<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">ANP</journal-id><journal-title-group><journal-title>Advances in Nanoparticles</journal-title></journal-title-group><issn pub-type="epub">2169-0510</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/anp.2015.42004</article-id><article-id pub-id-type="publisher-id">ANP-55860</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Biomedical&amp;Life Sciences</subject><subject> Chemistry&amp;Materials Science</subject><subject> Engineering</subject></subj-group></article-categories><title-group><article-title>
 
 
  Exact Traveling Wave Solutions of Nano-Ionic Solitons and Nano-Ionic Current of MTs Using the exp(-φ (ξ ))-Expansion Method
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>mad</surname><given-names>H. M. Zahran</given-names></name><xref ref-type="aff" rid="aff1"><sub>1</sub></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Mathematical and Physical Engineering, College of Engineering, Shubra University of Benha,
Egypt</addr-line></aff><author-notes><corresp id="cor1">* E-mail:</corresp></author-notes><pub-date pub-type="epub"><day>02</day><month>04</month><year>2015</year></pub-date><volume>04</volume><issue>02</issue><fpage>25</fpage><lpage>36</lpage><history><date date-type="received"><day>3</day>	<month>January</month>	<year>2015</year></date><date date-type="rev-recd"><day>accepted</day>	<month>16</month>	<year>April</year>	</date><date date-type="accepted"><day>22</day>	<month>April</month>	<year>2015</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  In this work, the exp(-
  φ (ξ )) -expansion method is used for the first time to investigate the exact traveling wave solutions involving parameters of nonlinear evolution equations. When these parameters are taken to be special values, the solitary wave solutions are derived from the exact traveling wave solutions. The validity and reliability of the method are tested by its applications to Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs which play an important role in biology.
 
</p></abstract><kwd-group><kwd>The exp(-φ (ξ )) -Expansion Method</kwd><kwd> Nano-Solitons of Ionic Wave’s Propagation along Microtubules in Living Cells</kwd><kwd> Nano-Ionic Currents of MTs</kwd><kwd> Traveling Wave Solutions</kwd><kwd> Kink and Anti Kink Wave Solutions</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>1. Introduction</title><p>The nonlinear partial differential equations of mathematical physics are major subjects in physical science [<xref ref-type="bibr" rid="scirp.55860-ref1">1</xref>] . Exact solutions for these equations play an important role in many phenomena in physics such as fluid mechanics, hydrodynamics, Optics, Plasma physics and so on. Recently many new approaches for finding these solutions have been proposed, for example, tanh-sech method [<xref ref-type="bibr" rid="scirp.55860-ref2">2</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref4">4</xref>] , extended tanh-method [<xref ref-type="bibr" rid="scirp.55860-ref5">5</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref7">7</xref>] , sine-cosine method [<xref ref-type="bibr" rid="scirp.55860-ref8">8</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref10">10</xref>] , homogeneous balance method [<xref ref-type="bibr" rid="scirp.55860-ref11">11</xref>] [<xref ref-type="bibr" rid="scirp.55860-ref12">12</xref>] , F-expansion method [<xref ref-type="bibr" rid="scirp.55860-ref13">13</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref15">15</xref>] , exp-function method</p><p>[<xref ref-type="bibr" rid="scirp.55860-ref16">16</xref>] [<xref ref-type="bibr" rid="scirp.55860-ref17">17</xref>] , trigonometric function series method [<xref ref-type="bibr" rid="scirp.55860-ref18">18</xref>] , <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x8.png" xlink:type="simple"/></inline-formula>expansion method [<xref ref-type="bibr" rid="scirp.55860-ref19">19</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref22">22</xref>] , Jacobi elliptic function method [<xref ref-type="bibr" rid="scirp.55860-ref23">23</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref26">26</xref>] , The exp<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x9.png" xlink:type="simple"/></inline-formula>-expansion method [<xref ref-type="bibr" rid="scirp.55860-ref27">27</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref29">29</xref>] and so on.</p><p>The objective of this article is to investigate more applications than obtained in [<xref ref-type="bibr" rid="scirp.55860-ref27">27</xref>] -[<xref ref-type="bibr" rid="scirp.55860-ref29">29</xref>] to justify and dem-</p><p>onstrate the advantages of the exp<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x10.png" xlink:type="simple"/></inline-formula>-method. Here, we apply this method to Nano-solitons of ionic</p><p>waves’s propagation along microtubules in living cells and Nano-ionic currents of MTs.</p></sec><sec id="s2"><title>2. Description of Method</title><p>Consider the following nonlinear evolution equation</p><disp-formula id="scirp.55860-formula28"><label>(2.1)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x11.png"  xlink:type="simple"/></disp-formula><p>where F is a polynomial in <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x12.png" xlink:type="simple"/></inline-formula> and its partial derivatives in which the highest order derivatives and nonlinear terms are involved. In the following, we give the main steps of this method.</p><p>Step 1. We use the wave transformation</p><disp-formula id="scirp.55860-formula29"><label>(2.2)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x13.png"  xlink:type="simple"/></disp-formula><p>where c is a positive constant, to reduce Equation (2.1) to the following ODE:</p><disp-formula id="scirp.55860-formula30"><label>(2.3)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x14.png"  xlink:type="simple"/></disp-formula><p>where P is a polynomial in u(ξ) and its total derivatives.</p><p>Step 2. Suppose that the solution of ODE (2.3) can be expressed by a polynomial in <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x15.png" xlink:type="simple"/></inline-formula> as follow</p><disp-formula id="scirp.55860-formula31"><label>(2.4)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x16.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x17.png" xlink:type="simple"/></inline-formula> satisﬁes the ODE in the form</p><disp-formula id="scirp.55860-formula32"><label>(2.5)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x18.png"  xlink:type="simple"/></disp-formula><p>The solutions of ODE (2.5) are</p><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x19.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula33"><label>(2.6)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x20.png"  xlink:type="simple"/></disp-formula><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x21.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula34"><label>(2.7)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x22.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x23.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula35"><label>(2.8)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x24.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x25.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula36"><label>(2.9)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x26.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x27.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula37"><label>(2.10)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x28.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x29.png" xlink:type="simple"/></inline-formula> are constants to be determined later,</p><p>Step 3. Substitute Equation (2.4) along Equation (2.5) into Equation (2.3) and collecting all the terms of the same power <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x30.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x30.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x31.png" xlink:type="simple"/></inline-formula> and equating them to zero, we obtain a system of algebraic equations, which can be solved by Maple or Mathematica to get the values of.</p><p>Step 4. substituting these values and the solutions of Equation (2.5) into Equation (2.3) we obtain the exact solutions of Equation (2.1).</p></sec><sec id="s3"><title>3. Application</title><sec id="s3_1"><title>3.1. Example 1: Nano-Solitons of Ionic Wave’s Propagation along Microtubules in Living Cells [<xref ref-type="bibr" rid="scirp.55860-ref27">27</xref>]</title><p>We first consider an inviscid, incompressible and non-rotating flow of fluid of constant depth (h). We take the direction of flow as x-axis and z-axis positively upward the free surface in gravitational field. The free surface elevation above the undisturbed depth h is<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x32.png" xlink:type="simple"/></inline-formula>, so that the wave surface at height<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x32.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x33.png" xlink:type="simple"/></inline-formula>, while z = 0 is horizontal rigid bottom.</p><p>Let <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x34.png" xlink:type="simple"/></inline-formula> be the scalar velocity potential of the fluid lying between the bottom (z = 0) and free space<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x34.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x35.png" xlink:type="simple"/></inline-formula>, then we could write the Laplace and Euler equation with the boundary conditions at the surface and the bottom, respectively, as follows:</p><disp-formula id="scirp.55860-formula38"><label>(3.1)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x36.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula39"><label>(3.2)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x37.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula40"><label>(3.3)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x38.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula41"><label>(3.4)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x39.png"  xlink:type="simple"/></disp-formula><p>It is useful to introduce two following fundamental dimensionaless parameters:</p><disp-formula id="scirp.55860-formula42"><label>(3.5)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x40.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x41.png" xlink:type="simple"/></inline-formula> is the wave amplitude, and l is the characteristic length-like wavelength. Accordingly, we also take a complete set of new suitable non-dimensional variables:</p><disp-formula id="scirp.55860-formula43"><label>(3.6)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x42.png"  xlink:type="simple"/></disp-formula><p>where <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x43.png" xlink:type="simple"/></inline-formula> is the shallow-water wave speed, with g being gravitational acceleration. In term of (3.5) and (3.6) the initial system of Equations (3.1)-(3.4) now reads</p><disp-formula id="scirp.55860-formula44"><label>(3.7)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x44.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula45"><label>(3.8)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x45.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula46"><label>(3.9)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x46.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula47"><label>(3.10)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x47.png"  xlink:type="simple"/></disp-formula><p>Expanding <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x48.png" xlink:type="simple"/></inline-formula> in terms of δ</p><disp-formula id="scirp.55860-formula48"><label>(3.11)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x49.png"  xlink:type="simple"/></disp-formula><p>and using the dimensionless wave particles velocity in x-direction, by definition <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x50.png" xlink:type="simple"/></inline-formula> then substituting of (3.11) into (3.7)-(3.9), with retaining terms up to linear order of small parameters <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x50.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x51.png" xlink:type="simple"/></inline-formula> in (3.8), and second order in (3.9), we get</p><disp-formula id="scirp.55860-formula49"><label>(3.12)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x52.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula50"><label>(3.13)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x53.png"  xlink:type="simple"/></disp-formula><p>Making the differentiation of (3.12) with respect to<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x54.png" xlink:type="simple"/></inline-formula>, and rearranging (3.13), we get</p><disp-formula id="scirp.55860-formula51"><label>(3.14)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x55.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula52"><label>(3.15)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x56.png"  xlink:type="simple"/></disp-formula><p>Returning back to dimensional variables <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x57.png" xlink:type="simple"/></inline-formula> and<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x57.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x58.png" xlink:type="simple"/></inline-formula>, (3.14) now reads</p><disp-formula id="scirp.55860-formula53"><label>(3.16)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x59.png"  xlink:type="simple"/></disp-formula><p>We could define the new function <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x60.png" xlink:type="simple"/></inline-formula> unifying the velocity and displacement of water particles as follows:</p><disp-formula id="scirp.55860-formula54"><label>(3.17)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x61.png"  xlink:type="simple"/></disp-formula><p>implying that (3.16) becomes</p><disp-formula id="scirp.55860-formula55"><label>(3.18)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x62.png"  xlink:type="simple"/></disp-formula><p>We seek for traveling wave solutions with moving coordinate of the form <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x63.png" xlink:type="simple"/></inline-formula> and with wave speed<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x63.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x64.png" xlink:type="simple"/></inline-formula>, which reduces Equation (3.18) into ordinary nonlinear differential equation as follows:</p><disp-formula id="scirp.55860-formula56"><label>(3.19)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x65.png"  xlink:type="simple"/></disp-formula><p>Integrating Equation (3.19) once, and setting<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x66.png" xlink:type="simple"/></inline-formula>, we get</p><disp-formula id="scirp.55860-formula57"><label>(3.20)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x67.png"  xlink:type="simple"/></disp-formula><p>Balancing <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x68.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x69.png" xlink:type="simple"/></inline-formula> yields,<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x68.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x69.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x70.png" xlink:type="simple"/></inline-formula>. Therefore, we can write the solution of Equation (3.20) in the form</p><disp-formula id="scirp.55860-formula58"><label>(3.21)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x71.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula59"><label>(3.22)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x72.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula60"><label>(3.23)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x73.png"  xlink:type="simple"/></disp-formula><p>Substituting (3.21) along (3.23) into (3.20), setting the coefficients of<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x74.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x75.png" xlink:type="simple"/></inline-formula>,<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x76.png" xlink:type="simple"/></inline-formula> , <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x76.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x77.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x74.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x75.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x76.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x77.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x78.png" xlink:type="simple"/></inline-formula>to zero, we obtain the following underdetermined system of algebraic equations for (a<sub>0</sub>, a<sub>1</sub>, a<sub>2</sub>):</p><disp-formula id="scirp.55860-formula61"><label>(3.24)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x79.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula62"><label>(3.25)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x80.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula63"><label>(3.26)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x81.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula64"><label>(3.27)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x82.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula65"><label>(3.28)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x83.png"  xlink:type="simple"/></disp-formula><p>Solving the above system with the aid of Mathematica or Maple, we have the following solution:</p><disp-formula id="scirp.55860-formula66"><graphic  xlink:href="http://html.scirp.org/file/2-2610156x84.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula67"><graphic  xlink:href="http://html.scirp.org/file/2-2610156x85.png"  xlink:type="simple"/></disp-formula><p>Sothat the solution of Equation (3.20) will be in the form:</p><disp-formula id="scirp.55860-formula68"><label>(3.29)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x86.png"  xlink:type="simple"/></disp-formula><p>Consequently, the solution takes the forms:</p><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x87.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula69"><label>(3.30)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x88.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x89.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula70"><label>(3.31)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x90.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x91.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula71"><label>(3.32)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x92.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x93.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula72"><label>(3.33)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x94.png"  xlink:type="simple"/></disp-formula><p>When <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x95.png" xlink:type="simple"/></inline-formula></p><disp-formula id="scirp.55860-formula73"><label>(3.34)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x96.png"  xlink:type="simple"/></disp-formula></sec><sec id="s3_2"><title>3.2. Example 2. Nano-Ionic Currents of MTs</title><p>The Nano-ionic currents are elaborated in [<xref ref-type="bibr" rid="scirp.55860-ref27">27</xref>] take the form</p><disp-formula id="scirp.55860-formula74"><label>(3.35)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x97.png"  xlink:type="simple"/></disp-formula><p>where R = 0.34 &#215; 10<sup>9</sup> Ω is the resistance of the ER with length, l = 8 &#215; 19<sup>−9</sup> m, c<sub>0</sub> = 1.8&#215; 10<sup>−15</sup> F is the maximal capacitance of the ER, G<sub>0</sub> = 1.1 &#215; 10<sup>−13</sup> si is conductance of pertaining NPs and z = 5.56 &#215;10<sup>10</sup> Ω is the characteristic impedance of our system parameters δ and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x98.png" xlink:type="simple"/></inline-formula> describe nonlinearity of ER capacitor and conductance of NPs in ER, respectively. In order to solve Equation (3.35) we use the travelling wave transformations<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x99.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x99.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x100.png" xlink:type="simple"/></inline-formula>with<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x98.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x99.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x100.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x101.png" xlink:type="simple"/></inline-formula>, to reduce Equation (3.35) to the following nonlinear ordinary differential equation:</p><disp-formula id="scirp.55860-formula75"><label>(3.36)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x102.png"  xlink:type="simple"/></disp-formula><p>Which can be written in the form</p><disp-formula id="scirp.55860-formula76"><label>(3.37)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x103.png"  xlink:type="simple"/></disp-formula><p>where</p><disp-formula id="scirp.55860-formula77"><label>(3.38)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x104.png"  xlink:type="simple"/></disp-formula><p>Thus Equation (3.37) take the form</p><disp-formula id="scirp.55860-formula78"><label>(3.39)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x105.png"  xlink:type="simple"/></disp-formula><p>Balancing <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x106.png" xlink:type="simple"/></inline-formula> and <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x106.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x107.png" xlink:type="simple"/></inline-formula> yields,<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x106.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x107.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x108.png" xlink:type="simple"/></inline-formula>. Consequently, we get</p><disp-formula id="scirp.55860-formula79"><label>(3.40)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x109.png"  xlink:type="simple"/></disp-formula><p>Where a<sub>0</sub>, a<sub>1</sub>, a<sub>2</sub> are arbitrary constants such that a<sub>2</sub> ≠ 0. From Equation (3.40), it is easy to see that</p><disp-formula id="scirp.55860-formula80"><label>(3.41)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x110.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula81"><label>(3.42)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x111.png"  xlink:type="simple"/></disp-formula><p>Substituting Equations (3.40)-(3.42) into Equation (3.39) and equating the coefficients of <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula> <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x113.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x114.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x114.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x115.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x114.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x116.png" xlink:type="simple"/></inline-formula>, <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x112.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x113.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x114.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x115.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x116.png" xlink:type="simple"/></inline-formula><inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x117.png" xlink:type="simple"/></inline-formula>to zero, we obtain</p><disp-formula id="scirp.55860-formula82"><label>(3.43)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x118.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula83"><label>(3.44)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x119.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula84"><label>(3.45)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x120.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula85"><label>(3.46)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x121.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula86"><label>(3.47)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x122.png"  xlink:type="simple"/></disp-formula><disp-formula id="scirp.55860-formula87"><label>(3.48)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x123.png"  xlink:type="simple"/></disp-formula><p>Solving above system with the aid of Mathematica or Maple, we have the following solution:</p><disp-formula id="scirp.55860-formula88"><graphic  xlink:href="http://html.scirp.org/file/2-2610156x124.png"  xlink:type="simple"/></disp-formula><p>a<sub>1</sub> = a<sub>1</sub>, a<sub>2</sub> = a<sub>2</sub>.</p><p>So that the solution of Equation (3.39) will be in the form:</p><disp-formula id="scirp.55860-formula89"><label>(3.49)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x125.png"  xlink:type="simple"/></disp-formula><p>Consequently, the solution take the forms:</p><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x126.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula90"><label>(3.50)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x127.png"  xlink:type="simple"/></disp-formula><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x128.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula91"><label>(3.51)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x129.png"  xlink:type="simple"/></disp-formula><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x130.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula92"><label>(3.52)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x131.png"  xlink:type="simple"/></disp-formula><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x132.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula93"><label>(3.53)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x133.png"  xlink:type="simple"/></disp-formula><p>When<inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x134.png" xlink:type="simple"/></inline-formula>,</p><disp-formula id="scirp.55860-formula94"><label>(3.54)</label><graphic position="anchor" xlink:href="http://html.scirp.org/file/2-2610156x135.png"  xlink:type="simple"/></disp-formula></sec></sec><sec id="s4"><title>4. Results and Conclusion</title><p>In nanobiosciences the transmission line models for ionic waves propagating along microtubules in living cells play an important role in cellular signaling where ionic wave’s propagating along microtubules in living cells shaped as nanotubes that are essential for cell motility, cell division , intracellular trafficking and information processing within neuronal processes. ionic waves propagating along microtubules in living cells have been also implicated in higher neuronal functions, including memory and the emergence of consciousness and we presented an inviscid, incompressible and non-rotating flow of fluid of constant depth (h). The <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x136.png" xlink:type="simple"/></inline-formula>-ex- pansion method has been successfully used to find the exact traveling wave solutions of some nonlinear evolution equations and <xref ref-type="fig" rid="fig1">Figure 1</xref> and <xref ref-type="fig" rid="fig2">Figure 2</xref> show the solitary wave solution of both equations. As an application,</p><fig-group id="fig1"><label><xref ref-type="fig" rid="fig1">Figure 1</xref></label><caption><title> Solution of Equations (3.30)-(3.34). (a) Equation (3.30); (b) Equation (3.31); (c) Equation (3.32); (d) Equation (3.33); (e) Equation (3.34).</title></caption><fig id ="fig1_1"><label> (b)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x137.png"/></fig><fig id ="fig1_2"><label>(c)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x138.png"/></fig><fig id ="fig1_3"><label> (d)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x139.png"/></fig></fig-group><fig-group id="fig2"><label><xref ref-type="fig" rid="fig2">Figure 2</xref></label><caption><title> Solutiou of Equations (3.50)-(3.54). (a) Equation (3.50); (b) Equation (3.51); (c) Equation (3.52); (d) Equation (3.53); (e) Equation (3.54)</title></caption><fig id ="fig2_1"><label> (b)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x140.png"/></fig><fig id ="fig2_2"><label>(c)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x141.png"/></fig><fig id ="fig2_3"><label> (d)</label><graphic mimetype="image"   position="float"  xlink:type="simple"  xlink:href="http://html.scirp.org/file/2-2610156x142.png"/></fig></fig-group><p>the traveling wave solutions for As an application, the traveling wave solutions for Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs, which have been constructed using the <inline-formula><inline-graphic xlink:href="http://html.scirp.org/file/2-2610156x143.png" xlink:type="simple"/></inline-formula>-expansion method. Let us compare our results obtained in the present article with the well-known results obtained by other authors using different methods as follows: Our results of Nano-ionic solitons wave’s propagation along microtubules in living cells and Nano-ionic currents of MTs [<xref ref-type="bibr" rid="scirp.55860-ref27">27</xref>] . It can be concluded that this method is reliable and propose a variety of exact solutions NPDEs. The performance of this method is effective and can be applied to many other nonlinear evolution equations.</p></sec></body><back><ref-list><title>References</title><ref id="scirp.55860-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Maliet, W. (1992) Solitary Wave Solutions of Nonlinear Wave Equation. American Journal of Physics, 60, 650-654. http://dx.doi.org/10.1119/1.17120</mixed-citation></ref><ref id="scirp.55860-ref2"><label>2</label><mixed-citation publication-type="other" xlink:type="simple">Maliet, W. and Hereman, W. 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