">Sirca, A. and Susec-Michieli, M. (1980) Selective Type II Fibre Muscle Atrophy in Patients with Osteoarthritis of the Hip. Journal of the Neurological Sciences, 44, 149-159. http://dx.doi.org/10.1016/0022-510X(80)90123-9</mixed-citation></ref><ref id="scirp.57283-ref86"><label>86</label><mixed-citation publication-type="other" xlink:type="simple">Nakamura, T. and Suzuki, K. (1992) Muscular Changes in Osteoarthritis of the Hip and Knee. Journal of the Japanese Orthopaedic Association, 66, 467-475.</mixed-citation></ref><ref id="scirp.57283-ref87"><label>87</label><mixed-citation publication-type="other" xlink:type="simple">Burkhard, A. and Taillard, W. (1975) Electromyographische untersuching der statischen und dynamischen funktion der hufte nach total endoprothese. Zeitschruft fur Orthopedicshe, 113, 322-331.</mixed-citation></ref><ref id="scirp.57283-ref88"><label>88</label><mixed-citation publication-type="other" xlink:type="simple">Dieppe, P. (1995) Management of Hip Osteoarthritis. British Medical Journal, 311, 853-857. 
http://dx.doi.org/10.1136/bmj.311.7009.853</mixed-citation></ref><ref id="scirp.57283-ref89"><label>89</label><mixed-citation publication-type="other" xlink:type="simple">Lunghi, M.E., Miller, P.M.C. and McQuillan, W.M. (1978) Pyscho-Social Factors in Osteoarthritis of the Hip. Journal of Psychosomatic Research, 22, 57-63. http://dx.doi.org/10.1016/0022-3999(78)90091-0</mixed-citation></ref><ref id="scirp.57283-ref90"><label>90</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Hawley</surname><given-names> D.J. </given-names></name>,<etal>et al</etal>. (<year>1995</year>)<article-title>Psycho-Educational Interventions in the Treatment of Arthritis</article-title><source> Clinical Rheumatology</source><volume> 9</volume>,<fpage> 803</fpage>-<lpage> 823</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref91"><label>91</label><mixed-citation publication-type="other" xlink:type="simple">Allegrante, J.P. (1996) The Role of Adjunctive Therapy in the Management of Chronic Nonmalignant Pain. American Journal of Medicine, 101, S33- S39. http://dx.doi.org/10.1016/S0002-9343(96)00136-2</mixed-citation></ref><ref id="scirp.57283-ref92"><label>92</label><mixed-citation publication-type="other" xlink:type="simple">Bradley, L.A. and Alberts, K.R. (1999) Psychological and Behavioral Approaches to Pain Management for Patients with Rheumatic Disease. Rheumatic Disease Clinics of North America, 25, 215-232. 
http://dx.doi.org/10.1016/S0889-857X(05)70061-2</mixed-citation></ref><ref id="scirp.57283-ref93"><label>93</label><mixed-citation publication-type="other" xlink:type="simple">Lorig, K., Lubeck, D., Kraines, R.G., Seleznick, M. and Holman, H.R. (1985) Outcomes of Self-Help Education for Patients with Arthritis. Arthritis and Rheumatism, 28, 680-685. http://dx.doi.org/10.1002/art.1780280612</mixed-citation></ref><ref id="scirp.57283-ref94"><label>94</label><mixed-citation publication-type="other" xlink:type="simple">Lorig, K. and Holman, H. (1993) Arthritis Self-Management Studies: A Twelve-Year Review. Health Education Quarterly, 20, 17-28. http://dx.doi.org/10.1177/109019819302000104</mixed-citation></ref><ref id="scirp.57283-ref95"><label>95</label><mixed-citation publication-type="other" xlink:type="simple">Lorig, K.R., Mazonson, P.D. and Holman, H.R. (1993) Evidence Suggesting That Health Education for Self-Management in Patients with Chronic Arthritis Has Sustained Health Benefits While Reducing Care Costs. Arthritis and Rheumatism, 36, 439-446. http://dx.doi.org/10.1002/art.1780360403</mixed-citation></ref><ref id="scirp.57283-ref96"><label>96</label><mixed-citation publication-type="other" xlink:type="simple">Perrot, S. and Menkes, C.-J. (1996) Nonpharmacological Approaches to Pain in Osteoarthritis. Drugs, 52, 21-26. 
http://dx.doi.org/10.2165/00003495-199600523-00005</mixed-citation></ref><ref id="scirp.57283-ref97"><label>97</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Ruoff</surname><given-names> G.E. </given-names></name>,<etal>et al</etal>. (<year>1999</year>)<article-title>Strategies to Control Chronic Musculoskeletal Pain: Part 1, Work-Up and Nondrug Therapy</article-title><source> Consultant</source><volume> 39</volume>,<fpage> 2561</fpage>-<lpage>2571</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref98"><label>98</label><mixed-citation publication-type="other" xlink:type="simple">Stitik, T.P., Nadler, S.F., Foye, P.M., et al. (1999) Osteoarthritis of the Hip and Knee: Practical Nondrug Steps to Successful Therapy. Consultant, 39, 1707-1714.</mixed-citation></ref><ref id="scirp.57283-ref99"><label>99</label><mixed-citation publication-type="other" xlink:type="simple">Lane, N.E. and Thompson, J.M. (1997) Management of Osteoarthritis in the Primary-Care Setting: An Evidence-Based Approach. American Journal of Medicine, 13, S25- S30. http://dx.doi.org/10.1016/S0002-9343(97)90005-X</mixed-citation></ref><ref id="scirp.57283-ref100"><label>100</label><mixed-citation publication-type="other" xlink:type="simple">Puppione, A.A. and Schumann, L. (1999) Management Strategies for Older Adults with Osteoarthritis: How to Promote and Maintain Function. Journal of the American Academy of Nurse Practitioners, 11, 167-174. 
http://dx.doi.org/10.1111/j.1745-7599.1999.tb00558.x</mixed-citation></ref><ref id="scirp.57283-ref101"><label>101</label><mixed-citation publication-type="other" xlink:type="simple">Superio-Cabuslay, E., Ward, M.M. and Lorig, K.R. (1996) Patient Education Interventions in Osteoarthritis and Rheumatoid Arthritis: A Meta-Analytic Comparison with Nonsteroidal Antiinflammatory Drug Treatment. Arthritis Care &amp; Research, 9, 292-301. 
http://dx.doi.org/10.1002/1529-0131(199608)9:4&lt;292::AID-ANR1790090414&gt;3.0.CO;2-4</mixed-citation></ref><ref id="scirp.57283-ref102"><label>102</label><mixed-citation publication-type="other" xlink:type="simple">Bagge, E. and Brooks, P. (1995) Osteoarthritis in Older Patients. Drugs and Aging, 7, 176-183. 
http://dx.doi.org/10.2165/00002512-199507030-00003</mixed-citation></ref><ref id="scirp.57283-ref103"><label>103</label><mixed-citation publication-type="other" xlink:type="simple">Mazzuca, S.A., Brandt, K.D., Katz, B.P., Hanna, M.P. and Melfi, C.A. (1999) Reduced Utilization and Cost of Primary Care Clinic Visits Resulting from Self-Care Education for Patients with Osteoarthritis of the Knee. Arthritis and Rheumatism, 42, 1267-1273. http://dx.doi.org/10.1002/1529-0131(199906)42:6&lt;1267::AID-ANR25&gt;3.0.CO;2-E</mixed-citation></ref><ref id="scirp.57283-ref104"><label>104</label><mixed-citation publication-type="other" xlink:type="simple">Ronen, R., Braun, Z., Eyal, P. and Eldar, R. (1996) A Community-Oriented Programme for Rehabilitation of Persons with Arthritis. Disability and Rehabilitation, 18, 476-481. http://dx.doi.org/10.3109/09638289609165912</mixed-citation></ref><ref id="scirp.57283-ref105"><label>105</label><mixed-citation publication-type="other" xlink:type="simple">Skou, S.T., Simonsen, M.E., Odgaard, A., Roos, E.M. (2014) Predictors of Long-Term Effect from Education and Exercise in Patients with Knee and Hip Pain. Danish Medical Journal, 61, Article ID: A4867.</mixed-citation></ref><ref id="scirp.57283-ref106"><label>106</label><mixed-citation publication-type="other" xlink:type="simple">Wade, J. and Liang, M.H. (1988) Management of Non-Inflammatory Musculoskeletal Disorders in the Elderly. Complementary Therapy, 14, 38-43.</mixed-citation></ref><ref id="scirp.57283-ref107"><label>107</label><mixed-citation publication-type="other" xlink:type="simple">Mazzuca, S.A. (1982) Does Patient Education in Chronic Disease Have Therapeutic Value? Journal of Chronic Diseases, 35, 521-529. http://dx.doi.org/10.1016/0021-9681(82)90071-6</mixed-citation></ref><ref id="scirp.57283-ref108"><label>108</label><mixed-citation publication-type="other" xlink:type="simple">Bull, F.C., Kreuter, M.W. and Scharff, D.P. (1999) Effects of Tailored, Personalized and General Health Messages on Physical Activity. Patient Education and Counseling, 36, 181-192. http://dx.doi.org/10.1016/S0738-3991(98)00134-7</mixed-citation></ref><ref id="scirp.57283-ref109"><label>109</label><mixed-citation publication-type="other" xlink:type="simple">Kreuter, M.W., Bull, F.C., Clark, E.M. and Oswald, D.L. (1999) Understanding How People Process Health Information: A Comparison of Tailored and Nontailored Weight-Loss Materials. Health Psychology, 18, 487-494. 
http://dx.doi.org/10.1037/0278-6133.18.5.487</mixed-citation></ref><ref id="scirp.57283-ref110"><label>110</label><mixed-citation publication-type="other" xlink:type="simple">Allegrante, J.P., Kovar, P.A., MacKenzie, C.R., Peterson, M.G.E. and Gutin, B. (1993) A Walking Education Program for Patients with Osteoarthritis of the Knee: Theory and Intervention Strategies. Health Education Quarterly, 20, 63-81. 
http://dx.doi.org/10.1177/109019819302000107</mixed-citation></ref><ref id="scirp.57283-ref111"><label>111</label><mixed-citation publication-type="other" xlink:type="simple">Gecht, M.R., Connell, K.J., Sinacore, J.M. and Prohaska, T.R. (1996) A Survey of Exercise Beliefs and Exercise Habits among People with Arthritis. Arthritis Care and Research, 9, 82-88. 
http://dx.doi.org/10.1002/1529-0131(199604)9:2&lt;82::AID-ANR1790090203&gt;3.0.CO;2-T</mixed-citation></ref><ref id="scirp.57283-ref112"><label>112</label><mixed-citation publication-type="other" xlink:type="simple">Hirano, P.C., Laurent, D.D. and Lorig, K. (1994) Arthritis Patient-Education Studies, 1987-1991: A Review of the Literature. Patient Education and Counselling, 24, 9-54. http://dx.doi.org/10.1016/0738-3991(94)90024-8</mixed-citation></ref><ref id="scirp.57283-ref113"><label>113</label><mixed-citation publication-type="other" xlink:type="simple">Sullivan, T., Allegrante, J.P., Peterson, M.G.E., Kovar, P.A. and MacKenzie, C.R. (1998) One-Year Follow up of Patients with Osteoarthritis of the Knee Who Participated in a Program of Supervised Fitness Walking and Supportive Patient Education. Arthritis Care and Research, 11, 228-233. http://dx.doi.org/10.1002/art.1790110403</mixed-citation></ref><ref id="scirp.57283-ref114"><label>114</label><mixed-citation publication-type="other" xlink:type="simple">Barlow, J.H., Williams, B. and Wright, C.C. (1999) Instilling the Strength to Fight the Pain and Get on with Life: Learning to Become an Arthritis Self-Manager through an Adult Education Programme. Health Education Research, 14, 533-544. http://dx.doi.org/10.1093/her/14.4.533</mixed-citation></ref><ref id="scirp.57283-ref115"><label>115</label><mixed-citation publication-type="other" xlink:type="simple">Hopman-Rock, M. and Westhoff, M.H. (2000) The Effects of a Health Educational and Exercise Program for Older Adults with Osteoarthritis for the Hip or Knee. Journal of Rheumatology, 27, 1947-1954.</mixed-citation></ref><ref id="scirp.57283-ref116"><label>116</label><mixed-citation publication-type="other" xlink:type="simple">Banwell, B.F. (1989) Exercise and Arthritis. Postgraduate Advances in Arthritis for Health Professionals, I-V, 3-12.</mixed-citation></ref><ref id="scirp.57283-ref117"><label>117</label><mixed-citation publication-type="other" xlink:type="simple">Neville, C., Fortin, P.R., Fitzcharles, M.-A., Baron, M., Abrahamowitz, M., Du Berger, R. and Esdaile, J.M. (1999) The Needs of Patients with Arthritis: The Patient’s Perspective. Arthritis &amp; Rheumatism, 12, 85-95. 
http://dx.doi.org/10.1002/1529-0131(199904)12:2&lt;85::AID-ART3&gt;3.0.CO;2-W</mixed-citation></ref><ref id="scirp.57283-ref118"><label>118</label><mixed-citation publication-type="other" xlink:type="simple">Altman, D., Hochberg, M.C., Moskowitz, R.W., et al. (2000) Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee: 2000 Update. Arthritis and Rheumatism, 43, 1905-1915. 
http://dx.doi.org/10.1002/1529-0131(200009)43:9&lt;1905::AID-ANR1&gt;3.0.CO;2-P</mixed-citation></ref><ref id="scirp.57283-ref119"><label>119</label><mixed-citation publication-type="other" xlink:type="simple">Kreuter, M.W., Strecher, V.J. and Glassman, B. (1999) One Size Does Not Fit All: The Case for Tailoring Print Materials. Annals of Behavioral Medicine, 21, 276-283. http://dx.doi.org/10.1007/BF02895958</mixed-citation></ref><ref id="scirp.57283-ref120"><label>120</label><mixed-citation publication-type="other" xlink:type="simple">Dexter, P.A. (1991) Joint Exercises in Elderly Persons with Symptomatic Osteoarthritis of the Hip or Knee. Performance Patterns, Medical Support Patterns, and the Relationship between Exercising and Medical Care. Arthritis Care and Research, 5, 36-41. http://dx.doi.org/10.1002/art.1790050109</mixed-citation></ref><ref id="scirp.57283-ref121"><label>121</label><mixed-citation publication-type="other" xlink:type="simple">Weinberger, M., Tierney, W.M., Cowper, P.A., Katz, B.P. and Booher, P.A. (1993) Cost-Effectiveness of Increased Telephone Contact for Patients with Osteoarthritis. A Randomized Controlled Trial. Arthritis and Rheumatism, 36, 243-246. http://dx.doi.org/10.1002/art.1780360216</mixed-citation></ref><ref id="scirp.57283-ref122"><label>122</label><mixed-citation publication-type="other" xlink:type="simple">Rene, J., Weinberger, M., Mazzuca, S.A., Brandt, K.D. and Katz, B.P. (1992) Reduction of Joint Pain in Patients with Knee Osteoarthritis Who Have Received Monthly Telephone Calls from Lay Personnel and Whose Medical Treatment Regimens Have Remained Stable. Arthritis and Rheumatism, 35, 511-555. http://dx.doi.org/10.1002/art.1780350504</mixed-citation></ref><ref id="scirp.57283-ref123"><label>123</label><mixed-citation publication-type="other" xlink:type="simple">Masiak, R., Austin, J. and Heck, L. (1996) Health Outcomes of Two Telephone Interventions for Patients with Rheumatoid Arthritis or Osteoarthritis. Arthritis and Rheumatism, 39, 1391-1399. http://dx.doi.org/10.1002/art.1780390818</mixed-citation></ref><ref id="scirp.57283-ref124"><label>124</label><mixed-citation publication-type="other" xlink:type="simple">Calfas, K.J., Kaplan, R.M. and Ingram, R.E. (1992) One-Year Evaluation of Cognitive-Behavioral Intervention in Osteoarthritis. Arthritis Care and Research, 5, 202-209. http://dx.doi.org/10.1002/art.1790050404</mixed-citation></ref><ref id="scirp.57283-ref125"><label>125</label><mixed-citation publication-type="other" xlink:type="simple">Castaneda, D.M., Bigatti, S. and Cronan, T.A. (1998) Gender and Exercise Behavior among Women and Men with Osteoarthritis. Women &amp; Health, 27, 33-53. http://dx.doi.org/10.1300/J013v27n04_03</mixed-citation></ref><ref id="scirp.57283-ref126"><label>126</label><mixed-citation publication-type="other" xlink:type="simple">Keefe, F.J., Lefebvre, J.C., Kerns, R.D., Rosenberg, R., Beaupre, P., Prochaska, J., et al. (2000) Understanding the Adoption of Arthritis Self-Management: Stages of Change Profiles among Arthritis Patients. Pain, 87, 303-313. 
http://dx.doi.org/10.1016/S0304-3959(00)00294-3</mixed-citation></ref><ref id="scirp.57283-ref127"><label>127</label><mixed-citation publication-type="other" xlink:type="simple">Keefe, F.J., Caldwell, D.S., Baucom, D., Salley, A., Robinson, E., Timmons, K., et al. (1999) Spouse-Assisted Coping Skills Training in the Management of Knee Pain in Osteoarthritis: Long-Term Follow-Up Results. Arthritis &amp; Rheumatism, 12, 101-111. http://dx.doi.org/10.1002/1529-0131(199904)12:2&lt;101::AID-ART5&gt;3.0.CO;2-9</mixed-citation></ref><ref id="scirp.57283-ref128"><label>128</label><mixed-citation publication-type="other" xlink:type="simple">Hampson, S.E., Glasgow, R.E. and Zeiss, A.M. (1996) Coping with Osteoarthritis by Older Adults. Arthritis Care and Research, 9, 133-141. http://dx.doi.org/10.1002/1529-0131(199604)9:2&lt;133::AID-ANR1790090210&gt;3.0.CO;2-9</mixed-citation></ref><ref id="scirp.57283-ref129"><label>129</label><mixed-citation publication-type="other" xlink:type="simple">Rice, J.M. (1989) Decreasing Osteoarthritis Pain. A Psychological Case Report with Follow-Up Data. Clinical Journal of Pain, 5, 183-188. http://dx.doi.org/10.1097/00002508-198906000-00009</mixed-citation></ref><ref id="scirp.57283-ref130"><label>130</label><mixed-citation publication-type="other" xlink:type="simple">Hirokawa, S. and Matsumura, K. (1989) Biofeedback Gait Training System for Temporal and Distance Factors. Medical Biological Engineering and Computing, 27, 8-13. http://dx.doi.org/10.1007/BF02442163</mixed-citation></ref><ref id="scirp.57283-ref131"><label>131</label><mixed-citation publication-type="other" xlink:type="simple">Keefe, F.J., Caldwell, D.S., Williams, D.A., Gil, K.M., Mitchell, D., Robertson, C., et al. (1990) Pain Coping Skills in the Management of Osteoarthritic Knee Pain-II: Follow-Up Results. Behavior Therapy, 21, 435-447. 
http://dx.doi.org/10.1016/S0005-7894(05)80357-0</mixed-citation></ref><ref id="scirp.57283-ref132"><label>132</label><mixed-citation publication-type="other" xlink:type="simple">Zischke, J.K. (1987) Research Evidence for the Effectiveness of a Recreational Exercise Program for People with Arthritis. Proceedings of the Arthritis Health Professional Association Annual Meeting, Philadelphia.</mixed-citation></ref><ref id="scirp.57283-ref133"><label>133</label><mixed-citation publication-type="other" xlink:type="simple">Simpson, C.F. and Dickenson, G.R. (1983) Exercise. American Journal of Nursing, 2, 273-274.</mixed-citation></ref><ref id="scirp.57283-ref134"><label>134</label><mixed-citation publication-type="other" xlink:type="simple">Summers, M.N., Haley, W.E., Reveille, J.D. and AlarcOan, G.S. (1988) Radiographic Assessment and Psychological Variables as Predictors of Pain and Functional Impairment in Osteoarthritis of the Knee or Hip. Arthritis and Rheumatism, 31, 204- 209. http://dx.doi.org/10.1002/art.1780310208</mixed-citation></ref><ref id="scirp.57283-ref135"><label>135</label><mixed-citation publication-type="other" xlink:type="simple">Fuchs, H.A. (1987) Saturday Conference: Management of Osteoarthritis. Southern Medical Journal, 80, 618-622. 
http://dx.doi.org/10.1097/00007611-198705000-00017</mixed-citation></ref><ref id="scirp.57283-ref136"><label>136</label><mixed-citation publication-type="other" xlink:type="simple">Hampson, S.E., Glasgow, R.E., Zeiss, A.M., Birskovich, S.F., Foster, L. and Lines, A. (1993) Self-Management of Osteoarthritis. Arthritis Care and Research, 6, 17-22. http://dx.doi.org/10.1002/art.1790060105</mixed-citation></ref><ref id="scirp.57283-ref137"><label>137</label><mixed-citation publication-type="other" xlink:type="simple">Palmoski, M., Perricine, E. and Brandt, K.D. (1979) Development and Reversal of Proteoglycan Aggregation Defect in Normal Canine Knee Articular Cartilage after Immobilisation. Arthritis and Rheumatism, 22, 508-517. 
http://dx.doi.org/10.1002/art.1780220511</mixed-citation></ref><ref id="scirp.57283-ref138"><label>138</label><mixed-citation publication-type="other" xlink:type="simple">Block, J.A. and Schnitzer, T.J. (1997) Therapeutic Approaches to Osteoarthritis. Hospital Practice, 15, 159-164.</mixed-citation></ref><ref id="scirp.57283-ref139"><label>139</label><mixed-citation publication-type="other" xlink:type="simple">Ohsawa, S. and Ueno, R. (1997) Heel Lifting as a Conservative Therapy for Osteoarthritis of the Hip: Based on the Rationale of Pauwels’ Intertrochanteric Osteotomy. Prosthetics and Orthotics International, 21, 153-158.</mixed-citation></ref><ref id="scirp.57283-ref140"><label>140</label><mixed-citation publication-type="other" xlink:type="simple">Brandt, K.D. (1998) The Importance of Nonpharmacologic Approaches in the Management of Osteoarthritis. American Journal of Medicine, 105, 39S-44S. http://dx.doi.org/10.1016/S0002-9343(98)00075-8</mixed-citation></ref><ref id="scirp.57283-ref141"><label>141</label><mixed-citation publication-type="other" xlink:type="simple">Jackson, S.J., Krebs, D.E. and Harris, B.A. (1997) Acetabular Pressures during Hip Arthritis Exercises. Arthritis Care and Research, 10, 308-319. http://dx.doi.org/10.1002/art.1790100505</mixed-citation></ref><ref id="scirp.57283-ref142"><label>142</label><mixed-citation publication-type="other" xlink:type="simple">Kettunen, J.A., Kujala, U.M., Raty, H., Videman, T., Sarna, S., Impivaara, O. and Koskinen, S. (2000) Factors Associated with Hip Joint Rotation in Former Athletes. British Journal of Sports Medicine, 34, 44-48. 
http://dx.doi.org/10.1136/bjsm.34.1.44</mixed-citation></ref><ref id="scirp.57283-ref143"><label>143</label><mixed-citation publication-type="other" xlink:type="simple">Syed, I.Y. and Davis, B.L. (2000) Obesity and Osteoarthritis of the Knee: Hypotheses Concerning the Relationship between Ground Reaction Forces and Quadriceps Fatigue in Long-Duration Walking. Medical Hypotheses, 54, 182-185. http://dx.doi.org/10.1054/mehy.1999.0013</mixed-citation></ref><ref id="scirp.57283-ref144"><label>144</label><mixed-citation publication-type="other" xlink:type="simple">Sharma, L., Lou, C., Cahue, S. and Dunlop, D.D. (2000) The Mechanisms of the Effect of Obesity in Knee Osteoarthritis. Arthritis and Rheumatism, 43, 568-575. 
http://dx.doi.org/10.1002/1529-0131(200003)43:3&lt;568::AID-ANR13&gt;3.0.CO;2-E</mixed-citation></ref><ref id="scirp.57283-ref145"><label>145</label><mixed-citation publication-type="other" xlink:type="simple">Foye, P.M., Stitik, T.P., Chen, B.Q. and Nadler, S.F. (2000) Osteoarthritis and Body Weight. Nutrition Research, 20, 899-903. http://dx.doi.org/10.1016/S0271-5317(00)00164-0</mixed-citation></ref><ref id="scirp.57283-ref146"><label>146</label><mixed-citation publication-type="other" xlink:type="simple">Kealy, R.D., Lawler, D.F., Ballam, J.M., Lust, G., Smith, G.K., Biery, D.N. and Olsson, S.E. (1997) Five-Year Longitudinal Study on Limited Food Consumption and Development of Osteoarthritis in Coxofemoral Joints of Dogs. Journal of the American Veterinary Medical Association, 210, 222-225.</mixed-citation></ref><ref id="scirp.57283-ref147"><label>147</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Petrella</surname><given-names> R.J. </given-names></name>,<etal>et al</etal>. (<year>1999</year>)<article-title>Exercises for Patients with Knee Osteoarthritis</article-title><source> Physician and Sportsmedicine</source><volume> 27</volume>,<fpage> 109</fpage>-<lpage>111</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref148"><label>148</label><mixed-citation publication-type="other" xlink:type="simple">Simkin, P.A., de Lateur, B.J., Alquist, A.D., Questad, K.A., Beardsley, R.M. and Esselman, P.C. (1999) Continuous Passive Motion for Osteoarthritis of the Hip: A Pilot Study. Journal of Rheumatology, 26, 1987-1991.</mixed-citation></ref><ref id="scirp.57283-ref149"><label>149</label><mixed-citation publication-type="other" xlink:type="simple">Imamura, S.T., Riberto, M., Fischer, A.A., Imamura, M., Kaziyama, H.H.S. and Teixeira, M.J. (1998) Successful Pain Relief by Treatment of Myofascial Components in Patients with Hip Pathology Scheduled for Total Hip Replacement. Journal of Musculoskeletal Pain, 6, 73-89. http://dx.doi.org/10.1300/J094v06n01_06</mixed-citation></ref><ref id="scirp.57283-ref150"><label>150</label><mixed-citation publication-type="other" xlink:type="simple">van Baar, M.E., Dekker, J., Lemmens, J.A., Oostendorp, R.A. and Bijlsma, J.W. (1998) Pain and Disability in Patients with Osteoarthritis of Hip or Knee: The Relationship with Articular, Kinesiological, and Psychological Characteristics. Journal of Rheumatology, 25, 125-133.</mixed-citation></ref><ref id="scirp.57283-ref151"><label>151</label><mixed-citation publication-type="other" xlink:type="simple">Sylvester, K.L. (1989) Investigation of the Effect of Hydrotherapy in the Treatment of Osteoarthritic Hips. Clinical Rehabilitation, 4, 223-228. http://dx.doi.org/10.1177/026921559000400307</mixed-citation></ref><ref id="scirp.57283-ref152"><label>152</label><mixed-citation publication-type="other" xlink:type="simple">Suomi, R. and Koceja, D.M. (2000) Postural Sway Characteristics in Women with Lower Extremity Arthritis before and after an Aquatic Exercise Intervention. Archives of Physical Medicine and Rehabilitation, 6, 780-785. 
http://dx.doi.org/10.1016/S0003-9993(00)90111-4</mixed-citation></ref><ref id="scirp.57283-ref153"><label>153</label><mixed-citation publication-type="other" xlink:type="simple">Green, J., McKenna, F., Redfern, E.J. and Chamberlain, M.A. (1993) Home Exercises Are as Effective as Outpatient Hydrotherapy for Osteoarthritis of the Hip. British Journal of Rheumatology, 32, 812-815. 
http://dx.doi.org/10.1093/rheumatology/32.9.812</mixed-citation></ref><ref id="scirp.57283-ref154"><label>154</label><mixed-citation publication-type="other" xlink:type="simple">Nguyen, M., Revel, M. and Dougados, M. (1997) Prolonged Effects of 3 Week Therapy in a Spa Resort on Lumbar Spine, Knee and Hip Osteoarthritis: Follow-Up after 6 Months. A Randomized Controlled Trial. British Journal of Rheumatology, 36, 77-81. http://dx.doi.org/10.1093/rheumatology/36.1.77</mixed-citation></ref><ref id="scirp.57283-ref155"><label>155</label><mixed-citation publication-type="journal" xlink:type="simple"><name name-style="western"><surname>Forestier</surname><given-names> R. </given-names></name>,<etal>et al</etal>. (<year>2000</year>)<article-title>Magnitude and Duration of the Effects of Two Spa Therapy Courses on Knee and Hip Osteoarthritis: An Open Prospective Study in 51 Consecutive Patients</article-title><source> Joint Bone and Spine</source><volume> 67</volume>,<fpage> 296</fpage>-<lpage>304</lpage>.<pub-id pub-id-type="doi"></pub-id></mixed-citation></ref><ref id="scirp.57283-ref156"><label>156</label><mixed-citation publication-type="other" xlink:type="simple">Callaghan, M.J., Oldham, J. and Hunt, J. (1995) An Evaluation of Exercise Regimes for Patients with Osteoarthritis of the Knee: A Single-Blind Randomized Controlled Trial. Clinical Rehabilitation, 9, 213-218. 
http://dx.doi.org/10.1177/026921559500900306</mixed-citation></ref><ref id="scirp.57283-ref157"><label>157</label><mixed-citation publication-type="other" xlink:type="simple">van Baar, M.E., Assendelft, W.J.J., Dekker, J., Oostendorp, R.A.B. and Bijlsma, J.W.J. (1999) Effectiveness of Exercise Therapy in Patients with Osteoarthritis of the Hip or Knee: A Systematic Review of Randomized Clinical Trials. Arthritis and Rheumatism, 42, 1361-1369. 
http://dx.doi.org/10.1002/1529-0131(199907)42:7&lt;1361::AID-ANR9&gt;3.0.CO;2-9</mixed-citation></ref><ref id="scirp.57283-ref158"><label>158</label><mixed-citation publication-type="other" xlink:type="simple">Odding, E., Valkenburg, H.A., Algra, D., Vandenouweland, F.A., Grobbee, D.E. and Hofman, A. (1998) Associations of Radiological Osteoarthritis of the Hip and Knee with Locomotor Disability in the Rotterdam Study. Annals of the Rheumatic Diseases, 57, 203-208. http://dx.doi.org/10.1136/ard.57.4.203</mixed-citation></ref><ref id="scirp.57283-ref159"><label>159</label><mixed-citation publication-type="other" xlink:type="simple">Moffett, J.A., Richardson, P.H., Frost, H. and Osborn, A. (1996) A Placebo Controlled Double Blind Trial to Evaluate the Effectiveness of Pulsed Short Wave Therapy for Osteoarthritic Hip and Knee Pain. Pain, 67, 121-127. 
http://dx.doi.org/10.1016/0304-3959(96)03100-4</mixed-citation></ref><ref id="scirp.57283-ref160"><label>160</label><mixed-citation publication-type="other" xlink:type="simple">Hamilton, D.E., Bywaters, E.G.L. and Please, N.W. (1959) A Controlled Trial of Various Forms of Physiotherapy in Arthritis. British Medical Journal, 2, 542-544. http://dx.doi.org/10.1136/bmj.1.5121.542</mixed-citation></ref><ref id="scirp.57283-ref161"><label>161</label><mixed-citation publication-type="other" xlink:type="simple">Barwick, P.A. and Swezey, R.L. (1982) Physical Therapies in Arthritis. Which to Choose, When to Use, How Not to Abuse. Postgraduate Medicine, 72, 223-233.</mixed-citation></ref></ref-list></back></article>