The case studies are about atypical bilateral, postoperative Cystoid Macular Edema (CME) in two patients who underwent bilateral uncomplicated pha- coemulsification surgery with a trifocal Intraocular Lens (IOL). In postoperative follow-up, both the cases presented with complaints of bilateral blurring of vision. Irvine-Gass syndrome has been diagnosed after evaluation of the retina by fundoscopy and OCT macula. Posterior subtenon steroid injection has been prescribed and given. Regular OCT examinations indicated substantial ede- ma improvement. Subsequent improvement in visual acuity was also noted in both cases. Cystoid macular edema can happen in any case irrespective of the quality of IOL. The visual outcome is satisfactorily responsive towards steroid medication.
A cataract is a common ocular phenomenon worldwide for older people. Phacoemulsification is the most modernized technique of cataract surgery and is commonly performed in ophthalmic practice. Though it has reduced the chance of surgical injury to the eye, unlike any other surgical procedures, it may produce complications. The pseudophakic cystoid macular edema is a severe and rare complication of uncomplicated cataract surgery that can cause transient or even permanent vision loss [
The purpose of this article is to notify the possibility of Irvine-Gass syndrome following phacoemulsification surgery, even if a premium trifocal lens is used and the procedure was uneventful.
A 51 years old male, the non-diabetic, non-hypertensive patient, underwent uncomplicated and uneventful phacoemulsification surgery in both eyes, one day apart due to bilateral age-related cataract in November 2020. Trifocal IOL (Panoptics IOL by Alcon) was implanted in both eyes. Preoperative examination revealed BCVA in both eyes (BE) was 6/18 in Snellen’s chart and 0.48 in the LogMAR chart. IOL Master measured the axial length, anterior chamber depth and lens thickness of the right eye about 23.34 mm, 3.40 mm, 4.28 mm and the left eye approximately 23.26 mm, 3.31 mm, 4.38 mm, respectively. Swept-source OCT checked preoperative retinal morphology. Macular thickness was 246 µm in the right eye and 245 µm in the left eye. He had no significant ocular history of uveitis or retinal disease but gave the history of having hyperthyroidism as medical history. The patient underwent uneventful phacoemulsification surgery with posterior chamber Trifocal Intraocular lens (Panoptics) implantation within the bag under topical anaesthesia in both eyes. The IOL power was 22.0 D in RE and 22.50 in L.E.. The surgery was done by an experienced surgeon. The immediate post-operative evaluation was favourable. BCVA in the first Post-Operative Day (POD) was 6/6 partial in Snellen’s chart and 0.00 in the LogMAR chart in both eyes. The anterior segment and the anterior chamber were clear; there was no sign of inflammation or abnormality seen in the vitreous. The patient was discharged from the hospital. He came for postoperative follow-up after one month with complaints of gradual blurring of vision in both eyes.
In both eyes, the BCVA drop down to 6/18 in Snellen’s chart and 0.48 in the LogMAR chart. Central Corneal Thickness (CCT) was 560 µm in the right eye and 570 µm in the left eye. Intra-Ocular Pressure (IOP) was 13 mm Hg and 11 mm Hg in the right and left eye, respectively. Investigations had done to find out the aetiology behind this post-surgical reduced vision. RFNL thickness and OCT macula had done for both eyes. RFNL thickness reports didn’t reveal any abnormality, but a remarkable elevation in macular thickness is shown in
The case was diagnosed as bilateral cystoid macular edema (CME)/Irvine-Gass syndrome. The patient was prescribed NSAID, artificial tear, and antibiotic eye drop and was referred to the retina specialist for posterior subtenon administration of injectable steroid. The patient was counselled adequately before the initiation of steroid injection and about its possible side effects. Injection Triamcinolone Acetonide has been given in both eyes on two consecutive days. Triamcinolone acetonide 1 ml, 40 mg/ml, administered at the posterior sub tenon space with a 26 G needle bevel down following the curve of the globe superotemporally. We did not notice any side effects of the subtenon injections. Repeat OCT macula was done to evaluate the effect of steroids on macula after one week. The repeat OCT showed a significant reduction in macular thickness, 292 µm in the right eye and 307 µm in the left eye (
with BCVA 6/6p, 0.00 in the right eye, and 6/6, 0.00 in the left eye by Snellen’s and LogMAR charts. The injectable steroid has been proven to have a good response after one week. The patient was maintaining BCVA of 6/6, 0.00 by Snellen’s and LogMAR charts in both eyes on the subsequent follow up of 1 month and six months.
A 56 years old male patient underwent uneventful phacoemulsification surgery within bag Trifocal IOL (Panoptics) implantation. He came for follow-up on 30 December 2020 with the chief complaints of the dimness of vision in both eyes for one week. His I.O.P. was 20 mm Hg in the right eye and 17 mm Hg in the left eye. Unaided visual acuity was 6/18 (Snellen chart), 0.48 (in Log M.A.R. chart) in both eyes. The patient was hypertensive and non-diabetic. On funduscopy, the macula was dull in both eyes, which were suggestive of suspected macular edema. OCT macula was done on that day to confirm the diagnosis. On OCT, the central macular thickness was 534 µm in the right eye and 542 in the left eye shown in
We diagnosed Irvine Gass Syndrom or Pseudophakic Cystoid Macular Edema based on the significant intraretinal and subretinal fluid deposition detected on the macular imaging. The patient was advised with a posterior subtenon steroid injection. The patient and the attendant were counselled adequately about the treatment procedure’s process, prognosis, and possible side effects. Posterior subtenon injection Triamcinolone Acetonide has been given in both eyes in two consecutive days. The patient was advised to return in three weeks for a follow-up OCT to examine the effect of the steroid on the macula. On follow-up, after three weeks (23 January 2021), the patient’s visual acuity improved to 6/6 in the Snellen chart and 0.00 in the LogMAR chart in both eyes. IOP were 12 and 16 mm Hg in the right and left eyes, respectively. On fundus examination, the discs were normal, and there was no sign of macular edema in both right and left eyes. To date, the patient is maintaining visual acuity of 6/6.
Repeat OCT macula on that day (23 January 2021) showed reduced central macular thickness. The macular thickness in OCT was 237 µm in the right eye and 236 µm in the left eye, shown in
In both cases, Irvine-Gass syndrome occurred, irrespective of the use of a premium IOL (Trifocal Panoptics IOL), which was managed by administering posterior sub tenon injections.
CME is a primary cause of reduced vision after cataract surgery. Many risk factors like prolonged surgery, use of topical prostaglandin analogue, diabetes etc., can cause Irvine-Gas syndrome. The pathophysiological mechanism responsible for post-operative CME is also not explained yet. Irvine proposed that early changes occur due to direct macular traction from the prolapsed vitreous [
CME can cause unexpected compromised postoperative loss of vision even after uncomplicated cataract surgery. The differential diagnosis can take into consideration to confirm the cause of diminished vision after phacoemulsification. TASS (Toxic Anterior Segment Syndrome) is a rare, acute, and severe intraocular inflammation that usually takes place within 12 - 48 hrs. Our patient had no increased intraocular pressure, diffuse corneal edema, hypopyon, or photophobia. So TASS can be excluded. Hypotonus maculopathy is another complication that may cause postoperative dimness of vision. This possibility can also be excluded as the patient’s intraocular pressure was within the normal limit. Retinal vein occlusion and vitreomacular traction could be potential causes of postoperative visual loss [
In mild cases, postoperative CME resolves spontaneously and requires no treatment. Some eyes resist common medical treatment strategies, including systemic or topical non-steroidal anti-inflammatory drugs [
In our case studies, both patients developed CME after uneventful phacoemulsification surgery. Postoperative OCT showed a significant change in macular thickness. Posterior Subtenon Injection (PST) has been given with a 26 G needle bevel down along the curvature of the globe supero temporally. PST injection showed remarkable vision improvement. The results have been documented by post-procedure OCT macula and manifest visual refraction, which showed significant improvement with decreased edema and increased visual acuity.
Irvine-Gass syndrome can happen following uncomplicated phacoemulsification surgery, irrespective of using a premium Intraocular Lens. To date, to the best of our knowledge, back to back cases of Irvine-Gass syndrome after uneventful phacoemulsification surgery with Trifocal Panoptics IOL were not reported. As a result, we have decided to report these two unusual incidents.
We are thankful to the patients’ family for their kind consideration regarding the photographs for publication.
The authors declare no conflict of interest regarding the publication of this paper.
Anwar, I., Rahman, S., Akhter, S., Hassan, S.N., Hossain, M.S., Rahman, S. and Rahman, A. (2022) Postoperative Acute Bilateral Irvine-Gass Syndrome following Uncomplicated Phacoemulsification Surgery with Trifocal IOL—Two Case Reports. Open Journal of Ophthalmology, 12, 34-43. https://doi.org/10.4236/ojoph.2022.121004