<?xml version="1.0" encoding="UTF-8"?><!DOCTYPE article  PUBLIC "-//NLM//DTD Journal Publishing DTD v3.0 20080202//EN" "http://dtd.nlm.nih.gov/publishing/3.0/journalpublishing3.dtd"><article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" dtd-version="3.0" xml:lang="en" article-type="research article"><front><journal-meta><journal-id journal-id-type="publisher-id">JDM</journal-id><journal-title-group><journal-title>Journal of Diabetes Mellitus</journal-title></journal-title-group><issn pub-type="epub">2160-5831</issn><publisher><publisher-name>Scientific Research Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.4236/jdm.2021.115027</article-id><article-id pub-id-type="publisher-id">JDM-113230</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine&amp;Healthcare</subject></subj-group></article-categories><title-group><article-title>
 
 
  Evaluation in Diagnosis and Management of Diabetic Neuropathy
 
</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Wendy</surname><given-names>Waldman Zadeh</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Pichit</surname><given-names>Thanupakorn</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib></contrib-group><aff id="aff2"><addr-line>University of Iowa Hospitals &amp;amp; Clinics, Iowa City, USA</addr-line></aff><aff id="aff1"><addr-line>Broadlawns Medical Center, Des Moines, USA</addr-line></aff><pub-date pub-type="epub"><day>15</day><month>11</month><year>2021</year></pub-date><volume>11</volume><issue>05</issue><fpage>348</fpage><lpage>353</lpage><history><date date-type="received"><day>22,</day>	<month>September</month>	<year>2021</year></date><date date-type="rev-recd"><day>15,</day>	<month>November</month>	<year>2021</year>	</date><date date-type="accepted"><day>18,</day>	<month>November</month>	<year>2021</year></date></history><permissions><copyright-statement>&#169; Copyright  2014 by authors and Scientific Research Publishing Inc. </copyright-statement><copyright-year>2014</copyright-year><license><license-p>This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/</license-p></license></permissions><abstract><p>
 
 
  The 100-year anniversary of insulin is explored by focusing on diabetic neuropathy. Neuropathy is so common to diabetes, it is well described even in the earliest accounts of diabetes. This article reviews the most common neuropathy syndromes, and the consensus of effective treatment for neuropathic pain. Pharmacological advances in neuropathy are still largely focused on pain control, not neuropathy intervention. The article reviews the established and lesser tested therapies used for pain control. It also reviews the pathophysiology of the disease state, including the many factors and steps that culminate to produce neuropathy and its different iterations. In the future, new ways to treat diabetic neuropathy may be geared toward treating specific pathophysiological step-points on the way to nerve damage. In the future, prevention and a deeper look at the impact of socioeconomic status as a predictor of diabetes will hopefully encompass a bigger part of pre-diabetic care.
 
</p></abstract><kwd-group><kwd>Diabetic Neuropathy</kwd><kwd> Glycemic Control</kwd><kwd> Glycation End Products</kwd><kwd> Neuropathy Pain Medications</kwd><kwd> Preventive Medicine</kwd><kwd> Socioeconomic Status</kwd></kwd-group></article-meta></front><body><sec id="s1"><title>Conflicts of Interest</title><p>The authors declare no conflicts of interest regarding the publication of this paper.</p></sec><sec id="s2"><title>Cite this paper</title><p>Zadeh, W.W. and Thanupakorn, P. (2021) Evaluation in Diagnosis and Management of Diabetic Neuropathy. Journal of Diabetes Mellitus, 11, 348-353. https://doi.org/10.4236/jdm.2021.115027</p></sec></body><back><ref-list><title>References</title><ref id="scirp.113230-ref1"><label>1</label><mixed-citation publication-type="other" xlink:type="simple">Skljarevski, V. and Lledo, A. (2006) Diabetic Neuropathies. 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